Chikungunya Virus Seroprevalence and Associated Factors among Hospital Attendees in Two States of Southwest Nigeria: A Preliminary Assessment

Olajiga, Olayinka; Adesoye, Olajumoke E.; Emilolorun, Adewale P.; Adeyemi, Abiodun J.; Adeyefa, Emmanuel O.; Aderibigbe, I.A.; Adejumo, Salmot A.; Adebimpe, Wasiu Olalekan; Opaleye, Oluyinka Oladele; Sule, Waidi Folorunso; Oluwayelu, Daniel Oladimeji

doi:10.1080/08820139.2017.1319383

Cited by 15 publications

(20 citation statements)

References 36 publications

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“…Second , in the majority of the analyzed maternal/neonatal cohorts, only symptomatic neonatal infections were reported which might have underestimated the true MTCT-risk. Third , we could not identify published cohorts with an English abstract with pertinent data for our quantitative data synthesis from the majority of countries with recent CHIKV outbreaks; such as outbreaks in African[ 5 ] [ 12 ] and Asian countries[ 14 , 95 – 97 ], including large outbreaks in India[ 98 – 104 ] after the 2005 reemergence of CHIKV in India, outbreaks in the Carribeans [ 32 , 105 , 106 ], Pacific Island[ 78 ] and Saudi Arabia. [ 107 ] Language-bias is also a possible reason for this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…Chikungunya virus (CHIKV) is a remerging arbovirus[ 1 – 5 ] in the family of Togaviridae , genus Alphavirus that is transmitted by the Aedes spp . mosquitos A .…”

Section: Introductionmentioning

confidence: 99%

“…[ 7 ] It was first identified in Tanzania in 1953[ 8 ], and the name comes from a Makonde word that means “that which bends up” due to the position taken by patients suffering from the severe joint pain. [ 9 , 10 ] Since then, it has caused outbreaks in Africa[ 5 , 11 , 12 ], Indian Ocean islands, South East Asia [ 13 – 15 ], Central and South America[ 16 – 18 ], US territories[ 19 ] and Europe. [ 20 – 23 ] CHIKV has now been identified in 94 countries worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

Contopoulos‐Ioannidis

Newman-Lindsay

Chow

et al. 2018

PLoS Negl Trop Dis

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BackgroundChikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation.MethodologyWe performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis). We searched PubMed (last search 3/2017) for articles, of any study design, with any of the above outcomes. We calculated the overall risk of MTCT, APFDs and risk of symptomatic neonatal disease by simple pooling. For endpoints with ≥5 events in more than one study, we also synthesized the data by random-effect-model (REM) meta-analysis.Principal findingsAmong 563 identified articles, 13 articles from 8 cohorts were included in the quantitative data synthesis and 33 articles in the qualitative data synthesis. Most cohorts reported data only on symptomatic rather than on all neonatal infections. By extrapolation also of these data, the overall pooled-MTCT-risk across cohorts was at least 15.5% (206/1331), (12.6% by REMs). The pooled APFD-risk was 1.7% (20/1203); while the risk of CHIKV-confirmed-APFDs was 0.3% (3/1203). Overall, the pooled-risk of symptomatic neonatal disease was 15.3% (203/1331), (11.9% by REMs). The pooled risk of symptomatic disease was 50.0% (23/46) among intrapartum vs 0% (0/712) among antepartum/peripartum maternal infections. Infected newborns, from maternal infections during gestation were either asymptomatic or presented within their first week of life, but not at birth, with fever, irritability, hyperalgesia, diffuse limb edema, rashes and occasionally sepsis-like illness and meningoencephalitis. The pooled-risk of neonatal death was 0.6% (5/832) among maternal infections and 2.8% (5/182) among neonatal infections; long-term neurodevelopmental delays occurred in 50% of symptomatic neonatal infections.Conclusions/SignificancePublished cohorts with data on the risk to the fetus and/or newborn from maternal CHIKV-infections during gestation were sparse compared to the number of recently reported CHIKV-infection outbreaks worldwide; however perinatal infections do occur, at high rates during intrapartum period, and can be related to neonatal death and long-term disabilities.

