Childhood Hygienic Practice and Family Education Status Determine the Prevalence of <i>Helicobacter pylori</i> Infection in Iran

Nouraie, Mehdi; Latifi‐Navid, Saeid; Rezvan, H; Radmard, A.; Maghsudlu, Mahtab; Zaer-Rezaii, Hanieh; Amini, S.; Siavoshi, Farideh; Malekzadeh, Reza

doi:10.1111/j.1523-5378.2009.00657.x

Cited by 90 publications

(73 citation statements)

References 30 publications

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“…69.0% in Tehran and 79.4% in Kerman (14,15). This may be due to the fact that those studies were not population-based; only volunteers or referrals to clinics had been examined.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of Helicobacter pylori Infection evaluated by Stool antigen test in Khuzestan Province since September to October 2009, south-west of Iran: a population based study

Talaiezadeh

Borhani

Moosavian

et al. 2013

Jundishapur J Microbiol

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Background: Although infection with Helicobacter pylori is a global health problem, its prevalence is different among countries. Serologic tests for the diagnosis of H. pylori infection are limited by low accuracy rates and lack of validation. Recent studies indicate that the stool antigen test has an acceptable level of accuracy. Objectives: Our objective was to investigate the prevalence of H. pylori infection in Khuzestan province, south-west of Iran by stool antigen test and to evaluate possible risk factors for the H. pylori infection. Patients and Methods: In this study, from September to October 2009, 861 healthy individuals aged 0-80 years were sampled by cluster sampling from 4.5 million inhabitants of the province. Infection with H. pylori was evaluated by detection of H. pylori antigens in stool (HpSA). Epidemiologic data of each subject were determined by filling up a questionnaire. Results: The overall HpSA positivity was (53.5%, CI 95% = 50.2-56.84%) and the mean age of infected cases was greater than that of non-infected ones (29.2 yrs vs. 24.5 yrs) (P < 0.001). HpSA positivity increased with age. The peak prevalence was reached in the 41-50 years age group (66%). No association was detected between H. pylori positivity and gender. Additionally, there was no significant relationship between H. pylori infection and previous hospital admission, gastrointestinal symptoms, and living area (P > 0.05). Conclusions: H. pylori infection is highly prevalent (57%) in Khuzestan province, south-west of Iran. Low educational levels, low socioeconomic jobs, and increasing age were related to high prevalence of H. pylori infection in this area.

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“…69.0% in Tehran and 79.4% in Kerman (14,15). This may be due to the fact that those studies were not population-based; only volunteers or referrals to clinics had been examined.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of Helicobacter pylori Infection evaluated by Stool antigen test in Khuzestan Province since September to October 2009, south-west of Iran: a population based study

Talaiezadeh

Borhani

Moosavian

et al. 2013

Jundishapur J Microbiol

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“…The prevalence of H pylori infection is 69% in Iran (Nouraie et al, 2009). Phylogenetic analysis performed in Iran has shown that Iranian strains have probably been influenced by genetic exchange from neighboring countries, so that some researchers have suggested Iranian H pylori strains to be a subset of HpEurope population (Latifi-Navid et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori vacA d1 Genotype Predicts Risk of Gastric Adenocarcinoma and Peptic Ulcers in Northwestern Iran

Basiri¹,

Safaralizadeh²,

Bonyadi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: There is a close relationship between Helicobacter pylori (H pylori)-specific factors and different gastroduodenal diseases. The present study aimed to investigate the prevalence of vacA d1, d2 genotypes in the H pylori isolates from patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and gastritis in East Azerbaijan region, where the incidence of gastric cancer (GC) is high. Strains isolated from this area are likely to be of European ancestry. Materials and Methods: In this study, genotyping of the vacA d region of 115 isolates obtained from patients with different gastrodoudenal diseases was accomplished by PCR methods. In addition to PCR amplification of H pylori 16S rDNA, rapid urease tests or histological examination were used to confirm the presence of H pylori in biopsy specimens. Data were collected and analyzed using SPSS version 19. Results: Of the total of 83 H pylori isolates, 36 (43.4%) contained the d1 allele and 47 (56.6%) were subtype d2. The results of the multiple linear/logistic regression analysis showed high correlation between allele d1 and gastric adenocarcinoma or PUD. Conclusions: This study suggests that the H pylori vacA d1 genotype helps predict risk for gastric adenocarcinoma and PUD in East Azerbaijan, Iran.

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“…This bacterium plays an important role in the initiation of gastrointestinal diseases, particularly peptic and duodenal ulcers, as well as gastric cancer and lymphoid tissue lymphoma. H. pylori is estimated to inhabit at least half the world's human population (Erzin et al 2006, Huang et al 2009, Nouraie et al 2009). …”

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confidence: 99%

Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients

Rasmussen

Lábio

Gatti

et al. 2010

Mem. Inst. Oswaldo Cruz

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Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection

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Childhood Hygienic Practice and Family Education Status Determine the Prevalence of Helicobacter pylori Infection in Iran

Cited by 90 publications

References 30 publications

Prevalence of Helicobacter pylori Infection evaluated by Stool antigen test in Khuzestan Province since September to October 2009, south-west of Iran: a population based study

Prevalence of Helicobacter pylori Infection evaluated by Stool antigen test in Khuzestan Province since September to October 2009, south-west of Iran: a population based study

Helicobacter pylori vacA d1 Genotype Predicts Risk of Gastric Adenocarcinoma and Peptic Ulcers in Northwestern Iran

Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients

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