Childhood Hodgkin's disease in Uganda.A ten year experience

Olweny, Charles L. M.; Katongole‐Mbidde, Edward; Kiire, C.F.; Lwanga, Stephen K.; Magrath, I. T.; Zlegler, J. L.

doi:10.1002/1097-0142(197808)42:2<787::aid-cncr2820420251>3.0.co;2-4

Cited by 123 publications

(38 citation statements)

References 16 publications

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“…The risk of secondary mass development increases in the years after the diagnosis and the latent period is over 20 years. The incidence especially of breast, thyroid, and skin cancers in childhood, and of gastrointestinal tumors and lung cancers in the adult period, are higher in children who are diagnosed with HL during childhood and survive (32)(33)(34)(35)(36). Reduced-dose involved field radiotherapy has been used in recent years because of the late side effects of radiotherapy.…”

Section: Discussionsupporting

confidence: 86%

Second Malignant Neoplasms in Pediatric Oncology Patients: A Single Center Experience

Tanyıldız¹,

Yeşil²,

Tekgündüz³

et al. 2017

GMJ

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Objective: The pediatric malignancy survival rate has increased with new and intensive treatment modality advancements. This has led to an approximately 70% chance of surviving more than 5 years in children diagnosed with cancer. However, the secondary tumor incidence has also increased with these advances. The patient's quality of life, late side effects, and prevention of secondary malignancies in the future are as important as treating the primary tumor in pediatric cancer patients. Methods: We retrospectively evaluated the charts of 2100 pediatric cancer patients who were diagnosed in our clinic between 1985 and 2012. Results: There were 11 secondary tumors. Male-to-female ratio was 6:5 and median age at diagnosis was 7 years (range, 1 year 3 months-11 years 6 months). Secondary tumor diagnosis was AML in five patients, paraganglioma in one patient, liposarcoma in one patient, rhabdomyosarcoma in one patient, papillary thyroid carcinoma in one patient, malignant fibrous histiocytoma in one patient, and squamous cell carcinoma of the tongue in one patient. AML was the most commonly detected secondary malignancy. Conclusion: We suggest that using less toxic systemic chemotherapy and reduced-dose radiotherapy is increasingly important with targeted treatment modalities to decrease the risk of secondary malignancy.

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Section: Discussionsupporting

confidence: 86%

Second Malignant Neoplasms in Pediatric Oncology Patients: A Single Center Experience

Tanyıldız¹,

Yeşil²,

Tekgündüz³

et al. 2017

GMJ

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“…This rate is significantly higher than that obtained by the Senegalese who, over a period of 11 years, treated seven patients, with six deaths and one lost to follow-up. Our result is comparable to that obtained by Olweny in Uganda who used virtually the same protocol as us (75% for stages I-IIA and 60% for stages IIIB and IV), but our sample is much smaller [9].…”

Section: Discussionmentioning

confidence: 99%

Hodgkin lymphoma at the paediatric oncology unit of Gabriel-Touré teaching Hospital Bamako (Mali): 3 years experience

Togo¹,

Traoré²,

Togo³

et al. 2011

J Afr Cancer

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Introduction: Approximately 20 000 new cases of Hodgkin lymphoma are diagnosed each year in North America and Europe. However in Africa, the incidence of this condition is almost unknown. While publications from western countries and the rest of world are numerous in the literature, few data from Africa about this malignancy are available. The aim of this retro and prospective, unicentric study over 3 years is to describe the epidemiologic, pathologic, clinical and therapeutic aspects of children treated for Hodgkin lymphoma in our paediatric oncology unit of Gabriel-Touré Hospital, Bamako (Mali). Patients and methods: From January 2005 to December 2007, all children under 18 years of age, with histologically proven Hodgkin lymphoma, not previously treated by chemotherapy and HIV negative, were included in this study. Informed consent was obtained from parents. The treatment protocol was the GFAOP (Groupe franco-africain d'oncologie pédiatrique) Hodgkin lymphoma treatment protocol: COPP/ABV (Cyclophosphamid, Vincristin, Prednisone, Procarbazin, Adriamycine, bleomycin and vinblastine). Results: During the study period, 217 cancer cases were diagnosed in our centre. Of these cases, 7 were Hodgkin Lymphoma (0.04%). The average age was 11.7 years. The sex-ratio was 6/1 in favor of boys. 6.71% (5/7) of the patients were stage IIB and 28.6 % (2/7) of the patients were stage IIIB of the Ann-Arbor classification. Histologically, there were 42.8% cases of sclero-nodular subtype, 28.6% of lymphocyte-rich subtype, 14.3 % of mixed cellularity and 14.3% of lymphocyte depleted subtype. After 4 years follow-up, 5 patients (71.4 %) were alive, and 2 patients (28.6 %) had died from drug toxicity. Conclusion: Hodgkin lymphoma is a relatively rare condition in African children which can be cured. Broader multicentric studies are needed for more accurate data on this malignancy. To cite this journal: J. Afr. Cancer 3 (2011).

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“…The mixed cellularity type is also more commonly seen in developing countries. [5][6][7][8][9] Very little has been published about the clinical behavior of the disease in the very young (i.e., those under 6 years of age). In fact, there appears to be no report dealing specifically with pre-school children considered as a separate group.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Results of Treatment of Hodgkin’s Disease in Pre-School Saudi Children

et al. 1990

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Childhood Hodgkin's disease in Uganda.A ten year experience

Cited by 123 publications

References 16 publications

Second Malignant Neoplasms in Pediatric Oncology Patients: A Single Center Experience

Second Malignant Neoplasms in Pediatric Oncology Patients: A Single Center Experience

Hodgkin lymphoma at the paediatric oncology unit of Gabriel-Touré teaching Hospital Bamako (Mali): 3 years experience

Clinical Features and Results of Treatment of Hodgkin’s Disease in Pre-School Saudi Children

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