Childbearing and mortality among women with anorexia nervosa

Papadopoulos, Fotios C.; Karamanis, Georgios; Brandt, Lena; Ekbom, Anders; Ekselius, Lisa

doi:10.1002/eat.22051

Cited by 18 publications

(9 citation statements)

References 54 publications

(24 reference statements)

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“…These results indicate that women with histories of AN or EDNOS may be experiencing greater delay or disruption to their reproduction due to their ED and that these factors cannot be fully explained by shared early life environment or genetics. These findings are important in light of prior research indicating that childbearing is associated with reduced risk of mortality among women with AN (Papadopoulos et al, 2013); reproductive health screenings may be especially critical for the wellbeing of women with histories of AN or EDNOS.…”

Section: Discussionmentioning

confidence: 73%

Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest‐aged sisters

Tabler

Utz

Smith

et al. 2018

Intl J Eating Disorders

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Clinicians should consider ED type and family fertility histories when addressing the long-term reproductive health needs of women with prior AN, BN, or EDNOS diagnosis. Women previously diagnosed with AN or EDNOS likely experience the greatest reductions and delays in reproduction across their lifespan. Reproductive health screenings may be especially critical for the wellbeing of women with a history of AN or EDNOS.

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Section: Discussionmentioning

confidence: 73%

Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest‐aged sisters

Tabler

Utz

Smith

et al. 2018

Intl J Eating Disorders

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“…Pregnancy has also been examined in relation to suicidality and AN. In a population-based analysis, 5251 females with AN were evaluated, comparing suicide rates between a parous and a nulliparous group [ 46 ]. Suicide was the most common cause of death in both groups.…”

Section: Reviewmentioning

confidence: 99%

The current status of suicide and self-injury in eating disorders: a narrative review

2014

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The aim of this paper is to review recent literature on suicide and self-injury in eating disorders (ED) including anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Among psychiatric diagnoses, EDs are associated with increased mortality rates, even when specialized treatment is available. Of the mortalities that are reported in individuals with EDs, suicide is among the most commonly reported causes of death. Additionally, suicidal and non-suicidal self-injurious behaviors occur frequently in this clinical population. A literature search was undertaken using the databases of Medline/PubMed and PsycInfo to identify papers describing suicidality in individuals with ED diagnoses. The authors identified studies and review articles published between 2005-2013 (inclusive) that describe the relationship between EDs and suicide, and associated behaviors including self-injurious behaviors, or non-suicidal self-injury (NSSI). The initial search resulted in 1095 papers that met the a priori search criteria. After careful review, 66 papers were included. The majority of papers described clinical cohorts that were studied longitudinally. The diagnosis described most frequently in selected studies was AN. There are limited current data about the prevalence of suicide and NSSI among individuals with EDs. Among the published studies that focus specifically on the relationship between EDs and suicidality, most describe AN in more detail than other EDs. Nonetheless, rates of mortality, and specifically rates of suicide, are undeniably high in ED populations, as are the rates of self-harm. Therefore, it is critical for clinicians and caretakers to carefully evaluate these patients for suicide risk and to refer promptly for appropriate treatment.

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“…A major concern is a high risk for suicide, a common cause of death in AN 21 . Among adolescents with AN, relapses occur following inpatient hospital admissions in 30% before medical recovery, however, about 70–75% completely recover over 5–10 years, with a low later risk of relapse 22, 23 .…”

Section: Introductionmentioning

confidence: 99%

Endocrine consequences of anorexia nervosa

Misra

Klibanski

2014

The Lancet Diabetes & Endocrinology

255

179

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Summary Anorexia nervosa (AN) is prevalent in adolescents and young adults, and endocrine changes include hypothalamic amenorrhea, a nutritionally acquired growth hormone resistance with low insulin like growth factor-1 (IGF-1), relative hypercortisolemia, decreases in leptin, insulin, amylin and incretins, and increases in ghrelin, PYY and adiponectin. These changes in turn have deleterious effects on bone, and may affect neurocognition, anxiety, depression and eating disorder psychopathology. Low bone density is particularly concerning; clinical fractures occur and changes in both bone microarchitecture and strength estimates have been reported. Recovery causes improvement of many, but not all, hormonal changes, and deficits in bone accrual may persist despite recovery. Physiologic, primarily transdermal, estrogen replacement increases bone density in adolescents, although catch-up is incomplete. In adults, oral estrogen co-administered with rhIGF-1 in one study, and bisphosphonates in another increased bone density, though not to normal. More studies are necessary to determine the optimal therapeutic approach in AN.

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Childbearing and mortality among women with anorexia nervosa

Abstract: Childbearing is associated with lower mortality among women with AN.

Cited by 18 publications

References 54 publications

Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest‐aged sisters

Variation in reproductive outcomes of women with histories of bulimia nervosa, anorexia nervosa, or eating disorder not otherwise specified relative to the general population and closest‐aged sisters

The current status of suicide and self-injury in eating disorders: a narrative review

Endocrine consequences of anorexia nervosa

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