Childhood Asthma Management and Environmental Triggers

Hollenbach, Jessica P.; Cloutier, Michelle M.

doi:10.1016/j.pcl.2015.05.011

Cited by 17 publications

(9 citation statements)

References 98 publications

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“…Asthma is the commonest chronic disease among children, and industrialized countries experience high lifetime asthma prevalence that has increased over recent decades [ 9 ]. The diagnosis for asthma is usually obvious clinically, although this is occasionally confused with other conditions, most notably with airway obstruction from other pathology.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Foreign Body Presenting as Exacerbation of Asthma

Tsang

Sun

Ooi

et al. 2017

Case Reports in Emergency Medicine

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Airway foreign bodies are a leading cause of death among children and require urgent recognition by medical personnel. While most cases are diagnosed readily from a clinical history of acute respiratory distress, some cases remain more indolent and present later. We report the case of a 7-year-old boy who aspirated a “LEGO” toy and presented with a week history of increasing respiratory distress compatible with known asthma. Despite a normal chest X-ray, a low-dose computed tomography showed the presence of a foreign body in the left main bronchus, which was subsequently removed by fiberoptic bronchoscopy. Our case serves to reemphasize the importance of considering airway foreign bodies as a cause of respiratory distress, especially in young children.

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Section: Discussionmentioning

confidence: 99%

Endobronchial Foreign Body Presenting as Exacerbation of Asthma

Tsang

Sun

Ooi

et al. 2017

Case Reports in Emergency Medicine

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“…The global mortality rate for childhood asthma ranges 0 to 0.7 per 100,000 population. [ 4 – 6 ] Lifetime prevalence reaches 14% in children. Asthma affects seriously childhood health and imposes extremely high medical costs on families and society.…”

Section: Introductionmentioning

confidence: 99%

“…[ 9 ] GWASs have identified several regions associated with asthma. [ 6 ] In recent years, the exploration of genetic susceptibility to asthma has become an important subject worldwide. However, some results remain largely inconsistent, even contradictory.…”

Section: Introductionmentioning

confidence: 99%

Asthma susceptible genes in children

et al. 2020

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“…About 14.2% of children worldwide experienced asthma symptoms. The global mortality rate for childhood asthma ranges 0 to 0.7 per 100,000 population [4][5][6] . Lifetime prevalence reaches 14% in children.…”

Section: Introductionmentioning

confidence: 99%

“…Genes play a greater role in pediatric asthma than adults, a genome-wide association study (GWAS) found that the genes associated with childhood asthma are almost three times that of adults 9 . GWASs have identi ed several regions associated with asthma 6 . In recent years, the exploration of genetic susceptibility to asthma has become an important subject worldwide.…”

Section: Introductionmentioning

confidence: 99%

Asthma susceptible genes in children: A meta-analysis

Ruan

Shi

Zhang

et al. 2020

Preprint

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Background: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appeared conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. Methods: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to access the strength of the associations. Results: 45 case-control studies were finally included in this meta-analysis. Eighteen SNPs were identified. Ten polymorphisms were found to be associated with asthma risk: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ, VDR BsmⅠ. After subgroup analysis, IL-13 +2044G/A, ADAM33 T2, ADAM33 T1, VDR ApaⅠ, VDR BsmⅠ polymorphisms were associated with increased risk of asthma among Asian populations. IL-4 -590C/T polymorphisms may be related to asthma risk in Chinese children.Conclusions: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ and VDR BsmⅠ polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate the associations.

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Childhood Asthma Management and Environmental Triggers

Cited by 17 publications

References 98 publications

Endobronchial Foreign Body Presenting as Exacerbation of Asthma

Endobronchial Foreign Body Presenting as Exacerbation of Asthma

Asthma susceptible genes in children

Asthma susceptible genes in children: A meta-analysis

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