Childhood and adolescent obesity and long‐term cognitive consequences during aging

Wang, Jun; Freire, Daniel; Knable, Lindsay; Wang, Zhao; Gong, Bing; Mazzola, Paolo; Ho, Lap; Levine, Samara; Pasinetti, Giulio Maria

doi:10.1002/cne.23799

Cited by 11 publications

(19 citation statements)

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“…However, in these studies, animals were maintained on an HFD for a longer period and displayed more severe metabolic changes, as measured by elevated fasting blood glucose levels . Otherwise, they were subjected to behavioral testing in their old age . In contrast, male mice in our model were fed an HFD for only 10 weeks, and they exhibited an increased body weight while maintaining normal fasting glucose levels.…”

Section: Discussionmentioning

confidence: 98%

“…It should be noted that our results showed that 10 weeks of HFD exposure was insufficient to impair hippocampus‐dependent learning and memory in F0 fathers. Previous animal studies have reported that diet‐induced obesity exerts negative effects on cognitive function . However, in these studies, animals were maintained on an HFD for a longer period and displayed more severe metabolic changes, as measured by elevated fasting blood glucose levels .…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is increasingly considered a risk factor for cognitive dysfunction. Human epidemiologic and animal studies have demonstrated that diet‐induced obesity negatively affects cognitive functions . Moreover, it has been demonstrated that diet‐induced maternal obesity impairs hippocampal neurogenesis and spatial learning performance in mice offspring because of decreased hippocampal brain‐derived neurotrophic factor (BDNF) production .…”

Section: Introductionmentioning

confidence: 99%

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Diet‐Induced Paternal Obesity Impairs Cognitive Function in Offspring by Mediating Epigenetic Modifications in Spermatozoa

Zhou

Zhu

et al. 2018

Obesity

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Objective This study aimed to determine the effects of diet‐induced paternal obesity on cognitive function in mice offspring. Methods Male mice (F0) were randomized to receive either a control diet (10 kcal% fat) or a high‐fat diet (HFD; 60 kcal% fat) for 10 weeks before being mated with normal females to generate F1 offspring. Male F1 offspring were mated with normal females to generate F2 offspring. Behavioral tests were used to assess cognitive functions in F1 and F2 offspring. Reduced representation bisulfite sequencing was used to the explore mechanisms of epigenetic inheritance. Results HFD‐induced paternal obesity resulted in cognitive impairments in F1 offspring, potentially due, at least in part, to increased methylation of the BDNF gene promoter, which was inherited from F0 spermatozoa. BDNF/tyrosine receptor kinase B signaling was associated with cognitive impairments in HFD‐fed F1 offspring. However, there were no significant changes in F2 offspring. Conclusions The findings provide evidence of intergenerational effects of paternal obesity on cognitive function in offspring occurring via epigenetic spermatozoan modifications.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diet‐Induced Paternal Obesity Impairs Cognitive Function in Offspring by Mediating Epigenetic Modifications in Spermatozoa

Zhou

Zhu

et al. 2018

Obesity

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“…It has been anticipated that LTF might be the main factor that permits the normal growth of the newborn CNS; in its absence, the newborn's immune system would be stimulated to the point of making CNS shrink for glucose starvation [47]. The recent determination of cognitive impairment in obese children (obesity is now deemed a pro-inflammatory condition) speaks in favour of the above statements [48].…”

Section: B)mentioning

confidence: 99%

Inflammation: a highly conserved, Janus-like phenomenon—a gastroenterologist’ perspective

2018

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Inflammation is the result of the loss of host's resilience towards the surrounding world. At gross tissue level, inflammation coincides with fluid leakage from vessels, swelling, and blood stasis and extravasation of mononuclear/macrophage cells. Biochemically, these events lead to anoxia and dramatic changes: interruption of the mitochondrial oxidative phosphorylation, influx of the M1 macrophage subset, which live on anaerobic glycolysis. Fall of ATP then leads to energy shortage and debt. In their chronic forms, these phenomena are now known to mark a number of degenerative disorders that have invaded the Western World since the last century: Parkinson's disease, Alzheimer's syndromes, rheumatic diseases, metabolic diseases. Intriguingly, these affections seem to derive from the gut, along two possible pathways. A sort of ascending loss of function caused by accumulation of (and hyperreactivity to) proteins released to restrain spread of enteric viruses: the alpha-synucleins, now increasingly spotted in relation to Parkinson's pathogenesis. The second pathway would entail the intellectual decline perhaps brought about by large use of food containing the proteins of red processed meat. The bacterium Bilophila wadsworthia, thriving in this meat, can erode the mucus layer on colon surfaces, allowing further bacterial flora to approach lining cells, so upgrading the alarm state. We discuss two strategies to prevent such instability from ending up to full-blown inflammatory bowel disease: physical exercise and systematic switch to fibre-containing diets.

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“…Obesity is a factor considerably reducing the quality of human life. It leads to numerous psychophysical complications [4,5]. It is recognized as a sociocultural problem this also concerns the Polish society.…”

Section: Introductionmentioning

confidence: 99%

Effect of the depletion of self-control strength on the self-regulation of the nutritional process in obese individuals

Obara-Gołębiowska¹,

Brycz²

2017

Balt J Health Phys Act

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Childhood and adolescent obesity and long‐term cognitive consequences during aging

Cited by 11 publications

References 0 publications

Diet‐Induced Paternal Obesity Impairs Cognitive Function in Offspring by Mediating Epigenetic Modifications in Spermatozoa

Diet‐Induced Paternal Obesity Impairs Cognitive Function in Offspring by Mediating Epigenetic Modifications in Spermatozoa

Inflammation: a highly conserved, Janus-like phenomenon—a gastroenterologist’ perspective

Effect of the depletion of self-control strength on the self-regulation of the nutritional process in obese individuals

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