Childhood Myocarditis Associated With Chlamydia trachomatis Infection

Jt, Grayston; Mordhorst, Carl H.; Sp, Wang

doi:10.1001/jama.1981.03320240031020

Cited by 33 publications

(3 citation statements)

References 15 publications

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“…Besides the respiratory infection caused by this organism, interest has been focussed on a possible association with cardiac disease, including peri-, myo-and endocarditis [8][9][10]. Further research has suggested an association between C. Foundation) antigen were measured in a simplified microimmunofluorescence test as previously described [11].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of antibodies toChlamydia pneumoniae; determinants of IgG and IgA seropositivity among Jerusalem residents

et al. 1995

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SUMMARYThe prevalence of antibodies to Chlamydia pneumoniae was examined in a stratified random sample of 581 Jerusalem adult residents between August 1987 and March 1989. IgG and IgA titres were measured by microimmunofluorescence, and associations with smoking and socio-demographic variables were assessed. IgG antibodies were found in 84 5 % (95 % confidence interval (CI): 80A4-87-9) of men and 68-7 % (95% CI: 611-675-0) of women (P < 00001 for sex difference), indicating a very high rate of exposure in this population. IgA antibodies, postulated to represent persistent infection, were present in 45-1% (95% CI: 4041-50-2) of men and 23% (95% CI: 17-4-29-7) of women (P < 0.0001 for sex difference). Factors associated with IgG seropositivity included family size, education and social class. On the other hand, age (in men) and smoking were associated with IgA seropositivity. These findings support the hypothesis that low socioeconomic status and household crowding may be predictive of exposure to or infection with this organism (IgG seropositivity), whereas they do not explain persistence of the infection putatively expressed as IgA seropositivity.

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Section: Introductionmentioning

confidence: 99%

High prevalence of antibodies toChlamydia pneumoniae; determinants of IgG and IgA seropositivity among Jerusalem residents

et al. 1995

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“…Conjunctivitis, pneumonia, myocarditis, otitis media and other diseases may develop in neonates born to mothers infected with chlamydia [4,18]. The results of this study revealed that the prevalence of C. trachomatis is 11.3%.…”

Section: Discussionmentioning

confidence: 70%

Rapid Diagnosis of Chlamydial Infection in Young Women at Reproductive Age

Mammani¹,

Goreal²,

Omer³

et al. 2012

UCMS

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Aim: To determine the seroprevalence of Chlamydia trachomatis in a group of randomly selected pregnant women, using the ELISA IgG and IgM assays. The study included 88 married women whose age range was 19-38 years. This study was conducted in the Microbiology lab at Azadi Teaching Hospital from February 2009 to Dec 2009 in Duhok city. Two endocervical swabs were taken from each woman, the first to be examined as wet preparation stain to find bacteria, RBCs, epithelial cells, monilia, Trichomonas vaginalis, the second swab was used to examine for the presence of Chlamydia trachomatis antibodies by ELISA anti Chlamydia specific IgM, and anti Chlamydia specific IgG. The wet preparation examination of the swabs revealed Trichomonas vaginalis in 4 patients. Gram's stain revealed the presence of Gram positive Streptococci in 10 patients, Gram negative bacilli in 6 patients, and no bacteria was found in 45 patients. ELISA test to detect anti Chlamydia Antibodies (IgM), all the 88 examined women were negative. ELISA test to measure the anti Chlamydial antibodies (IgG) detect chronic infections and the results showed ten positive cases, 10/88 (11.3%). The age group of eight out of ten IgG positive cases is between 21-30 years old, for the remaining two cases is between 31-40 years old. Five of the IgG positive cases had history of ectopic pregnancies; another two had history of acute conjunctivitis in their newborn babies, while the remaining three had chronic infection and discharge. The results of this study revealed that the commercially available rapid test is of no value in detection of Chlamydia in endocervical swabs. The trend should be toward the substitution of this test by the direct immunoflourescence test. The nucleic acid amplification test which is highly sensitive should be used in future studies to detect the prevalence of Chlamydia infection.

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“…A decision maker who considers pyloric stenosis to be more serious than its relative weight in our model, in general or in specific circumstances (for instance, a clinician or parent deciding about prophylaxis for an infant with higher-than-average anesthetic risk), would be less inclined to give erythromycin prophylaxis than the model suggests. On the other hand, if future studies confirm long-term consequences of neonatal chlamydia exposure, as have been suggested by studies [36][37][38] showing that infants with C trachomatis pneumonia may have long-term chronic pulmonary effects and by reports [39][40][41] of infants with neonatal chlamydia infection and myocarditis or sudden infant death syndrome, then the relative value of preventing C trachomatis infection would increase in comparison with avoiding pyloric stenosis.…”

Section: Commentmentioning

confidence: 80%