Childhood Abuse and Lifetime Psychopathology in a Community Sample

MacMillan, Harriet L.; Fleming, Jan E.; Streiner, David L.; Lin, Elizabeth; Boyle, Michael H.; Jamieson, Ellen; Duku, Eric; Walsh, Christine A.; Wong, Marian Y. L.; Beardslee, William R.

doi:10.1176/appi.ajp.158.11.1878

Cited by 869 publications

(669 citation statements)

References 33 publications

(37 reference statements)

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“…Early life stress, such as that induced by maternal separation, child physical, sexual, and emotional abuse, and general neglect, has been associated with serious psychiatric impairment in adulthood (MacMillan et al, 2001), especially, experience of childhood abuse is prevalent among patients with eating disorders (Wonderlich et al, 1997; see for review). Dysfunction of the hypothalamicpituitary-adrenal gland (HPA) axis is implicated in the pathogenesis of eating disorders (Koo-Loeb et al, 2000;Putignano et al, 2001;Gluck et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

et al. 2011

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Section: Introductionmentioning

confidence: 99%

“…Early life stress is a major risk factor for major depressive disorder and posttraumatic stress disorder (Shea et al, 2005;Kessler et al, 1997;Heim et al, 2001), especially in women (MacMillan et al, 2001;Shea et al, 2005). Women are roughly twice as likely as men to experience depression (Halbreich and Kahn, 2007).…”

Section: Introductionmentioning

confidence: 99%

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

et al. 2011

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“…Some evidence suggests that maltreatment may impart greater risk for the development of internalizing symptoms in females than in males (e.g., refs. [7][8][9]. This differential risk could account, in part, for the higher incidence of internalizing problems in females than in males (10,11).…”

mentioning

confidence: 99%

Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence

Herringa

Birn

Ruttle

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

345

310

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Maltreatment during childhood is a major risk factor for anxiety and depression, which are major public health problems. However, the underlying brain mechanism linking maltreatment and internalizing disorders remains poorly understood. Maltreatment may alter the activation of fear circuitry, but little is known about its impact on the connectivity of this circuitry in adolescence and whether such brain changes actually lead to internalizing symptoms. We examined the associations between experiences of maltreatment during childhood, resting-state functional brain connectivity (rs-FC) of the amygdala and hippocampus, and internalizing symptoms in 64 adolescents participating in a longitudinal community study. Childhood experiences of maltreatment were associated with lower hippocampus-subgenual cingulate rs-FC in both adolescent females and males and lower amygdalasubgenual cingulate rs-FC in females only. Furthermore, rs-FC mediated the association of maltreatment during childhood with adolescent internalizing symptoms. Thus, maltreatment in childhood, even at the lower severity levels found in a community sample, may alter the regulatory capacity of the brain's fear circuit, leading to increased internalizing symptoms by late adolescence. These findings highlight the importance of fronto-hippocampal connectivity for both sexes in internalizing symptoms following maltreatment in childhood. Furthermore, the impact of maltreatment during childhood on both fronto-amygdala and -hippocampal connectivity in females may help explain their higher risk for internalizing disorders such as anxiety and depression.child maltreatment | sex differences | ventromedial prefrontal cortex I n both clinical and community samples, maltreatment during childhood represents one of the strongest risk factors for developing depression and anxiety (1-3). Childhood maltreatment and other adversities account for up to a third of the risk for mood and anxiety disorders (4). Further, depression and anxiety disorders are major public health problems, affecting 15 and 32% of youth, respectively, by the age of 18 y (5). The burden of these disorders is significant, representing the second and fifth leading causes, respectively, of years lived with disability in the United States (6). Some evidence suggests that maltreatment may impart greater risk for the development of internalizing symptoms in females than in males (e.g., refs. 7-9). This differential risk could account, in part, for the higher incidence of internalizing problems in females than in males (10, 11). However, the neurobiological pathways from maltreatment during childhood to the expression of internalizing problems, including potential differences for females and males, remain poorly understood. Such information is crucial for improving the treatment of depression and anxiety disorders and for mitigating the effects of maltreatment during childhood.Both maltreatment during childhood (12) and internalizing disorders (13, 14) have been associated with altered activity in specific b...

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“…The consequences can be both severe and long-lasting (5,6), and may further increase an individual's risk of developing psychological disorders later in life (2,7). The literature generally refers to four categories of child maltreatment: i) physical abuse; ii) sexual abuse; iii) emotional abuse; and iv) physical and emotional neglect (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The relationship between child maltreatment and exposure to traumatic events during later adolescence and young adulthood

Schouwenaars¹,

Murphy²,

Elklit³

2016

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

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Objective: The present study investigated the relationship between different types of childhood maltreatment (emotional abuse, sexual abuse, multiple abuse types, and no abuse) and the occurrence of later traumatic events during later adolescence and young adulthood. Method: Data were collected from a Danish national study conducted by The Danish National Centre for Social Research in 2008 and 2009. A sample of 4718 young adults who were 24 years old was randomly selected using the total birth cohort of children born in 1984. A structured interview was conducted during which participants were asked about a range of traumatic and abusive experiences. Results: A response rate of 63% was achieved for a total sample size of 2980. Chi-squared analyses revealed significant relationships between all child maltreatment groups and direct exposure to 10 of the 13 traumatic events; there were also significant relationships between all child maltreatment groups and indirect exposure to 12 of the 13 traumatic events. Conclusion:The results showed that childhood maltreatment was associated with increased risk of exposure to traumatic events, both directly and indirectly, during adolescence and young adulthood. The findings of this study suggest there is an increased risk of being exposed to both direct and indirect traumas during later adolescence and young adulthood after any form of child maltreatment.

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Childhood Abuse and Lifetime Psychopathology in a Community Sample

Abstract: A history of abuse in childhood increases the likelihood of lifetime psychopathology; this association appears stronger for women than men.

Cited by 869 publications

References 33 publications

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence

The relationship between child maltreatment and exposure to traumatic events during later adolescence and young adulthood

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