Childhood Cancers: Hepatoblastoma

Herzog, Cynthia E.; Andrassy, Richard J.; Eftekhari, Farzin

doi:10.1634/theoncologist.5-6-445

Cited by 148 publications

(116 citation statements)

References 57 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…11,[18][19][20][21]23,24 Risk factors for hepatoblastoma are not well characterized. Hepatoblastoma has been shown to be associated with Beckwith-Weidmann syndrome 25,26 hemihypertrophy, and familial adenomatous polyposis, none of which have unique ICD-9 codes. 27 The relatively low incidence of these conditions did not allow us to examine their association with hepatoblastoma in the multiple cause of death database.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of primary hepatic malignancies in U.S. children

et al. 2003

View full text Add to dashboard Cite

The epidemiology of primary hepatic malignancies in U.S. children is poorly characterized. We analyzed the incidence, mortality, and characteristics of primary hepatic malignancies in U.S. residents less than 20 years of age. Fatal primary hepatic malignancies in persons less than 20 years of age, between 1979 and 1996, were identified using the multiple-cause-ofdeath database (National Center for Health Statistics). Histologically confirmed primary hepatic malignancies occurring between 1973 and 1997 were identified using the Surveillance, Epidemiology, and End Results (SEER) database. Between 1979 and 1996, 918 primary hepatic malignancy deaths (average, 0.7/1,000,000/year) were reported nationally among persons less than 20 years of age; rates were higher among Asians and among foreignborn children. Between 1973 and 1997, 271 primary hepatic malignancy cases were reported to SEER among persons less than 20 years of age, of which 184 (67%) and 83 (31%) were hepatoblastoma and hepatocellular carcinoma, respectively. Among children less than 5 years of age, hepatoblastoma accounted for 91% of primary hepatic malignancy cases, whereas among those 15 to 19 years of age, hepatocellular carcinoma accounted for 87% of cases. Five-year survival for hepatoblastoma was 52%, compared with 18% for hepatocellular carcinoma. In the SEER sites, between 1973 and 1977 and 1993 and 1997, hepatoblastoma rates increased (0.6 to 1.2/1,000,000, respectively), while hepatocellular carcinoma rates decreased (0.45 to 0.29/1,000,000, respectively). In conclusion, histologically confirmed hepatocellular carcinoma was reported in children less than 5 years of age, also, where hepatoblastoma is the predominant primary hepatic malignancy. Hepatocellular carcinoma has worse survival rates than hepatoblastoma, and its incidence has not increased. Better maintenance of databases may provide information about associated factors behind this unexpected occurrence. (HEPATOLOGY 2003;38:560-566.) P rimary hepatic malignancies are rare in children. 1

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology of primary hepatic malignancies in U.S. children

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Hepatoblastoma can be classified into epithelial (56%) or mixed forms (epithelial and mesenchymal, 44%). The epithelial form further regroups into pure fetal (31%), embryonal (19%), macrotrabecular (3%) and small-cell undifferentiated (3%) subtypes (8), with the latter being associated with poor prognosis (9).…”

Section: Abstract Hepatoblastoma Is the Most Common Pediatric Liver mentioning

confidence: 99%

“…Obviously, the ultimate goal would be to decrease the concentration of cytostatics given their potential for severe side-effects, especially when given at high doses. In the treatment of childhood cancer, particularly, doxorubicin is responsible for cardiotoxicity (71), whereas cisplatin causes nephrotoxicity and ototoxicity (8).…”

Section: Therapeutic Innovations In Hepatoblastoma the Nk1r As A Tumomentioning

confidence: 99%

Therapeutic Innovations for Targeting Hepatoblastoma

Garnier

Ilmer

Kappler

et al. 2016

View full text Add to dashboard Cite

“…Usually, the disease is diagnosed during the first three years of a child's life (2). The etiology of HB is unclear, but has been associated with Beckwith-Wiedemann syndrome, familial adenomatosis polypi and low birth weight (3). The primary treatment for HB is surgical resection, and the use of pre-resection chemotherapy may increase the likelihood of a resectable tumor (3).…”

Section: Introductionmentioning

confidence: 99%

“…The etiology of HB is unclear, but has been associated with Beckwith-Wiedemann syndrome, familial adenomatosis polypi and low birth weight (3). The primary treatment for HB is surgical resection, and the use of pre-resection chemotherapy may increase the likelihood of a resectable tumor (3). Therefore, the pathogenesis of HB requires urgent understanding.…”

Section: Introductionmentioning

confidence: 99%

Regulatory network analysis of genes and microRNAs in human hepatoblastoma

Guo

Sun

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Hepatoblastoma (HB) is a common type of primary tumor in children. Previous studies have examined the expression of genes, including transcription factors (TFs), target genes, host genes and microRNAs (miRNAs or miRs) associated with HB. However, the regulatory pathways of miRNAs and genes remain unclear. In the present study, a novel perspective is proposed, which focuses on HB and the associated regulatory pathways, to construct three networks at various levels, including a differentially expressed network, an associated network and a global network. Genes and miRNAs are considered as key factors in the network. In the three networks, the associations between each pair of factors, including TFs that regulate miRNAs, miRNAs that interact with target genes and miRNAs that are located at host genes, were analyzed. The differentially expressed network is considered to be the most crucial of the three networks. All factors in the differentially expressed network were mutated or differentially expressed, which indicated that the majority of the factors were cancerogenic factors that may lead to HB. In addition, the network contained numerous abnormal linkages that may trigger HB. If the expression of each factor was corrected to a normal level, HB may be successfully treated. The associated network included more HB-associated genes and miRNAs, and was useful for analyzing the pathogenesis of HB. By analyzing these close associations, the first and the last factor of the regulatory pathways were revealed to have important roles in HB. For example, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) was observed to regulate Homo sapiens (hsa)-miR-221, hsa-miR-18a and hsa-miR-17-5p, but no miRNAs targeted MYCN. In conclusion, the pathways and mechanisms underlying HB were expounded in the present study, which proposed a fundamental hypothesis for additional studies.

show abstract

Childhood Cancers: Hepatoblastoma

Cited by 148 publications

References 57 publications

Epidemiology of primary hepatic malignancies in U.S. children

Epidemiology of primary hepatic malignancies in U.S. children

Therapeutic Innovations for Targeting Hepatoblastoma

Regulatory network analysis of genes and microRNAs in human hepatoblastoma

Contact Info

Product

Resources

About