Chikungunya infection in Malaysia: Comparison with dengue infection in adults and predictors of persistent arthralgia

Zim, Mohd Arif Mohd; Sam, I‐Ching; Omar, Sharifah Faridah Syed; Chan, Yoke Fun; AbuBakar, Sazaly; Kamarulzaman, Adeeba

doi:10.1016/j.jcv.2012.10.019

Cited by 64 publications

(32 citation statements)

References 27 publications

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“…Arthralgia experienced by CHIKV-infected patients closely resembles the symptoms induced by other viruses including arthritogenic alphaviruses such as RRV and BFV [53,126]. Myalgia is also frequently observed, its prevalence varying from one study to another [83,124,132], predominantly in the arms, thighs and calves.…”

Section: Clinical Presentation Of Chikungunya In Human: More Than a Bmentioning

confidence: 82%

“…Anti-CHIKV immunoglobulin M (IgM) and immunoglobulin G (IgG) are detected in the sera of infected patients during the acute phase of disease [59,83,91,95]. These antibodies exhibit a high in vitro neutralizing activity and in vivo studies have demonstrated the importance of anti-CHIKV neutralizing antibodies in the protection against CHIKV infection (see below, Immunotherapy).…”

Section: Adaptive Immunity To Chikv Infectionmentioning

confidence: 99%

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Chikungunya virus pathogenesis: From bedside to bench

Couderc

Lecuit

2015

Antiviral Research

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Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then reached India and Southeast Asia. More recently, CHIKV has emerged in the Americas, first reaching the Caribbean and now extending to Central, South and North America. It is therefore considered a major public health and economic threat. CHIKV causes febrile illness typically associated with debilitating joint pains. In rare cases, it may also cause central nervous system disease, notably in neonates. Joint symptoms may persist for months to years, and lead to arthritis. This review focuses on the spectrum of signs and symptoms associated with CHIKV infection in humans. It also illustrates how the analysis of clinical and biological data from human cohorts and the development of animal and cellular models of infection has helped to identify the tissue and cell tropisms of the virus and to decipher host responses in benign, severe or persistent disease. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World".

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Section: Clinical Presentation Of Chikungunya In Human: More Than a Bmentioning

confidence: 82%

Section: Adaptive Immunity To Chikv Infectionmentioning

confidence: 99%

Chikungunya virus pathogenesis: From bedside to bench

Couderc

Lecuit

2015

Antiviral Research

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“…Other less common symptoms include neuropathy, cerebral disorder, neurosensory deficiency, burning mouth syndrome, paresthesia, cubital tunnel syndrome, gastrointestinal disorders, exanthema, pruritus, bursitis, and synovitis 28,36,44,[47][48][49] .…”

Section: Chronic Phasementioning

confidence: 99%

Chikungunya: Molecular Aspects, Clinical Outcomes and Pathogenesis

Bautista-Reyes

Núñez-Avellaneda

Alonso-Palomares

et al. 2017

RIC

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The alarming worldwide emergence of the chikungunya virus began in the last decade. Since the first autochthonous transmission in Mexico in November of 2014, the virus has spread throughout the country, resulted in multiple outbreaks. This virus produces an acute and self-limiting disease characterized by fever, polyarthralgia, myalgia, exanthema, and general malaise. It is transmitted to humans by the bite of Aedes aegypti and A. albopictus mosquitoes. The fact that the clinical presentation is similar to that produced by other arboviruses complicates its clinical diagnosis. The chronic stage of the disease can cause severe consequences lasting months or years, from local arthralgia to rheumatoid arthritis. In this review, we emphasize the public health threat posed by this highly disabling emerging disease, the clinical outcomes, and its possible physiopathological process. We outline the diagnosis and the impact that this virus has had in Mexico since its introduction.

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“…As a result, CHIKV has spread to new regions where dengue virus (DENV) is endemic, including, since December 2013, tropical and subtropical regions of the Western Hemisphere [2]. This has created a new challenge for health care systems that care for patients living in or returning from affected areas, as the clinical presentation of dengue and chikungunya overlap significantly [3–6]. The differentiation of infections with DENV and CHIKV is important not only for epidemiologic surveillance but also for clinical care, such as initiating appropriate management and providing prognostic information.…”

Section: Introductionmentioning

confidence: 99%

“…The differentiation of infections with DENV and CHIKV is important not only for epidemiologic surveillance but also for clinical care, such as initiating appropriate management and providing prognostic information. While certain clinical and laboratory findings have been associated with dengue (thrombocytopenia, leukopenia) or chikungunya (arthralgia/arthritis), these are not sufficiently accurate to determine the cause of illness in all cases without specific testing [3–6]. …”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of a single-reaction real-time RT-PCR for pan-dengue and chikungunya virus detection

Waggoner

Ballesteros²,

Gresh

et al. 2016

Journal of Clinical Virology

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Background Dengue virus (DENV) and chikungunya virus (CHIKV) now co-circulate throughout tropical regions of the world, with billions of people living at risk of infection. The differentiation of these infections is important for epidemiologic surveillance as well as clinical care, though widely-used molecular diagnostics for DENV and CHIKV require the performance of two to four separate PCR reactions for detection. Objectives In the current study, we sought to develop and evaluate a single-reaction, multiplex real-time RT-PCR (rRT-PCR) for the detection and differentiation of DENV and CHIKV (the pan-DENV–CHIKV rRT-PCR). Study design From an alignment of all available CHIKV complete genome sequences in GenBank, a new CHIKV rRT-PCR was designed for use in multiplex with a previously described assay for pan-DENV detection. Analytical evaluation was performed in accordance with published recommendations, and the pan-DENV–CHIKV rRT-PCR was clinically compared to reference molecular diagnostics for DENV and CHIKV using 182 serum samples from suspected cases in Managua, Nicaragua. Results The pan-DENV–CHIKV rRT-PCR had a dynamic range extending from 7.0 to 2.0 log10 copies/μL for each DENV serotype and CHIKV, and the lower limits of 95% detection were 7.9–37.4 copies/μL. The pan-DENV–CHIKV rRT-PCR detected DENV in 81 patients compared to 75 using a reference, hemi-nested DENV RT-PCR, and it demonstrated perfect agreement with a reference CHIKV rRT-PCR (54 positive samples). Conclusions The single-reaction, multiplex format of the pan-DENV–CHIKV rRT-PCR, combined with sensitive detection of both viruses, has the potential to improve detection while decreasing testing costs and streamlining molecular workflow.

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Chikungunya infection in Malaysia: Comparison with dengue infection in adults and predictors of persistent arthralgia

Cited by 64 publications

References 27 publications

Chikungunya virus pathogenesis: From bedside to bench

Chikungunya virus pathogenesis: From bedside to bench

Chikungunya: Molecular Aspects, Clinical Outcomes and Pathogenesis

Clinical evaluation of a single-reaction real-time RT-PCR for pan-dengue and chikungunya virus detection

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