Childhood meningiomas associated with meningioangiomatosis: report of five cases and literature review

Kim, N. R.; Choe, Gheeyoung; Shin, Seoung-Ryeol; Wang, K.-C.; Cho, B.-K.; Choi, Kwan-Woo; G., Je

doi:10.1046/j.1365-2990.2002.00365.x

Cited by 58 publications

(57 citation statements)

References 20 publications

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“…Microscopically, nodules resembling meningioma was representative of our case. This finding may support previous reports describing concomitance of meningioma adjacent to MA [3, 4]. …”

Section: Discussionsupporting

confidence: 93%

Cystic Meningioangiomatosis

et al. 2006

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A case of cerebral meningioangiomatosis with rare cyst formation is reported. A 14-year-old boy without any stigmata of neurofibromatosis type 2 presented intractable complex partial and generalized seizures since the age of 12 years. Neuroradiological studies showed an abnormal cystic mass with calcification in the left frontal lobe of the cerebrum. The tumor was located in the leptomeninges and cerebral cortex. The patient underwent surgical treatment because medical treatment with phenytoin and sodium valproate was not sufficient to control the seizures. An intraoperative electrocorticogram revealed that epileptic foci were recorded from the cortex, which was adjacent to the lesion. Histopathology showed specific features of meningioangiomatosis with meningioma-like nodules. The patient did not have any seizures with anticonvulsants after surgery. It is important to distinguish meningioangiomatosis from other possible cortical lesions and epileptic foci should be carefully considered before resection, because it is a benign and surgically manageable cause of seizures.

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“…Microscopically, nodules resembling meningioma was representative of our case. This finding may support previous reports describing concomitance of meningioma adjacent to MA [3, 4]. …”

Section: Discussionsupporting

confidence: 93%

Cystic Meningioangiomatosis

et al. 2006

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“…The commonest finding on computerised tomography (CT) scan is usually iso-to slightly hyperintense that show variable amount of calcification with little or no contrast enhancement but low-density lesions and normal CT images have also been reported 11,22,27 . MRI are confined to the cortex and consist of iso or hypointensity on T1-weighter images and heterogeneous cortical mass surrounded by an area of increased intensity on T2-weighter images, probably due to oedema or gliosis 6,18,25 .…”

Section: Imagingmentioning

confidence: 99%

Meningioangiomatosis: clinical-radiological features and surgical outcome

et al. 2010

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SummaryMeningioangiomatosis (MA) is a rare, benign neoplastic disorder involving the cortex and leptomeninges, the sporadic form, commonly presents as refractory localization-related epilepsy, but could be asymptomatic especially in older patients. The imaging features may be entirely non-specific. Magnetic Resonance Imaging (MRI) erroneously suggests meningioma, lowgrade tumour or vascular malformations.The pathological findings are characterised by proliferation of meningothelial cells and leptomeningeal vessels and calcifications within the mass. Macroscopically there is dense thickening in the underlying cortex, often in a sharply defined area.In this article we report 3 cases of MA, neither of whom had a familiary history or stigmata of Neurofibromatosis (NF). We discuss and place particular emphasis on the clinical presentation and diagnosis imaging, as well as on the outcome. We also review the literature concerning about the aetiology, pathology findings and imaging features of MA.KEY WORDS: Brain tumor. Histopathology. Meningioangiomatosis. Magnetic resonance imaging. Seizure. Meningioangiomatosis: características clínico-radioló-gicas y resultados quirúrgicos ResumenLa meningioangiomatosis (MA) es un proceso neoplásico benigno raro, que envuelve el córtex y leptomeninges, en su forma esporádica comúnmente se presenta con epilepsia refractaria, en relación a su localización, pero puede ser asintomática, especialmente en adultos mayores. Las características de imagen pueden ser totalmente inespecíficas. Las imágenes de resonancia magnética erróneamente sugieren la presencia de un meningioma, tumores de bajo grado, o malformaciones vasculares.Los hallazgos patológicos se caracterizan por la proliferación de células meningoteliales, vasos leptomeningeos y calcificaciones dentro del tumor. Macroscópicamente se observa un denso engrosamiento en el córtex adyacente, generalmente con un área claramente definida.En este articulo, se describen 3 casos de MA, ninguno de ellos presentaba historia familiar o estigmas de neurofibromatosis (NF). Nosotros realizamos la discusión, haciendo particular énfasis en la presentación clínica y diagnóstico por imágenes, así como en el pronóstico.

