Childhood cancer incidence in South Africa, 1987 - 2007

Stefan, Daniela Cristina; Stones, DK; Wainwright, R. D.; Kruger, Mariana; Davidson, Alan; Poole, Janet; Hadley, G. P.; Forman, David; Colombet, Murielle; Steliarova‐Foucher, Eva

doi:10.7196/samj.2015.v105i11.9780

Cited by 40 publications

(55 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was followed by retinoblastomas, neuroblastomas, central nervous system tumours and soft tissue sarcomas. 20 Even though these findings cannot directly be compared to the distribution of malignant tumours in our study; this study described a lower distribution of patients diagnosed with neuroblastoma, which was not in keeping with the distribution reported in high-income countries. These findings suggested that the distribution of malignant tumours may vary in different ethnic groups and geographical locations and this might account for the low number of patients diagnosed with neuroblastomas in our study.…”

Section: Discussioncontrasting

confidence: 83%

“…20 Although this study included all children diagnosed with malignancies before the age of 14 years, the patient population was divided into groups, with one only including patients from birth to 4 years. 20 This study reviewed patients diagnosed with haematological malignancies and malignant solid tumours; however, the most frequently diagnosed malignant solid tumours in this age group were renal tumours. This was followed by retinoblastomas, neuroblastomas, central nervous system tumours and soft tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal tumours: A single centre review

Schickerling

2017

S. Afr. j. oncol.

View full text Add to dashboard Cite

Background: Neonatal tumours, occurring within 28 days of life, are associated with a favourable outcome in high-income countries. Limited data are available on neonatal tumours in low- and middle-income countries. Aim: We aimed to create awareness of neonatal tumours in a middle-income country, by identifying the most common tumours diagnosed to determine whether there was a delay to presentation or diagnosis at the Paediatric Oncology unit, to identify possible areas of improvement and increase overall survival. Setting: Chris Hani Baragwanath Academic Hospital Paediatric Oncology unit. Methods: A retrospective case series was performed collecting data on 60 neonates diagnosed with a tumour over a 25-year period (1 January 1988 to 31 December 2012). Descriptive statistical analysis using percentages and medians were used. Kaplan–Meier analysis was used to calculate survival. Results: Germ cell tumours were identified as the most common neonatal tumours diagnosed 29/60 (48.3%), whereas malignant soft tissue tumours were the most common malignant tumours identified. The median delay to presentation was 7 days, the median diagnostic delay was 11 days and the median overall delay was 30 days. The overall 5-year survival rate was 67.3%, with an overall 5-year survival of 54.1% of neonates diagnosed with a malignant tumour. Conclusion: A large percentage of neonates diagnosed with malignant tumours in highincome countries can be successfully treated and cured. Clinicians involved in the care of neonates need to be better acquainted with disease-specific signs of neonatal tumours to allow for early detection and referral to a Paediatric Oncology unit.

show abstract

Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Neonatal tumours: A single centre review

Schickerling

2017

S. Afr. j. oncol.

View full text Add to dashboard Cite

show abstract

“…Of the five datasets classified as sub-Saharan African in IICC-2, only one (from Namibia) reported a lower overall incidence rate than the South African registry in IICC-3. The possible reasons for the low rates in South Africa are discussed elsewhere 18 . Second, the implementation of antiretroviral therapy in some areas affected by HIV 19 has contributed to a decrease in incidence of Kaposi's sarcoma.…”

Section: Discussionmentioning

confidence: 99%

International incidence of childhood cancer, 2001–10: a population-based registry study

Steliarova‐Foucher¹,

Colombet²,

Ries³

et al. 2017

The Lancet Oncology

Self Cite

1,128

890

View full text Add to dashboard Cite

SummaryBackgroundCancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control.MethodsThis population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s.FindingsOf 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years.InterpretationThis unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research.FundingInternational Agency for Research on Cancer and the Union for International Cancer Control.

show abstract

“…From Stefan et al [13] comes a first report from the South African Children's Tumour Registry (SACTR), a paediatric cancer registry that covers the entire country. The article provides estimates of cancer incidence and discusses the challenges of cancer surveillance and control in childhood populations in a middle-income country like ours, and constitutes an invaluable resource of information for policy planning and research.…”

Section: Childhood Cancermentioning

confidence: 99%

Editor's Choice

Seggie

2015

S Afr Med J

View full text Add to dashboard Cite

Childhood cancer incidence in South Africa, 1987 - 2007

Cited by 40 publications

References 11 publications

Neonatal tumours: A single centre review

Neonatal tumours: A single centre review

International incidence of childhood cancer, 2001–10: a population-based registry study

Editor's Choice

Contact Info

Product

Resources

About