Childhood Attention Deficit/Hyperactivity Disorder and Alcohol Dependence: A 1-Year Follow-Up

Ercan, Eyüp Sabri; Çoşkunol, Hakan; Varan, Azmi; Toksöz, Kaan

doi:10.1093/alcalc/agg084

Cited by 72 publications

(61 citation statements)

References 19 publications

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“…Even though some studies have shown that ADHD severity might worsen SUD prognosis (10,11), it is possible to speculate that ADHD improvement within a short period of time (3 weeks) is not enough to decrease drug use in adolescents with chronic use. In this respect, Riggs et al (17) also found no drug use improvement despite ADHD improvement.…”

Section: Discussionmentioning

confidence: 99%

“…The comorbidity is clinically relevant, since ADHD is associated with both earlier and more frequent alcohol relapses (10) and a lower likelihood of cannabis treatment completion (11) in adolescents. Several evidence-based guidelines have suggested that stimulants such as methylphenidate (MPH) should be the first option for treatment of ADHD (see, for instance, Pliszka et al,12).…”

Section: Introductionmentioning

confidence: 99%

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A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder

Szobot

Rohde

Katz

et al. 2008

Braz J Med Biol Res

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Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attentiondeficit/hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, singleblind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression Scale (CGI). We also evaluated the adverse effects of MPH-SODAS using the Barkley Side Effect Rating Scale and subject reports of drug use during the study. The sample consisted of marijuana (N = 16; 100%) and cocaine users (N = 7; 43.8%). Subjects had a significantly greater reduction in SNAP-IV and CGI scores (P < 0.001 for all analyses) during MPH-SODAS treatment compared to placebo. No significant effects for period or sequence were found in analyses with the SNAP-IV and CGI scales. There was no significant effect on drug use. MPH-SODAS was well tolerated but was associated with more severe appetite reduction than placebo (P < 0.001). MPH-SODAS was more effective than placebo in reducing ADHD symptoms in a non-abstinent outpatient sample of adolescents with comorbid SUD. Randomized clinical trials, with larger samples and SUD intervention, are recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder

Szobot

Rohde

Katz

et al. 2008

Braz J Med Biol Res

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“…In another two studies, it has also been reported that alcohol dependent patients who have a comorbid ADHD are characterized by early initiation of addiction (Ercan, Coskunol, Varan, & Toksoz, 2003;Sartor, Lynskey, Heath, Jacob, & True, 2007;Sringeri, Rajkumar, Muralidharan, Chandrashekar, & Benegal, 2008). This would affect treatment, since early initiation has been associated with more severe addiction, family history, behavioural problems in childhood, greater craving, hostility, antisocial personality traits, mood disorders and poorer social adjustment than patients who develop dependence later (Sringeri, Rajkumar, Muralidharan, Chandrashekar, & Benegal, 2008).…”

Section: Adhd and Depressant Substance Usementioning

confidence: 98%

“…Respecto a la evolución en el tratamiento, se ha descrito que pacientes dependientes de alcohol que también presentaban TDAH recaían una media de 2.7 meses antes que los pacientes sin este trastorno (Ercan, et al, 2003;Grella, Hser, Joshi y Rounds-Bryant, 2001) (Tabla 1).…”

Section: Adhd and Depressant Substance Useunclassified

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Trastorno por déficit de atención con hiperactividad y dependencia de sustancias depresoras. Una revisión

et al. 2013

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Resumen AbstractThe comorbidity between attention deficit hyperactivity disorder (ADHD) and substance use disorders is very common. A review of literature addressing prevalence, clinical features and treatment of the comorbidity between ADHD and CNS depressants was conducted. The prevalences found have a wide range (4.5% to 58%). ADHD has been associated with greater severity of addiction, early onset of consumption and addiction, more psychiatric comorbidity and more chronicity. In drug-dependent patients the diagnosis is a complex process because the frequent overlap of symptoms. The screening instruments should be used with caution.Drug therapy has shown efficacy in reducing ADHD symptoms, but there is no consensus regarding their influence on substance use.However, results should be interpreted cautiously, because the samples are small. Psychoeducational interventions are relevant, but treatment outcomes have not been described or studied systematically.Key Words: ADHD, addictions, alcohol, cannabis, opioids.Existe una elevada comorbilidad entre el trastorno por déficit de atención con hiperactividad (TDAH) y los trastornos por uso de sustancias. Se revisa la literatura sobre la prevalencia, características clínicas y tratamiento de la comorbilidad del TDAH con la dependencia de sustancias depresoras del SNC. Las prevalencias encontradas presentan amplia variabilidad (4,5% a 58%). El TDAH se asocia a una mayor gravedad de la adicción, menor edad de inicio del consumo y de la adicción, mayor presencia de otros trastornos psicopatológicos y mayor cronicidad. En pacientes drogodependientes el diagnóstico es un proceso complejo por el frecuente solapamiento de síntomas. Los instrumentos de cribado se deben utilizar con precaución.El tratamiento farmacológico ha mostrado eficacia en la reducción de los síntomas del TDAH y no hay consenso respecto a su influencia sobre el consumo. Sin embargo, los resultados se deben interpretar con cautela, porque las muestras son pequeñas. Las intervenciones psicoeducativas son relevantes, pero no se han descrito, ni estudiado sistemáticamente los resultados de este tipo de intervenciones.

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Children with ADHD Grown Up

Antshel¹,

Barkley

2011

Learning and Attention Disorders in Adolescence and Adulthood

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Childhood Attention Deficit/Hyperactivity Disorder and Alcohol Dependence: A 1-Year Follow-Up

Abstract: As found in other countries, alcohol dependence in Turkish subjects with childhood ADHD starts early and is relatively resistant to treatment. Early diagnosis and treatment of ADHD might help prevent alcohol- and substance-related disorders.

Cited by 72 publications

References 19 publications

A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder

A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder

Trastorno por déficit de atención con hiperactividad y dependencia de sustancias depresoras. Una revisión

Children with ADHD Grown Up

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