Childhood diarrhoea and its association with enteropathogenic Esch. coli

Khanna, Kunal; Ramanathan, Arvind; Puri, Rajeev; Bhatia, Vinay; Sundararaj, Thilak

doi:10.1007/bf02892241

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…There is no recent information regarding the occurrence of the "classic" EPEC in Finland; in Sweden they have been found only sporadically (1). This is in contrast with the situation in many other countries (5,12,15).…”

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confidence: 73%

Enterotoxigenic and Invasive Escherichia Coli as Causes of Childhood Diarrhoea in Finland

1980

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E. coli was considered as the possible aetiologic agent in 16 cases (5.7%) of 283 hospital admissions for diarrhoea. One invasive strain was isolated from a case with exudative diarrhoea. Four heat-labile (LT) enterotoxin-producing strains were found in relatively mild cases of diarrhoea. Eleven strains belonged to "classic" pathogenic serotypes (EPEC); 9 of these were endemic cases and 2 associated with travel. Of the latter, 1 strain (078) was also found to produce heat-stable (ST) enterotoxin detectable by infant mouse assay. Although EPEC are now found much less frequently than 20 years ago, E. coli as a whole may still be the most common bacterial aetiology of childhood diarrhoea in Finland.

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confidence: 73%

Enterotoxigenic and Invasive Escherichia Coli as Causes of Childhood Diarrhoea in Finland

1980

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“…The higher incidence of diarrhoea had also been reported by other workers. 16,17 Newborns and infants because of their immature immunological response are particularly susceptible to infection especially if they are not breast fed. Moreover, they are easily prone to dehydration and electrolyte imbalance because of greater water content and increased insensible water loss from their body.…”

Section: Discussionmentioning

confidence: 99%

Study of Electrolyte Imbalance in Children Suffering From Acute Gastroenteritis of Under 5 Age Group

Pratima¹,

M²

2018

jebmh

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BACKGROUND Acute Gastroenteritis is a leading cause of illness and death amongst children in developing countries. Serum electrolyte disturbances are common in under five children with acute gastroenteritis resulting in morbidity and mortality. The aim of the study was to assess the type and prevalence of electrolyte imbalance in under five children with acute gastroenteritis. MATERIALS AND METHODS This was a descriptive, hospital based cross-sectional study of children below five years age group with dehydration due to acute gastroenteritis. Serum electrolyte profiles were determined. RESULTS Out of 80 children studied, 44 (55%) children were aged below 12 months, 20 (25%) children were between 13 to 36 months, and 16 (20%) children were between 3 to 5 years. The frequencies of various types of dehydration were hyponatraemic in 49 (62.5%) children, isonatremic in 31 (38.75%) children and no case of hypernatremia. Hypokalaemia was observed in 21 (26.5%) children. The overall case fatality rate was 6 (7.5%). All the children who died, were below 36 months. All were acidotic. Two had features of acute renal failure. Others died because of associated infection and peripheral circulatory failure. CONCLUSION Hyponatremia, Hypokalaemia were the common electrolyte abnormalities in acute gastroenteritis and were responsible for most deaths.

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“…Resistance of Enterpathogenic bacteria to commonly prescribed antibiotics is increasing both in the developing as well as developed countries and resistance has emerged even to the newer, more potent antimicrobial agents (8). …”

Section: Introductionmentioning

confidence: 99%

Role of Enteropathogenic Escherichia Coli in Paediatric Diarrhoeas in South India

Tilak¹,

Mudaliar²

2012

Mater Sociomed

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Background:Enteropathogenic Escherichia coli(EPEC) is a major cause of diarrhoea in children below 5 years of age. Serotyping is classical method for identification of EPEC strains. But serotypic markers are rarely sufficient to reliably identify the strains as Escherichia coli. Introduction of PCR methodology which depends on detection of virulence factors has provided a practical and rapid way of detecting diarrhoeagenic Esch.coli. Multiantibiotic resistant EPEC strains are a common phenomenon with world wide extension. Moreover for the selection of appropriate therapy of dirrhoeas, knowledge of local antimicrobial therapy pattern plays an important role.Objectives:To study the role of EPEC in Paediatric diarrhoea by both Serogrouping and Molecular characterisation by PCR and to analyse the antibiotic susceptabililty patterns of EPEC strains in our area.Materials and methods:Prospective study of stool samples collected from children with diarrhoea and without diarrhoea who were below 5 years of age was conducted from May to November 2011. Escherichia.coli isolates were identified by Microscopy, Culture and Biochemical reactions. Among the Escherichia coli isolates, EPEC isolates were identified by Serogrouping. Escherichia coli isolates were also subjected to Molecular characterisation by Multiplex PCR assay and those isolates which showed pathogenic genes were futher serotyped. Antibiotic susceptibility pattern of EPEC isolates was determined by CLSI guidelines.Results:Among the Escherichia coli isolates 36.8% in the diarrhoeal group and none of them from the nondiarrhoeal group were identified as EPEC by serogrouping. 73.3% of the EPEC isolates were below 2 years of age and no much difference in the sex distribution was observed. Mild to moderate dehydration and feccal leuckocytes were seen in 59.9% and 56.6% of isolates respectively. High resistance to Nalidixic acid, Ampicillin, Cotrimoxazole, Ciprofloxacin and Norfloxacin was observed in the diarrhoeal group and resistance to only ampicillin was seen in the nondiarrhoeal group. In the diarrhoeal group 38.8% of Escherichia coli were EAEC and no other diarrhoeagenic Escherichia coli group was found by molecular characterisation. In the nondiarrhoeal Escherichia coli strains, 46.6% showed EAEC genes. EAEC strains in the diarrhoeal group belonged to multiple serotypes, the most common serotype being ONT and in the nondiarrhoeal group, 85.7% were of a single serotype, the most common isolate being O153. Among the Escherichia coli isolates which agglutinated with EPEC polyvalent antisera, 33.3% were positive for Enteroaggregative genes. (Table 1).Conclusion:EPEC is still an important pathogen in paediatric diarrhoeas. O serogrouping can still be relied upon for detection of EPEC. Dehydration is one of the clinical features of EPEC diarrhoea. Fluoroquinolones should only be prescribed in children as second line antibiotics. EAEC are present in classical ‘ O ’ serogroups. Serotype O 153 has an increasing potential for asymptomatic carrier state in children below 5...

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Childhood diarrhoea and its association with enteropathogenic Esch. coli

Cited by 5 publications

References 4 publications

Enterotoxigenic and Invasive Escherichia Coli as Causes of Childhood Diarrhoea in Finland

Enterotoxigenic and Invasive Escherichia Coli as Causes of Childhood Diarrhoea in Finland

Study of Electrolyte Imbalance in Children Suffering From Acute Gastroenteritis of Under 5 Age Group

Role of Enteropathogenic Escherichia Coli in Paediatric Diarrhoeas in South India

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