Childhood malaria in a region of unstable transmission and high human immunodeficiency virus prevalence

Grimwade, Kate; French, Neil; Mbatha, Daniel D; Zungu, Dawn D; Dedicoat, Martin; Gilks, Charles F.

doi:10.1097/01.inf.0000101188.95433.60

Cited by 76 publications

(50 citation statements)

References 15 publications

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“…IPT with SP must be given monthly in order to achieve the same improvements in birth weight as 8-12 weekly administrations in HIV-negative pregnant women. Compared with HIV-negative nonimmune patients, more severe malaria is seen in HIV-infected nonimmune patients, and severely immunocompromised HIV-infected patients in high-transmission settings have higher parasite densities (44,45). This suggests that the immunosuppression associated with HIV infection can affect the control of malaria-parasite numbers and would therefore compromise the effect of antimalarial immunity in reducing the selection and spread of antimalarial drug resistance.…”

Section: Hiv Infectionmentioning

confidence: 94%

Antimalarial drug resistance

White¹

2004

J. Clin. Invest.

901

485

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Section: Hiv Infectionmentioning

confidence: 94%

Antimalarial drug resistance

White¹

2004

J. Clin. Invest.

901

485

View full text Add to dashboard Cite

“…Reported figures on the prevalence of malaria/HIV co-infections vary from one part of the country to another ranging from 29.4% in Douala, the economic capital [4] to 2.24% in Bamenda, the regional capital of the North West Region [5]. Some studies have suggested that repeated infections with malaria are associated with a rapid decline in CD4+ T lymphocytes over time while co-infections of malaria with HIV lead to more episodes of symptomatic [6] and even complicated malaria including death [7][8][9][10]. However, there is generally limited data on these aspects of malaria infection in HIV/AIDS patients in relation to CD4+ T lymphocyte count levels in Southwest Cameroon and such data is needed for proper control measures to be planned by health authorities.…”

Section: Introductionmentioning

confidence: 99%

Malaria in HIV/AIDS Patients at Different CD4+ T Cell Levels in Limbe, Cameroon

Kimbi¹

2012

J Bacteriol Parasitol

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HIV infection has resulted in an increased risk of severe malaria and death, because the odds of parasitaemia and risk of malaria fever increase with decreasing CD4+ T cell count and increasing viral load. A cross-sectional study was conducted on 203 HIV/AIDS patients to determine the pattern of malaria infection, anaemic status and the outcome of ARV therapy vis-à-vis malaria treatment at different CD4+ T cell levels of the patient. Participants were HIV patients aged ≥ 20 years attending the HIV treatment centre of Limbe Regional Hospital, Cameroon. Clinical manifestations of malaria in patients were determined using a structured questionnaire. Their CD4+ T cell count and haemoglobin level were determined using the FACS count method. Malaria prevalence and density were determined from Giemsa-stained blood films. Clinical manifestations of malaria increased with decreasing CD4+ T cell counts. There was a negative correlation between malaria severity and decreasing CD4+ T cell counts. A significantly greater proportion (p<0.01) of patients had moderate anaemia. Cases of anaemia increased significantly (p<0.001) with decreasing CD4+ T cell counts. Declining immunity increases vulnerability to malaria infection and highly active ARV combination therapy has great potential to reduce HIV-related malaria.

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“…Insecticide-treated bed nets (ITNs). Among people with HIV, malaria is more common and more severe (Grimwade, 2003;Whitworth, 2000), and may increase HIV viral load (Kublin 2005) and decrease CD4 cell count (Mermin, 2006b). …”

Section: Introductionmentioning

confidence: 99%

Utilization of a basic care and prevention package by HIV-infected persons in Uganda

et al. 2008

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Opportunistic infections are the leading cause of mortality among HIV-infected people. Several simple interventions prevent illness, prolong life, or prevent HIV transmission from HIV-infected people in Africa. These include: cotrimoxazole prophylaxis; insecticide-treated bed nets; supplies for household water treatment and safe storage; materials promoting family voluntary counselling and testing (VCT); and condoms. We provided these interventions to adults and children with HIV who were members of the AIDS Support Organization in Uganda. To evaluate use of this basic care and prevention package, we surveyed a representative sample of 112 clients of TASO in their homes. Among respondents, 95% reported taking cotrimoxazole everyday, 89% said they had slept under a bednet the night before, 65% reported current treatment of household drinking water, 89% of sexually active respondents reported using condoms, and 96% reported family use of VCT. Household observations verified that use of cotrimoxazole, bednets, and water treatment products were consistent with reported use. This evaluation suggests successful distribution and use of basic care and prevention services at an AIDS organization in Uganda.

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Childhood malaria in a region of unstable transmission and high human immunodeficiency virus prevalence

Abstract: HIV infection was associated with severe/complicated malaria, although the magnitude of the effect may be relatively small. Given that both malaria and HIV are widespread in Africa, even small effects may generate significant morbidity and mortality and major public health consequences.

Cited by 76 publications

References 15 publications

Antimalarial drug resistance

Antimalarial drug resistance

Malaria in HIV/AIDS Patients at Different CD4+ T Cell Levels in Limbe, Cameroon

Utilization of a basic care and prevention package by HIV-infected persons in Uganda

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