Chilblain‐like lesions on feet and hands during the COVID‐19 Pandemic

Landa, N.; Mendieta-Eckert, Marta; Fonda‐Pascual, Pablo; Iturrioz, Teresa

doi:10.1111/ijd.14937

Cited by 189 publications

(267 citation statements)

References 7 publications

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“…We suggest that Google Trends monitoring of taste and smell loss searches is no longer a reliable marker for COVID-19 cases, as these symptoms become common knowledge. The same limitations will likely apply to new COVID-19 symptoms that are being discovered, such as skin lesions 19 , impairment of chemesthesis (a chemosensory modality that allows the perception of burning, cooling or tingling triggered by molecules) 18 , and more 16 .…”

Section: Discussionmentioning

confidence: 99%

Utility and limitations of Google searches on sensory loss as markers for new COVID-19 cases

Asseo

Fierro

Slavutsky

et al. 2020

Preprint

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Web tools are widely used among population to obtain health related information, and these data are often employed for public health monitoring. Here we analyzed searches related to smell loss and taste loss, recently linked to COVID-19, as well as sight loss and hearing loss, not included in the COVID-19 symptoms list. Google Trends results per region (Italy) or state (United States) over several weeks were compared to the number of new cases prevalence in that geographical area. Taste and smell loss searches were correlated with each other, and, during a limited time window, with new COVID-19 cases. However, this correlation decreased with time, attributable, at least in part, to media coverage. As new symptoms are being discovered for COVID-19 and the pandemic continues to spread around the globe, the lesson learned here, that correlation between public interest in novel symptoms of infectious disease has an initial spike (the "surprise rise") and subsequently goes to a new baseline due to "knowledge saturation", is of general and practical value for the public.Supplementary Figure S1 repeats the calculation presented in Figure 1 for the 22-28 April week. This clearly illustrates the current lack of correlation between the number of new cases in each region (Italy) or state (US) and the popularity of Google searches on either taste or smell loss.

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Section: Discussionmentioning

confidence: 99%

Utility and limitations of Google searches on sensory loss as markers for new COVID-19 cases

Asseo

Fierro

Slavutsky

et al. 2020

Preprint

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“…smell and taste disorders), [16][17][18] others much rarer (such as frostbite). [19] It is of utmost importance to gain a better understanding of the speci c symptoms of SARS-CoV-2 infection in primary care settings in order to help GPs triage patients and anticipate medical follow-up.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of SARS-CoV-2 patients: a French cross-sectional study in primary care

Sebo

Tudrej

Lourdaux³

et al. 2020

Preprint

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Background: The early identification of patients suffering from SARS-CoV-2 infection in primary care is of outmost importance in the current pandemic.Aim: To gain a better understanding of the specific symptoms of SARS-CoV-2 infection in primary care.Design and setting: We conducted a cross-sectional study between March 24 and May 7, 2020, involving consecutive patients undergoing RT-PCR testing in two community-based laboratories in Lyon (France) for a suspicion of COVID-19.Methods: We examined the association between various symptoms and a positive test using univariate and multivariate logistic regression, adjusted for clustering within the laboratories.Results: Of the 1561 patients tested, 1543 agreed to participate (participation rate: 99%). Among them, 253 were positive for SARS-Cov-2 (16%). In multivariate analysis, loss of taste (OR 3.8 [95%CI 3.3-4.4], p-value<0.001), loss of smell (OR 3.0 [95%CI 1.9-4.8], p-value<0.001), muscle pain (OR 1.6 [95%CI 1.2-2.0], p-value 0.001) and dry nose (OR 1.3 [95%CI 1.1-1.6], p-value 0.01) were significantly associated with a positive result. The strength of association with taste and smell disorders was higher for symptom combinations (OR 6.5 [95%CI 3.9-10.8] for loss of taste and smell, OR 6.7 [95%CI 5.9-7.5] for loss of taste or smell). In contrast, sore throat (OR 0.6 [95%CI 0.4-0.8], p-value 0.003), stuffy nose (OR 0.7 [95%CI 0.6-0.7], p-value<0.001), diarrhea (OR 0.6 [95%CI 0.5-0.6], p-value<0.001) and dyspnea (OR 0.5 [95%CI 0.3-0.7], p-value<0.001) were inversely associated with a positive test.Conclusion: Our data could further facilitate targeted screening and contribute to the triage and early identification of new clusters of cases.

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“…More speculatively, while the inflammatory arm of the RAS produces TNF, IL-6, and other pro-inflammatory cytokines without producing interferon, ACE cleaves bradykinin, a known suppressor of interferon, and so might lead to increased interferon in some individuals (Seliga et al, 2018). Some individuals with a particular genetic predisposition may produce high levels of interferon, and these may be the individuals who develop "COVID toes" (Landa et al, 2020;Zhang et al, 2020). This predisposition may include those genes with risk alleles in systemic lupus erythematosus (SLE) that have a propensity for high interferon production (Ghodke-Puranik and Niewold, 2015).…”

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confidence: 99%

The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications

Diamond

2020

Journal of Experimental Medicine

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The renin–angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has not been explored fully as a druggable target. The abbreviated description of the RAS suggests that its dysregulation may be at the center of COVID-19.

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Chilblain‐like lesions on feet and hands during the COVID‐19 Pandemic

Cited by 189 publications

References 7 publications

Utility and limitations of Google searches on sensory loss as markers for new COVID-19 cases

Utility and limitations of Google searches on sensory loss as markers for new COVID-19 cases

Clinical characteristics of SARS-CoV-2 patients: a French cross-sectional study in primary care

The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications

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