Childbirth Education for Multiple Pregnancy

Montgomery, Kristen S.; Cubera, Sabrina; Belcher, Christie; David, Patrick; Funderburk, Heather; Melton, Christa; Fastenau, Michelle

doi:10.1624/105812405x57561

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…In terms of fetal outcomes, moderately elevated blood pressure in multiple pregnancies increases blood flow to the placenta, contributing to decreased risk of preterm birth and low birth weight ( 43 ). Multiple pregnancies have other risks, the major one being prematurity, which is associated with adverse outcomes such as respiratory morbidity, intraventricular hemorrhage, necrotizing enterocolitis, and metabolic disorders ( 23 , 44 ). However, the risk of future cardiovascular disease is not increased ( 45 ), which contrasts with single pregnancies, where HDP is a risk factor for future cardiovascular disease ( 23 , 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

Ca²⁺ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

Cortés,

Alonso,

Vinet

et al. 2024

Biomed Rep

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Fetal growth restriction associated with hypertensive disorders of pregnancy (FGR-HDP) is a prevalent pathology with a higher risk of perinatal morbimortality. In this condition, placental insufficiency and endothelial dysfunction serve key roles. The present prospective cohort study monitored 11 patients with an FGR-HDP and 15 with full-term normotensive pregnancies and studied post-natal intracellular calcium concentration ([Ca 2+ ] i ) signals in human umbilical vein endothelial cells (HUVECs). Small fetuses with placental insufficiency were identified using fetal biometry with Doppler velocimetry. Mean gestational age and birth weight were 31.8±4.1 weeks and 1,260±646 g for FGR-HDP and 39.2±0.8 weeks and 3,320±336 g for normal births, respectively. Abnormal umbilical artery Doppler waveforms were found in 64% of neonates with FGR-HDP. A significant percentage (86%) of FGR newborns were admitted to the neonatal intensive care unit at Gustavo Fricke hospital, Viña del Mar, Chile, with one case of death after birth. [Ca 2+ ] i signals were measured by microfluorimetry in Fluo-3-loaded HUVECs from primary cultures. Altered [Ca 2+ ] i signals were observed in HUVECs from FGR-HDP, where the sustained phase of ATP-induced [Ca 2+ ] i responses was significantly reduced compared with the normotensive group. Also, the [Ca 2+ ] i signals induced with 10 mM Ca 2+ after depletion of internal Ca 2+ stores were significantly higher. The present study provides a better comprehension of the role of altered cytosolic Ca 2+ dynamics in endothelial dysfunction and an in vitro model to assess novel therapeutic approaches for decreasing or preventing complications in FGR-HDP.

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Section: Discussionmentioning

confidence: 99%

Ca²⁺ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

Cortés,

Alonso,

Vinet

et al. 2024

Biomed Rep

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“…Women of African descent are the most likely to have multiple pregnancies, with West African women having the highest rate of 48 in a thousand births (Lyons, 2000). Obesity and iron deficiency in multiple pregnancies could result from an exaggerated physiologic response due to increased placental and fetal mass, and increased blood volume (Montgomery et al, 2005). Anemia has been reported in multiple pregnancies than in singleton pregnancies (Harvey, 1999).…”

Section: Other Factors That Could Affect the Link Between Iron Statusmentioning

confidence: 99%

The Relationship Between Iron Status and Adiposity in Women from Developing Countries: A Review

Aderibigbe

Pisa

Vorster

et al. 2013

Critical Reviews in Food Science and Nutrition

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Scientific reports have shown that iron deficiency is positively associated with adiposity. With the high prevalence of iron deficiency and obesity in developing countries and women being particularly affected, this review was carried out with the aim of elucidating the link between iron status and adiposity in women from developing countries and to examine factors influencing this relationship. An extensive literature search was conducted using several search engines. A systematic approach with prespecified inclusion criteria was used in selecting relevant literature. Eight studies that met the inclusion criteria were selected for review. The relationship between iron status indices and adiposity in women in developing countries varied widely. While some studies observed negative relationships, some reported positive relationships, and others no significant relationships. Furthermore, other factors such as infection, alcohol consumption, type of diet, and genes were shown to affect the relationship between iron status and adiposity in women in developing countries. In conclusion, the possibility of iron status playing a role in adiposity in women from developing countries is likely, and it may be influenced by several other factors as described in the results. Thus, it is recommended that a special research effort should be directed toward this area.

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“…It is well established that twin pregnancies involve more risks during pregnancy and delivery than singleton pregnancies. This elevated risk can be attributed not only to the high number of premature births and/or growth restriction but also to delivery complications among term pregnancies, though the latter cause has declined (Montgomery et al, 2005a(Montgomery et al, , 2005b.…”

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confidence: 99%

Hospitalization in Adolescence and Young Adulthood Among Twins and Singletons: A Swedish Cohort Study of Subjects Born Between 1973 and 1983

et al. 2013

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Children born with non-optimal birth characteristics -that is, are small for gestational age and/or preterm -have an increased risk for several long-term effects such as neurological sequelae and chronic disease. The purpose of this study was to examine whether twins exhibited a different outcome, compared with singletons, in terms of hospitalization during adolescence and early adulthood, and to what extent differences remain when considering the divergence in birth characteristics between singletons and twins. Persons born between 1973 and 1983 in Sweden and surviving until age 13 were included and followed until the end of 2006. Data on birth characteristics, parental socio-demographic factors, and hospitalizations were collected from national registers. Adjusting for parental socio-demographic factors, twins had a higher risk of being hospitalized than singletons (odds ratio, OR = 1.17, 95% confidence interval, CI = 1.10-1.25) and more often due to 'Congenital anomalies' (OR = 1.18, 95% CI = 1.06-1.28), 'Infections' (OR = 1.14; 95% CI = 1.08-1.20), 'External causes of illness' (OR = 1.10, 95% CI = 1.06-1.15), and 'Diseases of the nervous system' (OR = 1.18, 95% CI = 1.10-1.26). Stratifying for birth characteristics, this difference diminishes, and for some diagnoses non-optimal twins seem to do slightly better than non-optimal singletons. Thus, twins with non-optimal birth characteristics had a lower risk of hospitalization than non-optimal singletons on, for example, 'Congenital anomalies' and 'Diseases of the nervous system' (OR = 0.86, 95% CI = 0.77-0.96; OR = 0.88, 95% CI = 0.81-0.97, respectively) and Total (any) hospitalization (OR = 0.87, 95% CI = 0.83-0.92). Among those with optimal birth characteristics, twins had an increased hospitalization due to 'External causes of illness' (OR = 1.07, 95% CI = 1.02-1.13) compared with optimal singletons. Twins have higher hospitalization rates than singletons. In stratifying for birth characteristics, this difference diminishes, and for some diagnoses, non-optimal twins seem to do less poorly than non-optimal singletons.

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Childbirth Education for Multiple Pregnancy

Cited by 4 publications

References 10 publications

Ca²⁺ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

Ca²⁺ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

The Relationship Between Iron Status and Adiposity in Women from Developing Countries: A Review

Hospitalization in Adolescence and Young Adulthood Among Twins and Singletons: A Swedish Cohort Study of Subjects Born Between 1973 and 1983

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Childbirth Education for Multiple Pregnancy

Cited by 4 publications

References 10 publications

Ca2+ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

Ca2+ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

The Relationship Between Iron Status and Adiposity in Women from Developing Countries: A Review

Hospitalization in Adolescence and Young Adulthood Among Twins and Singletons: A Swedish Cohort Study of Subjects Born Between 1973 and 1983

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Ca²⁺ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

Ca²⁺ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder