Childhood Cancer Incidence in Delhi, 1996 – 2000

Tyagi, Brij Bhushan; Manoharan, N; Raina, Vinod

doi:10.1055/s-0041-1733185

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…ALL is the most frequent malignancy accounting for 85% of all childhood leukaemia. 32 33 34 35 36 B-ALL constituted 76% of all ALL that comprised of predominantly CALLA positive ALL in 73%, early precursor pro B-ALL in 3%. 33 The World Health Organization classification of hematopoietic and lymphoid tissue (2017) defines B lymphoblastic leukemia/lymphoma into various subtypes including “B lymphoblastic leukemia/lymphoma with 7 recurrent genetic abnormalities.” 1 Conventional cytogenetics, interphase FISH, RT-PCR find application in the detection of recurrent genetic abnormalities as they play a pivotal role in prognostication, selection of therapy, and response to treatment.…”

Section: Discussionmentioning

confidence: 99%

“…33 The World Health Organization classification of hematopoietic and lymphoid tissue (2017) defines B lymphoblastic leukemia/lymphoma into various subtypes including “B lymphoblastic leukemia/lymphoma with 7 recurrent genetic abnormalities.” 1 Conventional cytogenetics, interphase FISH, RT-PCR find application in the detection of recurrent genetic abnormalities as they play a pivotal role in prognostication, selection of therapy, and response to treatment. 1 13 31 32 33 34 35 36 37…”

Section: Discussionmentioning

confidence: 99%

“…1 Conventional cytogenetics, interphase FISH, RT-PCR find application in the detection of recurrent genetic abnormalities as they play a pivotal role in prognostication, selection of therapy, and response to treatment. 1,13,[31][32][33][34][35][36][37] Translocation t(12;21)(p13;q22), a somatically acquired early lesion, results in the critical TEL/AML1 fusion on chromosome 21, and AML1/ TEL fusion on derivative 12p that can be lost. TEL allele is often deleted the fusion protein acts in a dominant negative fashion inhibiting the normal function of transcription factor AML1.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Study of B Lymphoblastic Leukemia to Assess the Prevalence of TEL/AML1 in South India: A Study of 214 Cases and Review of Literature

Ahmed

Mundada

et al. 2022

Indian J Med Paediatr Oncol

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Introduction Translocation t(12;21)(p13;q22), a recurrent and an invisible chromosomal abnormality, resulting in TEL/AML1 gene fusion, associated with good prognosis, has been described to be a common abnormality, in children with B-acute lymphoblastic leukemia (B-ALL). Objectives The initial observation of very few TEL/AML1 positive patients at this center on testing by fluorescence in situ hybridization (FISH) led to study the prevalence of the abnormality, compare with the global distribution, and evaluate clinical, pathological, molecular, and cytogenetic features in TEL/AML1 positive patients. Materials and Methods A retrospective study of all B-ALL patients tested for TEL/AML1 gene fusion during the period January 2009 to November 2020 was undertaken. Clinicopathological, molecular, cytogenetic, treatment, and follow-up details were collected. All publications dealing with TEL/AML1 gene rearrangement were reviewed post Google and PubMed search. Results TEL/AML1gene rearrangement was assessed by FISH in 178 patients and by reverse transcription polymerase chain reaction in 36 patients and detected as the sole abnormality in 8.4% patients with additional genetic abnormalities noted on FISH evaluation. Normal karyotype was noted in 14/18 (77.7%) of these patients and 2 had complex karyotype. Complete blood count revealed hemoglobin to range from 35 to 116 g/L (median: 74 g/L), white blood count: 1.01–110×109/L (median: 7.8×109/L), platelet counts: 10–115×109/L (median: 42×109/L), blast count in peripheral smear: 0–98% (median: 41%). Immunophenotyping demonstrated 94.4% were CD34 positive, common acute lymphoblastic leukemia associated antigen (CALLA) positive with aberrant expression of CD13, CD33, CD56, singly or in combination in 58.8%. Conclusion TEL/AML1 fusion is rare in Indian patients with B-ALL and appears to be much rarer in our region. The detection of relevant specific abnormalities is of fundamental importance in B-ALL patients and these geographic variations can be used in defining management policies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retrospective Study of B Lymphoblastic Leukemia to Assess the Prevalence of TEL/AML1 in South India: A Study of 214 Cases and Review of Literature

Ahmed

Mundada

et al. 2022

Indian J Med Paediatr Oncol

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“…In the developed world incidence of CNS tumor is quite high, it is the 2 nd commonest tumor [14,15]. In India incidence of CNS tumor is 10-20 Million per year in Bangalore, Chennai, Delhi and Mumbai, Neuroblastoma which is the 2 nd commonest tumor after CNS tumor in pediatric cancer is less frequent in India [17,[37][38][39].…”

