Backgrounds: When facing the new growth field of university, some college students will quickly form good university adaptation, while others will have maladaptation behavior. The students’ adaptations of to the growth environment in universities and smooth transition to adulthood are the important topics in recent years. Methods:Present study introduces irrational beliefs to investigate the effects of parenting mode on maladaptation of university students. The questionnaires based on simplified parenting mode (Chinese), irrational belief and adaptability were administered in a survey of 510 university students in Zhanjiang on October, 2021, by using the random sampling method. Parenting mode was used as the independent variable, while the emotionally warm, overprotective and rejecting types were used as the indices. Further, the irrational beliefs including summary comments, awful beliefs and low tolerance to setbacks as well as maladaptation were included in the mediation model for analysis.Results: The results showed that emotionally warm parenting mode was negatively correlated with summary comments (r = -0.334), awful beliefs (r = -0.108) and low tolerance to setbacks (r = -0.153). The rejection parenting mode was negatively related with absolute requirements (r = -0.143), and learning motivation (r = -0.157), interpersonal adaptation (r = -0.283) and physical and psychological adjustment(r=-0.083). Overprotection was negatively correlated with absolute requirements (r = -0.042) and interpersonal adaptation (r = -0.042). The mediating effect of irrational beliefs (low tolerance to setbacks, awful beliefs and absolute requirements), the lower and upper limits of Bootstrap confidence interval were 0.141 and 0.532, respectively, excluding 0, which indicated that the mediating effect is true. Conclusion: Through the analysis of the data, this study believes that irrational beliefs such as low tolerance to setbacks, awful beliefs and absolute requirements mediate the effects on school adjustment. Parenting mode can influence adaptability of university students. Emotionally warm parents strengthen the adaptability of university students. By contrast, negative parenting modes such as overprotection and rejection inculcate irrational beliefs, resulting in maladaptation of university students.