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“…MA asociada a meningioma 2,3,7,15,19,21,30,35 . Histológicamente, se trata de una proliferación de células meningoteliales, inmunorreactivas para vimentina y EMA, que puede mostrarse como un engrosamiento focal de la leptomeninge desde la que penetran tabiques en la corteza, o bien como una lesión exclusivamente intracortical sin relación con la leptomeninge.…”

Section: Figura 2 Caso 2: En 2 a Se Aprecia Engrosamiento De La Lepunclassified

Meningioangiomatosis: Descripción de dos casos y revisión de la literatura

et al. 2006

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ResumenLa Meningioangiomatosis (MA) es una lesión benigna intracraneal poco frecuente. La mayoría de los casos son aislados, pero también se han descrito casos asociados a Neurofibromatosis (NF) tipo 2. Los casos asociados a NF suelen ser asintomáticos. Los casos no asociados a NF son sintomáticos, se presentan en niños y adultos jóvenes, y en general afectan a leptomeninge y a corteza cerebral subyacente.En este trabajo se describen 2 casos no asociados a NF en niños de 1 y 7 años de edad, que se manifestaron por crisis, las cuales desaparecieron tras la extirpación de la lesión. Histológicamente las lesiones eran de predominio celular en un caso y de predominio fibro-hialino en el otro.De la revisión de la literatura se concluye que las meningioangiomatosis no asociadas a NF suelen ser lesiones únicas, clínicamente suelen presentarse con crisis convulsivas, y pueden verse asociadas a otras patologías, fundamentalmente a meningiomas.Histológicamente las lesiones corresponden a una proliferación celular de hábito meningotelial que se dispone alrededor de los vasos corticales. A pesar de que todos los casos tienen características comunes, existe un amplio espectro de formas histológicas, que abarca desde casos más celulares hasta casos más fibrosos con calcificaciones. Estas diferencias podrían corresponder a diferentes estadios evolutivos de la lesión. La extirpación de la lesión conlleva la desaparición de los sínto-mas.PALABRAS CLAVE: Corteza cerebral. Hamartoma, Leptomeninge. Meningioangiomatosis. Meningioma. Tumor. Meningioangiomatosis: report of two cases and literature review SummaryMeningioangiomatosis (MA) is a rare benign intracraneal lesion. The majority of cases are sporadic although the association of this lesion with familial neurofibromatosis (NF) type 2 is well known. NF-associated MA may be multifocal and is often asymptomatic and diagnosed at autopsy. Non-associated cases are usually symptomatic, occurs in children and young adults and frequently arise in leptomeninges and underlying cerebral cortex.In the present work, we describe two new non-associated cases of MA in two boys, seven and one year old with seizures that disappeared after surgical excision.Histopathologically, the lesion was predominantly cellular in one case and more fibrous in the other.From the literature review we concluded that sporadic cases present as single lesions which manifest by seizures or persistent headaches. Rarely MA has been described to coexist with meningiomas.Histopathologically IntroducciónLa meningioangiomatosis (MA) es una lesión intracraneal benigna poco frecuente, que suele presentarse en niños

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Childhood meningiomas associated with meningioangiomatosis: report of five cases and literature review

Cited by 58 publications

References 20 publications

Cystic Meningioangiomatosis

Cystic Meningioangiomatosis

Meningioangiomatosis: clinical-radiological features and surgical outcome

Meningioangiomatosis: Descripción de dos casos y revisión de la literatura

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