Chikungunya virus infection in human microglial C20 cells induces mitochondria-mediated apoptosis
Narendra Kumar,
Rashmi Santhoshkumar,
Manjunatha M. Venkataswamy
Abstract:IntroductionChikungunya virus (CHIKV) infection is associated with acute clinical manifestations and chronic joint inflammation. CHIKV has emerged as a significant causative agent of central nervous system (CNS) complications, including encephalitis and related sequelae. Microglial cells, crucial for immune responses and tissue repair in the CNS, play a vital role in the host response to viral infections, with their activation potentially leading to either protection or pathology. In this study, the infection … Show more
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