Section: Wilms Tumormentioning

confidence: 99%

“…In Chennai Lymphoma shown 20% and CNS tumor shown 11% of all childhood cases[13]. Mortality rate has decreased about 30 per million childhood per year[14,15] 39. 150 per million per year, while in female it is 23-97 per million per year in all PBCR except North Eastern India, Male: Female ratio is much higher than developed part of the world.Male: Female ratio was 2.8:1, median age of representation was 4 years.…”

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confidence: 97%

Common Trend of Childhood Cancer in Eastern India

Devi,

Kumar Singh,

Kumar

et al. 2023

Act Scie Canbio

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Background: Globally 85% of Paediatrics Cancer is reported in developing world. In India nearly 45,000 new paediatrics cancer cases are reported every year which contributed less than 5% of all the cancer cases (1) Riberto 5-year survival rate reported is only 10%, Globally more than 0.2 million cases are diagnosed every year. In developed world 5-year survival rate is quite high about 95%(2) Steller Average incidence of 75 to 150 Paediatrics cancer per million children, Average incidence in India is higher as compared to western population. Material and Method:Our center is the State Cancer Institute, Indira Gandhi Institute of Medical Science, Patna which caters approximately million population of Bihar. All the pediatric patients 0-14-year male registered under HBCR program in Department of Radiation Oncology.Result: Total 1978 childhood cancer was reported in our study. In which 357(68.3%) were male children and 627 (32.48%) where female children 0-19 years age groups common age group was 5 to 19 years 1058(78.31%) cases reported with this age group while 293 cases were reported in 0-4 years in male children which in girl children most cancer age group was 10-19 years in which 358 (57.09%) patients were reported.

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Childhood cancers in Chennai, India, 1990–2001: Incidence and survival

Swaminathan

Ranganathan

Shanta

2008

Intl Journal of Cancer

107

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Childhood cancers (age at diagnosis: 0-14 years) comprise a variety of malignancies, with incidence varying worldwide by age, sex, ethnicity and geography, that provide insights into cancer etiology. A total of 1,334 childhood cancers registered in populationbased cancer registry, Chennai, India, during 1990-2001 and categorized by International Classification of Childhood Cancer norms formed the study material. Cases included for survival analysis were 1,274 (95.5%). Absolute survival was calculated by actuarial method. Cox proportional hazard model was used to elicit the prognostic factors for survival. The age-standardized rates for all childhood cancers together were 127 per million boys and 88 per million girls. A decreasing trend in incidence rates with increasing 5-year age groups was observed in both sexes. The top 5 childhood cancers were the same among boys and girls: leukemias, lymphomas, central nervous system neoplasms, retinoblastomas and renal tumors. The highest 5-year absolute survival was observed in Hodgkin's disease (65%) followed by Wilm's tumor (64%), retinoblastomas (48%), non-Hodgkin's lymphomas (47%), osteosarcomas (44%), acute lymphoid leukemia and astrocytoma (39%). Multifactorial analysis of age at diagnosis and sex showed no differences in the risk of dying for all childhood cancers. Completeness of treatment and type of hospital combination emerged as a prognostic factor for survival for all childhood cancers together (p < 0.001), acute lymphoid leukemia (p < 0.001) and non-Hodgkin's lymphoma (p 5 0.04). A Childhood Cancer Registry with high-resolution data collection is advocated for in-depth analysis of variation in incidence and survival. ' 2008 Wiley-Liss, Inc.Key words: population-based cancer registry; childhood cancer; incidence; survival; childhood cancer registry The network of cancer registries called National Cancer Registry Program of Indian Council of Medical Research, Government of India, has been in existence since 1981. 1 The Madras Metropolitan Tumor Registry (MMTR), a population-based cancer registry (PBCR), based at the Cancer Institute (WIA), Chennai, collects data on all incident cancer cases occurring in Chennai city and publishes reports on incidence and cancer survival to serve as reference material for oncologists involved in clinical work and research. [2][3][4] Childhood cancers (age at diagnosis 0-14 years) comprise a variety of malignancies, with incidence varying worldwide by age, sex, ethnicity and geography, that provide insights into cancer etiology. 5,6 Publications on childhood cancer incidence and, especially, survival are sparse from India. 7,8 This paper analyses the incidence of and survival from childhood malignancies in Chennai during the period 1990-2001. Material and methodsCancer is not a notifiable disease in India. Hence, registration of cases is done by active method. 2 The MMTR covers an entirely urban population (all ages) estimated at 4.1 millions in 1996 in the ratio of 960 females to 1,000 males. The corresponding childhood popula...

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Childhood Cancer Incidence in Delhi, 1996 – 2000

Cited by 7 publications

References 11 publications

Retrospective Study of B Lymphoblastic Leukemia to Assess the Prevalence of TEL/AML1 in South India: A Study of 214 Cases and Review of Literature

Retrospective Study of B Lymphoblastic Leukemia to Assess the Prevalence of TEL/AML1 in South India: A Study of 214 Cases and Review of Literature

Common Trend of Childhood Cancer in Eastern India

Childhood cancers in Chennai, India, 1990–2001: Incidence and survival

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