Child and Adolescent Psychopharmacology Update

McVoy, Molly; Findling, Robert L.

doi:10.1016/j.psc.2008.11.002

Cited by 23 publications

(13 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results indicating that adolescents are more responsive to exercise as a treatment than adults are important given the relative vulnerability of adolescents (vs. adults) to addiction (Doremus-Fitzwater et al 2010; Spear 2009; but see Schramm-Sapyta et al 2011; Kerstetter and Kantak 2007), and they agree with previous work showing greater treatment success in drug-prone females (vs. males) (Campbell et al 2002; Carroll et al 2001a, b; Cosgrove et al 2002). Furthermore, exercise may be advantageous over the use of pharmaceutical interventions in adolescents who are still undergoing critical development (Koelch et al 2008; McVoy and Findling 2009). …”

Section: Discussionmentioning

confidence: 99%

Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats

2012

View full text Add to dashboard Cite

Rationale Concurrent access to an exercise wheel decreases cocaine self-administration under short access (5 h/day for 5 days) conditions and suppresses cocaine-primed reinstatement in adult rats. Objective The effect of exercise (wheel running) on the escalation of cocaine intake during long access (LgA, 6 h/day for 26 days) conditions was evaluated. Methods Adolescent and adult female rats acquired wheel running, and behavior was allowed to stabilize for 3 days. They were then implanted with an iv catheter and allowed to self-administer cocaine (0.4 mg/kg, iv) during 6-h daily sessions for 16 days with concurrent access to either an unlocked or a locked running wheel. Subsequently, for ten additional sessions, wheel access conditions during cocaine self-administration sessions were reversed (i.e., locked wheels became unlocked and vice versa). Results In the adolescents, concurrent access to the unlocked exercise wheel decreased responding for cocaine and attenuated escalation of cocaine intake irrespective of whether the locked or unlocked condition came first. However, cocaine intake increased when the wheel was subsequently locked for the adolescents that had initial access to an unlocked wheel. Concurrent wheel access either before or after the locked wheel access did not reduce cocaine intake in adults. Conclusions Wheel running reduced cocaine intake during LgA conditions in adolescent but not adult rats, and concurrent access to the running wheel was necessary. These results suggest that exercise prevents cocaine seeking and that this effect is more pronounced in adolescents than adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats

2012

View full text Add to dashboard Cite

show abstract

“…Compared with adults, children have rapid tissue growth, higher ratio of liver organ to tissue mass, greater extracellular tissue water and glomerular filtration rates, lower protein binding, reduced fat-tissue mass, and more active hormone release in adolescence. 13 Thus, children may require different dosing strategies and experience more frequent and unique side effects than adults.…”

Section: Susceptibility For Youth To Develop Antipsychotic-induced Wementioning

confidence: 99%

Metabolic consequences of second-generation antipsychotics in youth: appropriate monitoring and clinical management

Krill

Kumra

2014

AHMT

View full text Add to dashboard Cite

ObjectiveTo review the metabolic consequences of second-generation antipsychotics in youth and current monitoring and intervention guidelines for optimal treatment.BackgroundSecond-generation antipsychotics have largely replaced the use of first-generation antipsychotics in treating psychotic disorders in youth. In addition, there has been a dramatic increase in using these medications to treat a variety of nonpsychotic disorders. These medications have significant metabolic side effects, including weight gain. This raises concern, given the problem of pediatric obesity.Materials and methodsA review of current literature looking at prescribing practices and possible reasons for the increased use of second-generation antipsychotics in children and adolescents was conducted. Review of the mechanisms for why youth may be particularly vulnerable to the metabolic consequences (particularly weight gain) was similarly completed. In addition, data supporting the efficacy, rationale, and unique side-effect profile of each individual second-generation drug were evaluated to help inform providers on when and what to prescribe, along with current monitoring practices. The current evidence base for possible interventions regarding the management of antipsychotic-induced weight gain was also evaluated.Results and conclusionOn the basis of the literature review, there are several speculated reasons for the increase in prescriptions of second-generation antipsychotics. The choice of antipsychotic for youth should be based upon the disorder being treated along with the unique side-effect profile for the most commonly used second-generation antipsychotics. Monitoring strategies are also individualized to each antipsychotic. The current interventions recommended for antipsychotic-induced weight gain include lifestyle management, switching medication to a drug with a lower propensity for weight gain, and pharmacologic (particularly metformin) treatment.

show abstract

“…This trend is similar to those reported by other studies; both among children and in adults. 29,30 SSRI are generally free of sedative effects and safer at higher doses. Better tolerability, combined with 32 Most of the patients (65.34%) received atypical antipsychotics.…”

mentioning

confidence: 99%

A study on drug prescribing pattern in psychiatry out-patient department from a tertiary care teaching hospital

Rode

Ajagallay

Salankar

et al. 2014

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Child and Adolescent Psychopharmacology Update

Cited by 23 publications

References 132 publications

Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats

Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats

Metabolic consequences of second-generation antipsychotics in youth: appropriate monitoring and clinical management

A study on drug prescribing pattern in psychiatry out-patient department from a tertiary care teaching hospital

Contact Info

Product

Resources

About