Childhood growth in boys with congenital hypogonadotropic hypogonadism

Varimo, Tero; Hero, Matti; Laitinen, Eeva-Maria; Miettinen, Päivi J.; Tommiska, Johanna; Känsäkoski, Johanna; Juul, Anders; Raivio, Taneli

doi:10.1038/pr.2015.278

Cited by 20 publications

(15 citation statements)

References 41 publications

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“…Several studies report that adult height in CHH men exceeds the height of healthy control men (127)(128)(129). Other studies show that CHH adolescents, on average, achieve their midparental height (126,130). Studying 41 CHH men, a positive correlation was found between the delay of puberty prior to treatment and adult height, such that 6 years or more of pubertal delay was associated with ~5 cm greater adult height (128).…”

Section: Hallmarks Of Chh In Adolescence In Malesmentioning

confidence: 96%

“…The majority of CHH patients have eunuchoidal proportions with arm spans typically exceeding height by ≥ 5 cm, reflecting the delayed closure of the epiphysis of long bones in the absence of gonadal steroids. The lack of increased sex steroids levels leads to steady linear growth (125) without a growth spurt, however final height is rarely affected (126). Several studies report that adult height in CHH men exceeds the height of healthy control men (127)(128)(129).…”

Section: Hallmarks Of Chh In Adolescence In Malesmentioning

confidence: 99%

“…Growth velocity was recently suggested to help differentiate the different etiologies of delayed puberty (6), but was subsequently shown to offer no additional diagnostic value in separating between CDGP and CHH (121,126).…”

Section: Transient Gnrh Deficiency: Constitutional Delay Of Growth Anmentioning

confidence: 99%

“…The presence of cryptorchidism and/or micropenis strongly argues in favor of CHH, reflecting the absence of gonadotropins and sexual hormones during both fetal life and minipuberty (6,121). In a series of 174 boys referred to a tertiary center for evaluation of delayed puberty, cryptorchidism was present in 36% boys with CHH and only in 2% of boys with CDGP (126).…”

Section: Advance Article: Endocrine Reviewsmentioning

confidence: 99%

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Clinical Management of Congenital Hypogonadotropic Hypogonadism

et al. 2019

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at the modification stage), and do not reflect editorial changes. No corrections/changes to the PDF manuscripts are accepted. Accordingly, there likely will be differences between the Advance Article manuscripts and the final, typeset articles. The manuscripts remain listed on the Advance Article page until the final, typeset articles are posted. At that point, the manuscripts are removed from the Advance Article page. DISCLAIMER: These manuscripts are provided "as is" without warranty of any kind, either express or particular purpose, or non-infringement. Changes will be made to these manuscripts before publication. Review and/or use or reliance on these materials is at the discretion and risk of the reader/user. In no event shall the Endocrine Society be liable for damages of any kind arising references to, products or publications do not imply endorsement of that product or publication.

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Section: Hallmarks Of Chh In Adolescence In Malesmentioning

confidence: 96%

Section: Hallmarks Of Chh In Adolescence In Malesmentioning

confidence: 99%

Section: Transient Gnrh Deficiency: Constitutional Delay Of Growth Anmentioning

confidence: 99%

Section: Advance Article: Endocrine Reviewsmentioning

confidence: 99%

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Clinical Management of Congenital Hypogonadotropic Hypogonadism

et al. 2019

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“…Boys with congenital hypogonadotrophic hypogonadism who completely lack the postnatal T surge show stunted linear growth during minipuberty. 25 A temporary increase in GV has been reported in infants and prepubertal boys exposed to repeated doses of intramuscular T for treatment of micropenis. 26 These findings further support the view that androgens have a potential to enhance growth, either directly or through aromatization, also during infancy.…”

Section: Figurementioning

confidence: 99%

Transient Postnatal Gonadal Activation and Growth Velocity in Infancy

et al. 2016

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BACKGROUND AND OBJECTIVE: Transient activation of the hypothalamic-pituitary-gonadal axis with a sex steroid surge is observed in boys and girls during the first months of life. However, the role of sex steroids in the regulation of growth has not been substantiated in infancy. We tested the hypothesis that testosterone (T) surge, known to be higher in infant boys than in girls during the transient postnatal gonadal activation regulates linear growth in infants.

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Minipuberty in Klinefelter syndrome: Current status and future directions

Aksglæde

Davis

Ross

et al. 2020

American J of Med Genetics Pt C

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Klinefelter syndrome is highly underdiagnosed and diagnosis is often delayed. With the introduction of non‐invasive prenatal screening, the diagnostic pattern will require an updated description of the clinical and biochemical presentation of infants with Klinefelter syndrome. In the first months of life, the hypothalamic–pituitary–gonadal (HPG)‐axis is transiently activated in healthy males during the so‐called minipuberty. This period represents a “window of opportunity” for evaluation of the HPG‐axis before puberty and without stimulation tests. Infants with Klinefelter syndrome present with a hormonal surge during the minipuberty. However, only a limited number of studies exist, and the results are contradictory. Further studies are needed to clarify whether infants with Klinefelter syndrome present with impaired testosterone production during the minipuberty. The aim of this review is to describe the clinical and biochemical characteristics of the neonate and infant with Klinefelter syndrome with special focus on the minipuberty and to update the clinical recommendations for Klinefelter syndrome during infancy.

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Childhood growth in boys with congenital hypogonadotropic hypogonadism

Cited by 20 publications

References 41 publications

Clinical Management of Congenital Hypogonadotropic Hypogonadism

Clinical Management of Congenital Hypogonadotropic Hypogonadism

Transient Postnatal Gonadal Activation and Growth Velocity in Infancy

Minipuberty in Klinefelter syndrome: Current status and future directions

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