Chikungunya-virus-specific CD4+T cells are associated with chronic chikungunya viral arthritic disease in humans
James Chang,
Rimjhim Agarwal,
Fernanda H Côrtes
et al.
Abstract:SUMMARYChikungunya virus (CHIKV) is a mosquito-borne re-emerging viral infection that can cause chronic chikungunya viral arthritic disease (CHIKVD), which is characterized by incapacitating arthralgia and inflammation that can last for months to years following infection. Despite CHIKV outbreaks occurring worldwide and several vaccines currently in development, immune responses to CHIKV in humans remains largely understudied, and targets of T cell response are currently unknown. In this study, we tested perip… Show more
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