Childhood acute myelogenous leukaemia: Association between PRAME, apoptosis- and MDR-related gene expression

Goellner, Stefanie; Steinbach, Daniel; Schenk, Tino; Gruhn, Bernd; Zintl, F; Ramsay, Edward; Saluz, Hans Peter

doi:10.1016/j.ejca.2006.06.018

Cited by 23 publications

(18 citation statements)

References 26 publications

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“…While in cell-based models PRAME was reported to down-regulate genes such as S100A4, RARβ2, p21 and Hsp27 [47], a clinical study reported that expression levels of these genes were not significantly associated with PRAME expression in paediatric AMLs [52]. A focussed microarray study of childhood AMLs examining the expression of 300 stress-related genes reported a correlation between PRAME expression with up-regulation of multidrug resistance genes (MRP3 and BCRP) and down-regulation of pro-apoptotic genes (CIAP2, AKT3, BAK1, BAX) [53]. However the same genes were unaffected when PRAME was over-expressed or silenced in cervical cancer cell lines [52].…”

Section: Cellular Functions Of Prame: Repression Of Retinoic Acid Recmentioning

confidence: 99%

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

et al. 2010

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PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.

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Section: Cellular Functions Of Prame: Repression Of Retinoic Acid Recmentioning

confidence: 99%

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

et al. 2010

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“…37 Insights into the function of leukaemia-associated antigens were recently gained from investigating the biology of PRAME (preferentially expressed antigen of melanoma) in pediatric AML showing PRAME-positive cases to harbor an increased expression of genes encoding ABC transporters, such as multidrug resistance proteins and decreased expression of genes encoding apoptotic proteins. 38 And recently like in adult AML, 24 co-clustering of CEBPA-mutated AML with CEBPA wildtype samples identified promoter hypermethylation-based CEB-PA silenced cases. 31 Thus, in both adult and pediatric AML, GEP studies have proven to be of value for class prediction, class discovery, outcome prediction and the identification of novel biological insights.…”

Section: Gep In Pediatric Amlmentioning

confidence: 99%

Gene expression profiling in MDS and AML: potential and future avenues

et al. 2011

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“…PRAME family of gene is germinal tissue-specific that is also expressed at high levels in hematological malignancies and solid tumors, but the physiological functions of PRAME in normal and tumor cells are unknown. 15 LARP6 and TET2 are not well described but seem to be involved in the regulation of gene expression. TET2 mutations were recently described in myeloid and lymphoid malignancies.…”

Section: Discussionmentioning

confidence: 99%

Identification of genes regulating TRAIL-induced apoptosis in rheumatoid arthritis fibroblasts-like synoviocytes

et al. 2015

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We previously described that sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis varied in rheumatoid arthritis fibroblasts-like synoviocytes (RAFLS) from one patient to another and was correlated with disease severity. Therefore, we screened for genes differentially expressed in RAFLS sensitive and resistant to TRAIL-induced apoptosis. The sensitivity of RAFLS was defined based on the percentage of TRAIL-induced apoptosis: 0-10% for resistant cells and >25% for sensitive RAFLS. We performed transcriptomic comparison between RAFLS-S (n=6) and RAFLS-R (n=6) and then examined the implication of identified candidates in the regulation of apoptosis using small interference RNA (siRNA). Microarray analysis revealed 10 functional genes differentially expressed according to TRAIL sensitivity. These factors are implicated in different functions, such as the respiratory chain (ND3), the transport of lipids (OSBP2, PLTP), the regulation of signaling linked to extracellular factors (SULF2, GALNT1, SIAE) or the regulation of gene expression (TET2 and LARP6). We confirmed differential expression for GALNT1 and LARP6 by quantitative reverse transcriptase-PCR. Using siRNA extinction, we demonstrated the implication of GALNT1, SULF2 and LARP6 in the control of TRAIL-induced responses. These results are of particular interest as GALNT1 and LARP6 have been implicated in the regulation of cell death and may represent interesting targets to induce apoptosis of RAFLS.

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Childhood acute myelogenous leukaemia: Association between PRAME, apoptosis- and MDR-related gene expression

Cited by 23 publications

References 26 publications

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Gene expression profiling in MDS and AML: potential and future avenues

Identification of genes regulating TRAIL-induced apoptosis in rheumatoid arthritis fibroblasts-like synoviocytes

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