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Section: Discussionmentioning

confidence: 99%

“…Chikungunya virus (CHIKV) is a remerging arbovirus[ 1 – 5 ] in the family of Togaviridae , genus Alphavirus that is transmitted by the Aedes spp . mosquitos A .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

Contopoulos‐Ioannidis

Newman-Lindsay

Chow

et al. 2018

PLoS Negl Trop Dis

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“…Even though CHIKV infections have not been officially reported in Ghana, autochthonous cases or outbreaks have been reported in Ghana's neighbouring countries such as Burkina Faso, Ivory Coast, Benin, and Nigeria in recent years [18,19]. This coupled with the presence of an active vector population in Ghana, international travel, and trade among West African countries increases the risk of an outbreak in the nearest future.…”

Section: Introductionmentioning

confidence: 99%

Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana

et al. 2021

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Background Chikungunya is now of public health concern globally due to its re-emergence in endemic areas and introduction into new areas of the world. Worldwide, the vectors for transmission of the chikungunya virus are Aedes mosquitoes and these are prevalent in Ghana. Despite its global significance, the true burden of chikungunya virus infection in Ghana is largely unknown and the threat of outbreak remains high owing to international travel. This study sought to determine chikungunya virus infection among febrile patients suspected of having malaria infections at some selected health facilities in the Ashanti, Bono East, and Bono Regions of Ghana. Methodology This cross-sectional study recruited six hundred (600) febrile patients suspected of having malaria who submitted their clinical samples to the laboratories of the selected health facilities for the diagnosis of their infections. Five to ten millilitres (5-10ml) of venous blood were collected from each study participant. Sera were separated and tested for anti-chikungunya (IgM and IgG) antibodies using InBios ELISA kit following the manufacturer’s instruction. Samples positive for chikungunya IgM and IgG were selected and tested for chikungunya virus RNA using Reverse Transcription-quantitative Polymerase Chain Reaction. Malaria Rapid Diagnostic Test kits were used to screen the participants for malaria. Structured questionnaires were administered to obtain demographic and clinical information of the study participants. Result Of the 600 samples tested, the overall seroprevalence of chikungunya was 6%. The seroprevalence of chikungunya IgM and IgG antibodies were 1.8% and 4.2% respectively. None of the chikungunya IgM and IgG positive samples tested positive for chikungunya RNA by RT-qPCR. Of the 600 samples, tested 32.3% (194/600) were positive for malaria parasites. Malaria and chikungunya co-infection was detected in 1.8% (11/600) of the participants. Conclusion Findings from the current study indicate low-level exposure to the chikungunya virus suggesting the virus is circulating and potentially causing morbidity in Ghana.

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“…This genotype circulates in the western sub-Saharan regions of Africa and hasn’t been identified outside of this region. It has been documented in periodic outbreaks in Senegal and Nigeria and is typically associated with dengue-like illness accompanied by arthralgia [26,27,45,90,115,116,117,118]. In children, the disease is a minor and self-limiting febrile illness with no debilitating or neurological sequelae reported, even in recent outbreaks (Table 1) [45].…”

Section: Chikv In Neonates and Children After Global Expansionmentioning

confidence: 99%

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

Barr

Vaidhyanathan

2019

Viruses

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Chikungunya virus (CHIKV) was first extensively described in children during outbreaks in India and South Asia during the mid-1960s. Prior to the 2005 emergence of CHIKV on Reunion Island, CHIKV infection was usually described as a dengue-like illness with arthralgia in Africa and febrile hemorrhagic disease in Asia. Soon after the 2005 emergence, severe CNS consequences from vertical and perinatal transmission were described and as CHIKV continued to emerge in new areas over the next 10 years, severe manifestation of infection and sequelae were increasingly reported in infants and neonates. The following review describes the global reemergence and the syndromes of Chikungunya fever (CHIKF) in infants and children. The various manifestations of CHIKF are described and connected to the viral lineage that was documented in the area at the time the disease was described. The data show that certain manifestations of CHIKF occur with specific viral lineages and genetic motifs, which suggests that severe manifestations of CHIKF in the very young may be associated with the emergence of new viral lineages.

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Chikungunya Virus Seroprevalence and Associated Factors among Hospital Attendees in Two States of Southwest Nigeria: A Preliminary Assessment

Cited by 15 publications

References 36 publications

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis

Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana

Chikungunya in Infants and Children: Is Pathogenesis Increasing?

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