Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City

Athilat, Shweta; Joe, Cynthia; Rodríguez, Concepción Fernández; Terry, Mary Beth; Tehranifar, Parisa

doi:10.1016/j.annepidem.2018.08.002

Cited by 5 publications

(2 citation statements)

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“…Our findings of strong positive associations between body fatness measures and adipose tissue are consistent with those from previous studies of PMD (13,17,18,(34)(35)(36)(37)(38). Including our previous report from the NHS and NHSII (18), studies have consistently reported that higher levels of body fatness are associated with lower levels of PMD, indicating higher amount of non-dense (adipose) tissue compared with that of dense tissue (epithelial and fibrous stromal tissues combined).…”

Section: Discussionsupporting

confidence: 90%

Early-Life and Adult Adiposity, Adult Height, and Benign Breast Tissue Composition

Yaghjyan

Austin-Datta

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Early-life and adult anthropometrics are associated with breast density and breast cancer risk. However, little is known about whether these factors also influence breast tissue composition beyond what is captured by breast density among women with benign breast disease (BBD).Methods: This analysis included 788 controls from a nested case-control study of breast cancer within the Nurses' Health Study BBD subcohorts. Body fatness at ages 5 and 10 years was recalled using a 9-level pictogram. Weight at age 18, current weight, and height were reported via questionnaires. A deep-learning image analysis was used to quantify the percentages of epithelial, fibrous stromal, and adipose tissue areas within BBD slides. We performed linear mixed models to

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Section: Discussionsupporting

confidence: 90%

Early-Life and Adult Adiposity, Adult Height, and Benign Breast Tissue Composition

Yaghjyan

Austin-Datta

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…A recent systematic review concluded there was a likely association between childhood animal protein intake and earlier puberty assessed by age at menarche and age at peak height velocity (23). Finally the heaviest body size at age 10 as illustrated using the Stunkard images vs. the leanest body sized girls had a 5.9 fold (95% CI: −9.2-2.3) lower percent breast density when they reached ages 40-64 years, with 7.69 cm 2 (95% CI: −13.9-0.63) smaller dense breast area, and 26.17 cm 2 (95% CI: 9.42-43.58) larger non-dense area (24).…”

Section: The First D: Windows Of Exposure Across the Life Course (Figmentioning

confidence: 97%

Breast Cancer and Nutrition: A Paradigm for Prevention in 3D Across the Life Course

Forman

2020

Front. Oncol.

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Breast cancer, the most common cancer in women worldwide, has recognized reproductive and anthropometric risk factors including age at menarche and adult height. Yet the age when a woman attains her adult height or experiences menarche for example is simply the timing of the major life event at the end of a long trail of exposures that began in utero. The objective of this article is to investigate through a review of the literature the role of nutrition in breast cancer prevention through three dimensions (D). Each D offers a different lens. The First D identifies windows/ages of exposures or conditions that convey vulnerability or protection from breast cancer. The Second D addresses the intensity and duration of the exposure; and the (Third D) examines the pace, i.e., how rapid or slow the young woman experiences her growth and development. Birthweight illustrative of the First D reveals a strong signal across the life course on BC risk, but the risk group varies from low to high birthweight. Stressful life events like being a pubertal aged girl living in a household with an unemployed father during the Great Depression or high levels of environmental contaminants exposure are representative of the Second D. Height velocity at specific ages and weight loss in postmenopausal years are illustrative of anthropometric trajectories that reveal an adaptive biosystem that provides a contextual state to interact with the other two Ds. This article presents a new paradigm of nutrition and breast cancer prevention through the lens of three very different dimensions. It is the premise of this article that all three dimensions are essential tasks to tease apart the life course and identify windows for preventive strategies.Breast cancer is the most common cancer in women across the world (1). A family history of breast cancer (BC), high breast density, reproductive risk factors including early age at menarche, late age at menopause, older age at first birth, and nulliparity, as well as being tall, moderate to high alcohol consumption, being physically inactive and menopausal status specific-body mass index are a constellation of recognized risk factors influencing BC risk (2, 3). Yet the age when a woman attains her adult height or experiences menarche for example is simply the timing of the major life event at the end of a long trail of exposures that began in utero. The tempo of height velocity and the peak height velocity that end in a woman's adult height, and the age of first birth and pace of occurrence (i.e., time interval between first and last births) are essential components to understanding the cumulative risk from adult height and parity on BC risk (4). Indeed profiling a woman's linear growth trajectory from birth across her life course may likely be key to identifying and understanding strategies for BC prevention.

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In utero and postnatal programing of dehydroepiandrosterone sulfate (DHEAS) in young adult women

Cohn

Cirillo

2020

Reproductive Toxicology

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Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City

Abstract: Heavy childhood body size is associated with lower mammographic density, consistent with its associations with breast cancer risk. Suggestive findings by nativity require confirmation in larger samples.

Cited by 5 publications

References 48 publications

Early-Life and Adult Adiposity, Adult Height, and Benign Breast Tissue Composition

Early-Life and Adult Adiposity, Adult Height, and Benign Breast Tissue Composition

Breast Cancer and Nutrition: A Paradigm for Prevention in 3D Across the Life Course

In utero and postnatal programing of dehydroepiandrosterone sulfate (DHEAS) in young adult women

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