Childhood abuse, family history and stressors in older patients with bipolar disorder in relation to age at onset

Thesing, Carisha S.; Stek, Max L.; Grootheest, D.S. van; Ven, Peter M. van de; Beekman, Aartjan T.F.; Kupka, Ralph; Comijs, Hannie C.; Dols, Annemiek

doi:10.1016/j.jad.2015.05.066

Cited by 13 publications

(12 citation statements)

References 31 publications

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“…Ernst et al study additionally did not show significant association of AAO with suicidal attempts. 11 Present study also did not show significant association of AAO with positive family history, lifetime psychosis, lifetime suicidal attempt or psychosis. Nevertheless, many studies have shown the significant association of AAO with positive family history, 9,10,12,22 with psychosis 8,9,23,24 and with suicidal attempts.…”

Section: Discussioncontrasting

confidence: 75%

“…9,12,13,[20][21][22][23] Two studies did not show significant association of AAO and comorbidities. 6,11 Both studies showed no association of AAO with family history of bipolar disorder. Ernst et al study additionally did not show significant association of AAO with suicidal attempts.…”

Section: Discussionmentioning

confidence: 94%

“…5 David et al in 2009 reported that late AAO bipolar patients were more likely to present with psychosis compared with early AAO 6 7,8 Similarly, some of the studies showed higher rates of family history in early AAO 9-11 and others did not find the significant difference. 6,11 Co-morbidity was significantly associated in some studies 12,13 but there was no significant association in other studies. 6,11 There are also conflicting results that geographical situation might affect the AAO.…”

Section: Introductionmentioning

confidence: 97%

“…6,11 Co-morbidity was significantly associated in some studies 12,13 but there was no significant association in other studies. 6,11 There are also conflicting results that geographical situation might affect the AAO. For example, one study conducted in 1665 bipolar patients across different countries (Italy, Argentina, Unites States of America, Spain, Turkey etc) concluded that AAO in these countries were comparable.…”

Section: Introductionmentioning

confidence: 97%

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Age-at-onset and association with clinical features in bipolar inpatients: A case-records-based study from a tertiary hospital in eastern part of Nepal

Adhikari

Mishra

Nepal

et al. 2017

J Psychiatr Assoc Nepal

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Age-at-onset and association with clinical features in bipolar inpatients: A case-records-based study from a tertiary hospital in eastern part of Nepal

Adhikari

Mishra

Nepal

et al. 2017

J Psychiatr Assoc Nepal

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“…The clinical profile of EOBD is more often associated with a family history of mood disorder, whereas LOBD is often associated with brain (i.e. cerebrovascular) diseases, a poorer response to treatment and a higher risk of cognitive deterioration or dementia .…”

Section: Introductionmentioning

confidence: 99%

The clinical course of late‐life bipolar disorder, looking back and forward

et al. 2017

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A relapse rate of 37.5% in 3 years is high, considering that LLBD patients generally have a longer history of disease and were receiving care and medication. The course of LLBD can provide important information on which clinical factors are associated with recurrence. Further phenotyping may reveal unique predictors for outcome, and both course specifiers and clinical variables should be included.

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Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults

Lavin

Buck

Almeida

et al. 2022

Int J Geriat Psychiatry

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Objectives Late‐onset bipolar disorder (LOBD) represents a significant subgroup of bipolar disorder (BD). However, knowledge for this group is mostly extrapolated from small studies in subjects with early/mixed age of illness onset. In this global sample of older adults with BD (OABD: ≥50 years old) we aim to characterize the sociodemographic and clinical presentation of LOBD (≥40 years at BD onset) compared to early‐onset BD (EOBD: <40 years at BD onset). Methods The Global Aging and Geriatric Experiments in Bipolar Disorder consortium provided international data on 437 older age bipolar disorder participants. We compared LOBD versus EOBD on depression, mania, functionality, and physical comorbidities. Exploratory analyses were performed on participants with BD onset ≥50 years old. Results LOBD (n = 105) did not differ from EOBD (n = 332) on depression, mania, global functioning, nor employment status (p > 0.05). Late‐onset bipolar disorder was associated with higher endocrine comorbidities (odds ratio = 1.48, [95%CI = 1.0,12.1], p = 0.03). This difference did not remain significant when subjects with BD onset ≥50 years old were analyzed. Limitations This study is limited by the retrospective nature of the variable age of onset and the differences in evaluation methods across studies (partially overcame by harmonization processes). Conclusion The present analysis is in favor of the hypothesis that LOBD might represent a similar clinical phenotype as classic EOBD with respect to core BD symptomatology, functionality, and comorbid physical conditions. Large‐scale global collaboration to improve our understanding of BD across the lifespan is needed.

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Childhood abuse, family history and stressors in older patients with bipolar disorder in relation to age at onset

Cited by 13 publications

References 31 publications

Age-at-onset and association with clinical features in bipolar inpatients: A case-records-based study from a tertiary hospital in eastern part of Nepal

Age-at-onset and association with clinical features in bipolar inpatients: A case-records-based study from a tertiary hospital in eastern part of Nepal

The clinical course of late‐life bipolar disorder, looking back and forward

Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults

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