Childbearing Depression and Childhood Aggression

Hendricks, Katherine; Liu, Jianghong

doi:10.1097/nmc.0b013e3182482c5e

Cited by 15 publications

(7 citation statements)

References 39 publications

(54 reference statements)

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“…Four SRs reported on a variety of outcomes. One155 suggested that chronic maternal depression may play an important role in a child being overweight while another156 reported that when maternal depression exists, early childhood aggression is more likely to occur. Parental prenatal and postnatal depression was found to be responsible for increasing the mean rate of behavioural and emotional problems157 and antenatal depression was found to affect children’s conduct problems and antisocial behaviours 158…”

Section: Resultsmentioning

confidence: 99%

Evidence available for patient-identified priorities in depression research: results of 11 rapid responses

Sebastianski

Gates

et al. 2019

BMJ Open

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ObjectivesPatient priority setting projects (PPSPs) can reduce research agenda bias. A key element of PPSPs is a review of available literature to determine if the proposed research priorities have been addressed, identify research gaps, recognise opportunities for knowledge translation (KT) and avoid duplication of research efforts. We conducted rapid responses for 11 patient-identified priorities in depression to provide a map of the existing evidence.DesignEleven rapid responses.Data sourcesSingle electronic database (PubMed).Eligibility criteriaEach rapid response had unique eligibility criteria. For study designs, we used a stepwise inclusion process that started with systematic reviews (SRs) if available, then randomised controlled trials and observational studies as necessary.ResultsFor all but one of the rapid responses we identified existing SRs (median 7 SRs per rapid response, range 0–179). There were questions where extensive evidence exists (ie, hundreds of primary studies), yet uncertainties remain. For example, there is evidence supporting the effectiveness of many non-pharmacological interventions (including psychological interventions and exercise) to reduce depressive symptoms. However, targeted research is needed that addresses comparative effectiveness of promising interventions, specific populations of interest (eg, children, minority groups) and adverse effects.ConclusionsWe identified an extensive body of evidence addressing patient priorities in depression and mapped the results and limitations of existing evidence, areas of uncertainty and general directions for future research. This work can serve as a solid foundation to guide future research in depression and KT activities. Integrated knowledge syntheses bring value to the PPSP process; however, the role of knowledge synthesis in PPSPs and methodological approaches are not well defined at present.

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Section: Resultsmentioning

confidence: 99%

Evidence available for patient-identified priorities in depression research: results of 11 rapid responses

Sebastianski

Gates

et al. 2019

BMJ Open

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“…For example, aggression level may affect the decision to initiate or increase medication dosage in pediatric ADHD treatment [ 36 ]. Regardless of the controversy over whether to consider impulsive aggression as an independent categorical diagnosis like a disorder [ 37 ] or a measurable symptom secondary to some other diagnostic entity like fever or pain [ 32 , 38 ], it can greatly impact an individual’s development and health, or even lead to high economic and medical burden for families and communities [ 39 - 41 ]. This paper does not aim to address the dispute over the clinical perception of aggression by joining any side or to unduly correlate 16p13.11 microduplication with the aggression phenotype.…”

Section: Discussionmentioning

confidence: 99%

Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study

Li¹,

Hojlo²,

Chennuri³

et al. 2021

J Med Internet Res

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Background 16p13.11 microduplication syndrome has a variable presentation and is characterized primarily by neurodevelopmental and physical phenotypes resulting from copy number variation at chromosome 16p13.11. Given its variability, there may be features that have not yet been reported. The goal of this study was to use a patient “self-phenotyping” survey to collect data directly from patients to further characterize the phenotypes of 16p13.11 microduplication syndrome. Objective This study aimed to (1) discover self-identified phenotypes in 16p13.11 microduplication syndrome that have been underrepresented in the scientific literature and (2) demonstrate that self-phenotyping tools are valuable sources of data for the medical and scientific communities. Methods As part of a large study to compare and evaluate patient self-phenotyping surveys, an online survey tool, Phenotypr, was developed for patients with rare disorders to self-report phenotypes. Participants with 16p13.11 microduplication syndrome were recruited through the Boston Children's Hospital 16p13.11 Registry. Either the caregiver, parent, or legal guardian of an affected child or the affected person (if aged 18 years or above) completed the survey. Results were securely transferred to a Research Electronic Data Capture database and aggregated for analysis. Results A total of 19 participants enrolled in the study. Notably, among the 19 participants, aggression and anxiety were mentioned by 3 (16%) and 4 (21%) participants, respectively, which is an increase over the numbers in previously published literature. Additionally, among the 19 participants, 3 (16%) had asthma and 2 (11%) had other immunological disorders, both of which have not been previously described in the syndrome. Conclusions Several phenotypes might be underrepresented in the previous 16p13.11 microduplication literature, and new possible phenotypes have been identified. Whenever possible, patients should continue to be referenced as a source of complete phenotyping data on their condition. Self-phenotyping may lead to a better understanding of the prevalence of phenotypes in genetic disorders and may identify previously unreported phenotypes.

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“…Untreated postpartum depression can have effects on infants’ wellbeing into adolescence, including poor cognitive functioning, violent behavior, and externalizing disorders [ 7 ]. Further, young children of depressed mothers have been found to exhibit more fussiness and aggression relative to young children of healthy mothers [ 1 , 8 ]. Behavioral problems in young children, particularly boys, are also specifically tied to paternal depression beyond the effects seen from maternal depression [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Transition to Adulthood in Children of Depressed Parents: Long-Term Follow-Up Data from the Family Talk Preventive Intervention Project

Myers

Gladstone

Beardslee

2023

IJERPH

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Little is known about the effects of parental depression on offspring as they transition to adulthood—a challenging time developmentally, when late adolescents must separate from home, achieve intimate relationships, and develop a sense of identity. We present long-term quantitative and qualitative data from early adolescents with a depressed parent who were randomized to one of two family-based preventive interventions and followed over time, across the transition to young adulthood. Specifically, we present clinical measures of psychopathology and Likert-scale questionnaire data from young adults and their parents regarding the transition to adulthood and perceptions of the interventions. We also report in-depth qualitative interview data from young adults about the effects of parental depression on their transition to adulthood. Findings suggest that leaving home, establishing relationships, and coping with stressors may be challenging for emerging adults. Furthermore, the interviews highlight the importance of siblings, the burden of parental depression, and the development of self-understanding and empathy in young adults who grew up with a depressed parent. Data suggest that clinicians, policy makers, educators, and employers must address the preventive and clinical needs of young people and their families as they transition to young adulthood after growing up with depressed parents.

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Childbearing Depression and Childhood Aggression

Cited by 15 publications

References 39 publications

Evidence available for patient-identified priorities in depression research: results of 11 rapid responses

Evidence available for patient-identified priorities in depression research: results of 11 rapid responses

Underrepresentation of Phenotypic Variability of 16p13.11 Microduplication Syndrome Assessed With an Online Self-Phenotyping Tool (Phenotypr): Cohort Study

The Transition to Adulthood in Children of Depressed Parents: Long-Term Follow-Up Data from the Family Talk Preventive Intervention Project

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