Childhood neglect is associated with reduced corpus callosum area

Teicher, Martin H.; Dumont, Nathalie L.; Ito, Yutaka; Vaituzis, Catherine; Giedd, Jay N.; Andersen, Susan

doi:10.1016/j.biopsych.2004.03.016

Cited by 408 publications

(312 citation statements)

References 22 publications

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“…However, another larger MRI study did not find smaller corpus callosum volumes in ADHD children (Castellanos et al, 1996), possibly because this study did not control for position of the brain (Giedd et al, 2001). Another recent study found that childhood abuse was associated with a reduction in area on MRI in the anterior midbody of the corpus callosum (Teicher et al, 2004). Thus, factors that could predispose individuals to substance abuse could also be responsible for changes in corpus callosal white matter.…”

Section: Discussionmentioning

confidence: 76%

Reduced Anterior Corpus Callosum White Matter Integrity is Related to Increased Impulsivity and Reduced Discriminability in Cocaine-Dependent Subjects: Diffusion Tensor Imaging

Moeller

Hasan

Steinberg

et al. 2004

Neuropsychopharmacol

244

202

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Brain imaging studies find evidence of prefrontal cortical dysfunction in cocaine-dependent subjects. Similarly, cocaine-dependent subjects have problems with behaviors related to executive function and impulsivity. Since prefrontal cortical axonal tracts cross between hemispheres in the corpus callosum, it is possible that white matter integrity in the corpus callosum could also be diminished in cocainedependent subjects. The purpose of this study was to compare corpus callosum white matter integrity as measured by the fractional anisotropy (FA) on diffusion tensor imaging (DTI) between 18 cocaine-dependent subjects and 18 healthy controls. The Barratt Impulsiveness Scale (BIS-11) and a continuous performance test: the Immediate and Delayed Memory Task (IMT/DMT) were also collected. Results of the DTI showed significantly reduced FA in the genu and rostral body of the anterior corpus callosum in cocainedependent subjects compared to controls. Cocaine-dependent subjects also had significantly higher BIS-11 scores, greater impulsive (commission) errors, and reduced ability to discriminate target from catch stimuli (discriminability) on the IMT/DMT. Within cocaine dependent subjects there was a significant negative correlation between FA in the anterior corpus callosum and behavioral laboratory measured impulsivity, and there was a positive correlation between FA and discriminability. The finding that reduced integrity of anterior corpus callosum white matter in cocaine users is related to impaired impulse control and reduced ability to discriminate between target and catch stimuli is consistent with prior theories regarding frontal cortical involvement in impaired inhibitory control in cocainedependent subjects.

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Section: Discussionmentioning

confidence: 76%

Reduced Anterior Corpus Callosum White Matter Integrity is Related to Increased Impulsivity and Reduced Discriminability in Cocaine-Dependent Subjects: Diffusion Tensor Imaging

Moeller

Hasan

Steinberg

et al. 2004

Neuropsychopharmacol

244

202

View full text Add to dashboard Cite

show abstract

“…On the other hand, previous studies of changes in the corpus callosum in victims of CA have reported that the reduction in this brain structure occurs in the middle and posterior regions [38], and not in the rostral portion (genu and rostrum) that connect the right and left frontal lobes. While this could explain why we did not find a lower inter-frontal correlation in the PTSD group, it does not explain the higher interhemispheric correlation.…”

Section: Discussionmentioning

confidence: 77%

“…The hypothesis of lower inter-frontal correlation in PTSD individuals was based on two previous findings: the report of reduced frontal (anterior) interhemispheric coherence in adolescents with childhood maltreatment [13], and reports of volume decreases in the corpus callosum in survivors of CA with PTSD [6] [37] and hospitalized children with a history of abuse or neglect [38] [39]. The reduced size of the corpus callosum is associated with a diminished communication between the hemispheres [4] [40].…”

Section: Discussionmentioning

confidence: 99%

EEG Correlations during WCST Performance in Female Adolescents with Sexual Abuse-Related Post-Traumatic Stress Disorder

Martínez¹,

Sanz-Martín²,

Guevara³

et al. 2015

JBBS

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Child sexual abuse (CSA) survivors can present post-traumatic stress disorder (PTSD) and alterations in EEG activity and cognition. The aim of this study was to evaluate EEG correlations in female adolescents with CSA-related PTSD during performance of the Wisconsin Card-Sorting Test (WSCT). Inter-and intrahemispheric EEG correlations (INTERr and INTRAr) of those subjects were calculated at rest and during performance of WCST. On this task, the PTSD group obtained higher scores than the control group for the number of correct responses and failure to maintain set. In the between-groups comparisons, the PTSD group presented a higher INTERr between frontal areas in the gamma and slow bands, as well as a higher correlation in the delta band at Fp1-F3; however, this group presented a lower INTRAr between Fp1-P3 and Fp2-P4 in the theta and alpha1 bands. In the comparison between conditions, the PTSD group presented an increased correlation during execution of the WCST, mainly in the gamma band, while the control group showed a decrease of INTRAr in the slow bands. Results are discussed with respect to the influence of CSArelated PTSD on the development of cognition and functional connectivity in the brain.

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“…Consequently, traumatic early-life experiences have been shown to exacerbate transformation processes of cerebral structures linked to emotional regulation (van Harmelen et al, 2010;Teicher et al, 2004). Small hippocampal volumes have been repeatedly detected in subjects affected by childhood maltreatment (Dannlowski et al, 2012;Teicher and Samson, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

Opel

Redlich

Zwanzger

et al. 2014

Neuropsychopharmacol

169

104

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Reduced hippocampal volumes are probably the most frequently reported structural neuroimaging finding associated with major depressive disorder (MDD). However, it remains unclear whether altered hippocampal structure represents a risk factor for or a consequence of MDD. Reduced hippocampal volumes were consistently reported in subjects affected by childhood maltreatment. As the prevalence of childhood maltreatment is highly elevated in MDD populations, previous morphometric findings regarding hippocampal atrophy in MDD therefore might have been confounded by maltreatment experiences. The aim of this study was to differentiate the impact of childhood maltreatment from the influence of MDD diagnosis on hippocampal morphometry. Depressed patients (85) as well as 85 age-and sex-matched healthy controls underwent structural MRI. The Childhood Trauma Questionnaire was administered to estimate experiences of childhood maltreatment. Hippocampal volume and surface structure was examined by the use of two independent methods, automated segmentation (FSL-FIRST) and voxel-based morphometry (VBM8). In line with existing studies, MDD patients showed reduced hippocampal volumes, and childhood maltreatment was consistently associated with hippocampal volume loss in both, patients and healthy controls. However, no analysis revealed significant morphological differences between patients and controls if maltreatment experience was regressed out. Our results suggest that hippocampal alterations in MDD patients may at least partly be traced back to higher occurrence of early-life adverse experiences. Regarding the strong morphometric impact of childhood maltreatment and its distinctly elevated prevalence in MDD populations, this study provides an alternative explanation for frequently observed limbic structural abnormalities in depressed patients.

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Childhood neglect is associated with reduced corpus callosum area

Cited by 408 publications

References 22 publications

Reduced Anterior Corpus Callosum White Matter Integrity is Related to Increased Impulsivity and Reduced Discriminability in Cocaine-Dependent Subjects: Diffusion Tensor Imaging

Reduced Anterior Corpus Callosum White Matter Integrity is Related to Increased Impulsivity and Reduced Discriminability in Cocaine-Dependent Subjects: Diffusion Tensor Imaging

EEG Correlations during WCST Performance in Female Adolescents with Sexual Abuse-Related Post-Traumatic Stress Disorder

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

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