Childhood abuse, the BDNF-Val66Met polymorphism and adult
                        psychotic-like experiences

Alemany, Silvia; Arias, Bárbara; Aguilera, Mari; Villa, Helena; Moya, Jorge; Ibáñez, Manuel I.; Vossen, Helen; Gastó, Cristòbal; Ortet, Generós; Fañanás, Lourdes

doi:10.1192/bjp.bp.110.083808

Cited by 112 publications

(121 citation statements)

References 39 publications

(77 reference statements)

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“…Firstly, the present twin sample from the general population showed similar means and prevalences of psychotic experiences to those reported previously in singleton samples also using the CAPE questionnaire (3,15). In respect to childhood adversity, in a large communitybased study using the original version of the ACE questionnaire 36.1% of the sample reported 0 adverse childhood experiences, 26.0% reported one adverse childhood experience and the rest reported two or more adverse childhood experiences (38).…”

Section: Discussionsupporting

confidence: 84%

“…These mechanisms of geneenvironment interplay may underlie previously reported associations between environmental risk factors such as childhood adversity and psychotic outcomes. Indeed, two recent studies provide evidence for gene-environment interaction effects in the association between psychosocial stress factors and psychotic experiences in samples drawn from the general population (15)(16). However, it would be also important to clarify whether environmental factors per se have an impact on the expression of psychosis.…”

Section: Introductionmentioning

confidence: 99%

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Childhood adversity and psychosis: Examining whether the association is due to genetic confounding using a monozygotic twin differences approach

et al. 2012

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140 Word count of text: 4279Number of tables/figures: 2 3 Abstract Purpose: To test whether the association between childhood adversity and positive and negative psychotic experiences is due to genetic confounding. Method:Childhood adversity and psychotic experiences were assessed in a sample of 226 twins from the general population. A monozygotic (MZ) twin differences approach was used to assess possible genetic confounding. Results:In the whole sample, childhood adversity was significantly associated with positive (β =.45; SE=.16; p=.008) and negative psychotic experiences (β=.77; SE=.18; p<.01). Within-pair MZ twin differences in exposure to childhood adversity were significantly associated with differences in positive (β =.71; SE=.29; p=.016) and negative psychotic experiences (β =.98; SE=.38; p=.014) in a subsample of 86 MZ twin pairs.Conclusions: Individuals exposed to childhood adversity are more likely to report psychotic experiences. Furthermore, our findings indicate that unique environmental effects of childhood adversity contribute to the development of psychotic experiences.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Childhood adversity and psychosis: Examining whether the association is due to genetic confounding using a monozygotic twin differences approach

et al. 2012

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“…With respect to the main aim of the present study, the prevalence of individuals exposed to childhood abuse among the FEP patients (52%) was similar to that reported for childhood physical abuse by Üçok and colleagues (40.9%) (10) which is higher than the prevalences reported for childhood adversity in non clinical samples (25% 32%) (34). The fact that individuals at psychometric risk for psychosis (High CAPE group) also presented a high prevalence of childhood abuse is in accordance with previous research, although others have found even higher prevalences (35).…”

Section: Discussionsupporting

confidence: 87%

Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences

et al. 2015

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2 AbstractPurpose: The present study aimed to extend the literature on childhood trauma and psychosis examining the impact of child abuse across the continuum of psychosis, from subclinical psychosis to first episode of psychosis (FEP). Methods:The study included a total of 198 individuals divided in three groups: 1) 48 FEP patients, 2) 77 individuals scoring above the 75 th percentile in the Community Assessment of Psychic Experiences (CAPE (1)) which were classified as "High CAPE" group; and 3) 73 individuals scoring below the 25 th percentile classfied as "Low CAPE" group. Childhood abuse (physical and sexual) was assessed using self report instruments. Fisher's exact tests were performed to compare the frequency of individuals exposed to childhood abuse between the groups. Three comparisons were performed: i) FEP vs.Low CAPE; ii) FEP vs. High CAPE and iii) High CAPE vs. Low CAPE. Results:The frequency of individuals exposed to childhood abuse for FEP, High CAPE and Low CAPE groups were 52%, 26% and 1%, respectively. FEP group significantly presented a higer rate of individuals exposed to child abuse compared to Low CAPE (p<.000) and High CAPE groups (p<.004). High CAPE individuals also presented significantly more cases of individuals exposed to child abuse compared to the Low CAPE group (p<.000).Discussion: These results provide support for the existence of an etiological continuum with increasing presence of the risk factor, childhood abuse, underlying a phenotypic continuum of severity from low levels of subclinical psychosis to FEP.

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“…Alemany et al (2011) recently documented the first allelic association with psychotic symptoms, demonstrating that persons Motor abnormalities have also been demonstrated by a number of studies, with dopamine dysregulation a suggested mechanism , MacManus et al, 2011, Mittal et al, 2011 Further work will be necessary in terms of neuro-genetics, imaging, electrophysiology and cognition to understand the ways in which psychotic symptoms contribute to a wide range of psychopathology in general and how these symptoms might contribute to psychosis in particular.…”

Section: Discussionmentioning

confidence: 93%

Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

et al. 2012

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Cannon M. Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies. Psychological Medicine. 2012; 9:1-7. AuthorsIan Kelleher, Dearbhla Connor, Mary C. Clarke, Nina Devlin, Michelle Harley, and Mary Cannon This article is available at e-publications@RCSI: http://epubs.rcsi.ie/psychart/1 -Use LicenceAttribution-Non-Commercial-ShareAlike 1.0 You are free:• to copy, distribute, display, and perform the work.• to make derivative works. Under the following conditions:• Attribution -You must give the original author credit.• Non-Commercial -You may not use this work for commercial purposes.• Share Alike -If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.

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Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences

Cited by 112 publications

References 39 publications

Childhood adversity and psychosis: Examining whether the association is due to genetic confounding using a monozygotic twin differences approach

Childhood adversity and psychosis: Examining whether the association is due to genetic confounding using a monozygotic twin differences approach

Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences

Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

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