Childhood Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C: Importance of Body Composition

Miliku, Kozeta; Bakker, Hanneke; Dorresteijn, Eiske M.; Cransberg, Karlien; Franco, Oscar H.; Felix, Janine F.; Jaddoe, Vincent W.V.

doi:10.1159/000463395

Cited by 21 publications

(21 citation statements)

References 29 publications

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“…This present study also found a negative correlation between the anthropometric parameters and serum Cystatin C. This suggested that Cystatin C may not be independents of anthropometric indices as earlier documented by some researchers [21,22]. In keeping with this finding is a recent study that involved a large cohort of children (4,305 children) in the Netherlands that demonstrated the influence of body composition on both the value of serum Cystatin C and estimated GFR [32].…”

Section: Discussionsupporting

confidence: 89%

Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns

Ibrahim

Soladoye

Adedoyin

et al. 2019

Alexandria Journal of Medicine

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Background: The value of Cystatin C as a biomarker of Glomerular filtration rate (GFR) among African newborns is unknown, due to paucity of studies, restricting the measurement of GFR in this population of newborns to creatinine clearance despite its limitations. This study was therefore conducted to estimate GFR from serum Cystatin C in a population of Nigerian newborns and explored the relationship with anthropometrics. Methods: This was a cross-sectional, analytical study. A total of 60 healthy preterm and 30 healthy term babies were recruited at a tertiary hospital in North-central, Nigeria. Serum Cystatin C was determined using ELISA according to standard methods. Anthropometric measurements were done with standard methods. The GFR was estimated using Zappitelli's equation. Data were analyzed using SPSS Version 20, and p-value < 0.05 was considered significant. Results: Mean serum Cystatin C was 1.20 ± 0.33 (range 0.80-2.20) mg/L with comparable values in males and females (1.19 ± 0.35 vs 1.15 ± 0.31 mg/L, p = 0.481)). Mean serum Cystatin C among preterm babies were higher than term babies (1.31 ± 0.36 vs 1.01 ± 0.11 mg/L, p = < 0.001). Mean estimated GFR was 65.36 ± 16.9 ml/min/1.73 2 and was comparable in males and females (64.39 ± 17.95 vs 66.52 ± 15.76 ml/min/1.73 m 2 ,p = 0.555). Estimated GFR was lower among preterm than term babies (60.10 ± 17.53 vs 75.89 ± 9.1 ml/min/1.73 m 2 , p = < 0.001). Serum cystatin C and estimated GFR moderately correlated with gestational age and anthropometrics (length, occipitofrontal circumference and weight). Conclusions: Serum cystatin C as a biomarker GFR among newborns is low compared with most studies done out of Africa. The serum cystatin C and estimated GFR correlated with the gestational age and anthropometric parameters. The findings relationship between the serum Cystatin C, estimated GFR and anthropometrics among the newborns suggested a need for more studies. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 89%

Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns

Ibrahim

Soladoye

Adedoyin

et al. 2019

Alexandria Journal of Medicine

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“…The low correlation coefficient of r 2 = 0.003 ( p < 0.001) may explain why no correlation with lean or fat mass percentage was found by Miliku et al in 6-year-old children [23, 44]. The estimation of the GFR based on sCrea must also consider the body height (Schwartz et al) [4] during entire childhood and adolescence.…”

Section: Discussionmentioning

confidence: 99%

Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage

et al. 2018

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BackgroundThis study aims to establish age- and gender-specific cystatin C (CysC) reference values for healthy infants, children, and adolescents and to relate them to pubertal stage, height, weight, and body mass index (BMI).MethodsSerum CysC and creatinine levels of 6217 fasting, morning venous blood samples from 2803 healthy participants of the LIFE Child study (age 3 months to 18 years) were analyzed by an immunoassay. Recruitment started in 2011; 1636 participants provided at least one follow-up measurement. Percentiles for CysC were calculated. Age- and gender-related effects of height, weight, BMI, and puberty status were assessed through linear regression models.ResultsOver the first 2 years of life, median CysC levels decrease depending on height (ß = − 0.010 mg/l/cm, p < 0.001) and weight (ß = − 0.033 mg/l/kg, p < 0.001) from 1.06 to 0.88 mg/l for males and from 1.04 to 0.87 mg/l for females. Following the second year of age, the levels remain stable for eight years. From 11 to 14 years of age, there is an increase of median CysC levels in males to 0.98 mg/l and a decrease in females to 0.86 mg/l. The change is associated with puberty (ß = 0.105 mg/l/Tanner stage, p < 0.001 in males and ß = − 0.093 mg/l/Tanner stage, p < 0.01 in females) and in males with height (ß = 0.003 mg/l/cm, p < 0.001).ConclusionsCysC levels depend on age, gender, and height, especially during infancy and puberty. We recommend the use of age- and gender-specific reference values for CysC serum levels for estimating kidney function in clinical practice.Electronic supplementary materialThe online version of this article (10.1007/s00467-018-4087-z) contains supplementary material, which is available to authorized users.

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“…CysC appears to be more sensitive than Cr for patients with declining GFR in chronic liver disease (3)(4)(5). However, CysC positively correlates with body mass index (BMI) and is more strongly correlated with waist circumference and inflammation (6)(7)(8). In patients with chronic kidney disease (CKD) with eGFR >60 ml/min/m 2 , the medium value of Cr was well within the normal range, whereas the median value of CysC was found to be higher than the upper reference limit (7).…”

Section: Introductionmentioning

confidence: 99%

Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease

et al. 2020

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Serum creatinine (Cr)-based glomerular filtration rate (CrGFR) is overestimated in liver disease. The present study evaluated whether the difference in CrGFR and cystatin C (CysC) GFR (dGFR) is significant in liver disease. The Cr-to-CysC ratio and sarcopenia index (SI) have been reported to correlate with muscle volume. An estimated total body muscle mass with Cr, CysC and calculated body muscle mass (CBMM) has also been reported to correlate with muscle mass. The applicability of dGFR, SI and CBMM for liver disease were evaluated. A total of 313 patients with liver damage were evaluated for Child-Pugh score, albumin-bilirubin (ALBI) score, model for end-stage liver disease, fibrosis-4, Cr, CysC, Cr-based estimated GFR (CreGFR), CysCGFR and grip strength. Of the 313 patients, 199 were evaluated using cross-sectional computed tomography (CT) of the third lumbar vertebra to determine the skeletal muscle (SM) mass. dGFR, CBMM and SI were compared to liver damage, muscle strength and muscle mass. In the 313 patients, dGFR was correlated with age, ALBI and grip strength; CBMM was correlated with body mass index (BMI) and grip strength; and SI was correlated with BMI and grip strength. In patients evaluated with CT, the correlation coefficients for CBMM and SI with SM were 0.804 and 0.293, respectively. Thus, CBMM and SI were associated with sarcopenia. The relationship between dGFR and ALBI does not differ with different grades of CrGFR-based chronic kidney disease (CKD). dGFR is a marker of liver damage and muscle strength regardless of CKD. CBMM and SI are markers for sarcopenia in liver disease.

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Childhood Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C: Importance of Body Composition

Cited by 21 publications

References 29 publications

Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns

Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns

Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage

Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease

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