Childhood adversity, poly-substance use, and disordered eating in adolescent Latinas: Mediated and indirect paths in a community sample

Hodson, Christopher; Newcomb, Michael D.; Locke, Thomas F.; Goodyear, Rodney K.

doi:10.1016/j.chiabu.2005.10.017

Cited by 25 publications

(19 citation statements)

References 49 publications

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“…Adverse childhood experiences have been associated with mood disorders [1], schizophrenia [2], [3], [4], anxiety disorders [5], suicide [6], personality disorders [7], [8], posttraumatic stress disorder [9], [10], and substance use disorders [11], [12], [13], [14]. Excessive and persistent adversity in early childhood produces sustained elevations of stress hormones (e.g., cortisol) [15], which may damage the development of the basic neural circuitry in the brain.…”

Section: Introductionmentioning

confidence: 99%

“…An additional and pressing concern is that CA-associated methylation changes may be confounded by comorbid disorders. For example, there is evidence that CA is associated with abuse of or dependence on multiple substances [11], [12], [13], [14]. We recently observed DNA methylation alterations in specific genes in patients with alcohol dependence (AD) by examining methylation levels of 384 CpGs in 82 candidate genes using the Illumina GoldenGate methylation array [27].…”

Section: Introductionmentioning

confidence: 99%

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Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls

et al. 2013

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The increased vulnerability to alcohol dependence (AD) seen in individuals with childhood adversity (CA) may result in part from CA-induced epigenetic changes. To examine CA-associated DNA methylation changes in AD patients, we examined peripheral blood DNA methylation levels of 384 CpGs in promoter regions of 82 candidate genes in 279 African Americans [AAs; 88 with CA (70.5% with AD) and 191 without CA (38.2% with AD)] and 239 European Americans [EAs; 61 with CA (86.9% with AD) and 178 without CA (46.6% with AD)] using Illumina GoldenGate Methylation Array assays. The effect of CA on methylation of individual CpGs and overall methylation in promoter regions of genes was evaluated using a linear regression analysis (with consideration of sex, age, and ancestry proportion of subjects) and a principal components-based analysis, respectively. In EAs, hypermethylation of 10 CpGs in seven genes (ALDH1A1, CART, CHRNA5, HTR1B, OPRL1, PENK, and RGS19) were cross validated in AD patients and healthy controls who were exposed to CA. P values of two CpGs survived Bonferroni correction when all EA samples were analyzed together to increase statistical power [CHRNA5_cg17108064: Padjust = 2.54×10−5; HTR1B_cg06031989: Padjust = 8.98×10−5]. Moreover, overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) were elevated in both EA case and control subjects who were exposed to CA. However, in AAs, CA-associated DNA methylation changes in AD patients were not validated in healthy controls. Our findings suggest that CA could induce population-specific methylation alterations in the promoter regions of specific genes, thus leading to changes in gene transcription and an increased risk for AD and other disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls

et al. 2013

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“…Several findings show that drug dependence and anorexia nervosa share common processes regarding loss of control and repetitive and compulsive actions (Davis, Katzman, & Kirsh, ; Speranza et al, ). If anorexia nervosa and drug dependence are different forms of a common, underlying addictive process, there should be a shared etiology concerning family functioning (Doba & Nandrino, ; Hodson, Newcomb, Locke, & Goodyear, ). Although studies show that anorexia nervosa and drug dependence disorder display numerous psychopathologic similarities, knowledge about their mutually predisposing factors or shared family profiles is scarce.…”

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confidence: 99%

“…Anorexia nervosa is associated with a more rigid family climate (e.g., family taboos regarding nudity and sexuality) during childhood as compared with drug dependence disorder. Some researchers have observed that sexual or physical abuse predicted anorexia nervosa and drug dependence, and these associations are mediated by impaired, insecure parental bonding (Hodson et al, ; Mangweth et al, ).…”

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confidence: 99%

Is There a Family Profile of Addictive Behaviors? Family Functioning in Anorexia Nervosa and Drug Dependence Disorder

Doba

Nandrino

Dodin³

et al. 2013

J Clin Psychol

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“…Maltreatment during childhood is associated with a number of behavioral problems during adolescence and adulthood ranging from unplanned pregnancy (Rodgers et al, 2004) and substance use (Hodson, Newcomb, Locke, & Goodyear, 2006) among adolescents to gambling (Petry & Steinberg, 2005), alcoholism (Rodgers et al, 2004), and drug use (Spatz Widom, Marmorstein, & Raskin White, 2006) among adults. More specifically, Hodson et al found that in a community sample of Latina adolescents, physical and emotional abuse predicted poly-substance use (cigarette, alcohol, cannabis, and hard drugs).…”

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confidence: 99%

Childhood Maltreatment Among Community Dwelling Adult Latinas

Bowman

Rew

Murphey

2009

Issues in Mental Health Nursing

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There is a lack of research about childhood maltreatment among adult Latinas in the United States. The aim of this secondary analysis was to explore the occurrence and co-occurrence of maltreatment during childhood in a community-dwelling sample of adult Latinas. Participants were 62 women ages 18-45 who read and spoke English, attended work or school on a regular basis, and had no health or functional interferences with daily living. On average, participants were 29 years of age (M = 29.08, SD = 9.30), high school graduates (n = 36, 58.1%), married (n = 36, 58.1%), and employed (n = 27, 43.5%). Over three quarters of participants (n = 49, 79.0%) reported at least one form of childhood maltreatment: emotional abuse (n = 24, 38.7%), physical abuse (n = 29, 46.8%), sexual abuse (n = 29, 46.8%), emotional neglect (n = 27, 43.5%), and physical neglect (n = 23, 37.1%). Maltreatment severity increased with the number of maltreatment forms. Women sexually abused during childhood were more likely than women without this history to be employed and high school graduates. These Latinas may have developed more adaptive coping mechanisms than other Latinas.

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Childhood adversity, poly-substance use, and disordered eating in adolescent Latinas: Mediated and indirect paths in a community sample

Cited by 25 publications

References 49 publications

Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls

Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls

Is There a Family Profile of Addictive Behaviors? Family Functioning in Anorexia Nervosa and Drug Dependence Disorder

Childhood Maltreatment Among Community Dwelling Adult Latinas

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