Childhood actinic keratosis in an albino transforming into squamous cell carcinoma

Agale, Shubhangi Vinayak; D'Costa, Grace; Bharambe, Bhavana M; Bhatia, Varsha

doi:10.4103/2229-5178.101820

Cited by 4 publications

(4 citation statements)

References 8 publications

(19 reference statements)

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“…To respond to this conflict, the rate of development of SCC from AK is almost 0.025 to 16%. ( 19 ). In addition, there is no correlation between AK and BCC.…”

Section: Discussionmentioning

confidence: 99%

Common malignant cutaneous conditions among albinos in Kenya

Emadi

Suleh

Babamahmoodi

et al. 2017

Med J Islam Repub Iran

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Background: Albinos in Africa are at constant risk of developing skin cancer due to the damage caused by ultra-violet exposure. This study identifies the common skin conditions among albinos in Kenya as a country located along the equator. Methods: In this descriptive study on albino patients who were admitted to Mbagathi District Hospital in Nairobi, Kenya the census method was used for sampling and a total of 151 albinos were registered. All necessary data including age, gender, type, site and the number of skin lesions were recorded. Suspected patients with malignant and premalignant lesions were studied individually through skin biopsy and histopathological investigation. Finally, the collected data were analyzed using SPSS software. Results: Albinos with serious skin lesions were 121(80%) patients. Females were 64 (52.9%). The frequency of the following premalignant and malignant skin lesions including actinic-cheilitis, solar elastosis, actinic keratosis (AK), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) were 17.88%, 11.92%, 37.08%, 7.94% and 5.29%, respectively. Hands (20.52%), face (19.20%), head (18.18%), shoulder (14.56%) and neck (7.94%) were the most affected areas by malignant and premalignant lesions. Conclusions: BCC was the most common type of cutaneous malignancy on the face and shoulders while AK was the most common cutaneous pre-malignancy on the hands and face in albinos in Kenya. Therefore, appropriate physical protection, avoiding any trauma when carrying sharp, heavy or rough instruments by the shoulder and hands, and finally urgent and quality treatment for any lesion even a small erosion and ulcer, especially on exposed areas in albinos, are recommended.

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“…To respond to this conflict, the rate of development of SCC from AK is almost 0.025 to 16%. ( 19 ). In addition, there is no correlation between AK and BCC.…”

Section: Discussionmentioning

confidence: 99%

Common malignant cutaneous conditions among albinos in Kenya

Emadi

Suleh

Babamahmoodi

et al. 2017

Med J Islam Repub Iran

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“…Actinic keratoses have historically been considered as a precancerous condition with potential for developing into squamous cell carcinoma. [1] Albinos commonly develop squamous cell carcinoma. [23] Other less frequently encountered malignancies are basal cell carcinoma, dysplastic nevus, and melanoma.…”

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confidence: 99%

Multiple basal cell carcinomas in a patient of oculocutaneous albinism

Behera

Tripathy

Kar

2017

Indian Dermatol Online J

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“…As mentioned above, the prevalence of actinic keratoses increases according to the age of the patients, ranging from <10% in Caucasians aged 20–29 years, to 80% in individuals aged 60–69 years 27 . Exceptions occur in albinos and patients carrying other genodermatoses that present defects in DNA repair genes, such as xeroderma pigmentosum, Rothmund–Thompson syndrome, Cockayne's syndrome, and Bloom's syndrome, which may present lesions in the first decade of life, and lesions with greater aggressiveness and risk 1, 28, 29, 30. Age is an independent risk factor for the development of actinic keratoses, with odds ratios (OR) ranging from 1.6 to 41.5 according to age; the OR is of 4.8 for individuals between 46 and 60 years and up to 41.5 years in individuals over 70 31, 32, 33, 34…”

Section: Epidemiologymentioning

confidence: 99%

Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects

Reinehr

Bakos

2019

Anais Brasileiros de Dermatologia

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Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic plaques with an erythematous background that occur on photoexposed areas. At initial stages, they may be better identified by palpation rather than by visual inspection. They may also be pigmented and show variable degrees of infiltration; when multiple they then constitute the so-called field cancerization. Their prevalence ranges from 11% to 60% in Caucasian individuals above 40 years. Ultraviolet radiation is the main factor involved in pathogenesis, but individual factors also play a role in the predisposing to lesions appearance. Diagnosis of lesions is based on clinical and dermoscopic examination, but in some situations histopathological analysis may be necessary. The risk of transformation into squamous cell carcinoma is the major concern regarding actinic keratoses. Therapeutic modalities for actinic keratoses include topical medications, and ablative and surgical methods; the best treatment option should always be individualized according to the patient.

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Childhood actinic keratosis in an albino transforming into squamous cell carcinoma

Cited by 4 publications

References 8 publications

Common malignant cutaneous conditions among albinos in Kenya

Common malignant cutaneous conditions among albinos in Kenya

Multiple basal cell carcinomas in a patient of oculocutaneous albinism

Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects

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