Chikungunya and respiratory viral infections

Sankari, T.; Hoti, S.L.; Govindaraj, V; Das, Piyush R.

doi:10.1016/s1473-3099(07)70295-5

Cited by 15 publications

(13 citation statements)

References 6 publications

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“…A recent report from south India indicated that chikungunya-affected patients were more frequently coinfected by respiratory viruses than chikungunya disease-free subjects [8]. However, no clinical data were described in this study, and chikungunya was not reported to induce any respiratory symptoms.…”

contrasting

confidence: 61%

Acute chikungunya virus infection and asthma

Paganin¹,

Tasset²,

Poubeau³

et al. 2010

European Respiratory Journal

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contrasting

confidence: 61%

Acute chikungunya virus infection and asthma

Paganin¹,

Tasset²,

Poubeau³

et al. 2010

European Respiratory Journal

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“…It has already been established from clinical cohort studies that age is a critical factor linked to more severe CHIKV pathologies and long-term sequelae (11,19,20,41). Of critical note, severe cases reported from hospitalized cohorts may be related to diverse underlying medical conditions, most commonly with hypertension, respiratory conditions, and diabetes mellitus (11,12,20,41,42). Our study was also from a cohort of hospitalized patients, but we compared two groups where diabetes type II (the only reported comorbidity) was equally found.…”

Section: Discussionmentioning

confidence: 99%

Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

Hoarau

Bandjee

Krejbich-Trotot

et al. 2010

The Journal of Immunology

500

671

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International audienceAlphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses of the clinical and immunological parameters throughout the disease course were analyzed in either the “recovered” or the “chronic” groups to identify prognostic markers of arthritis-like pathology after CHIKV disease. We found that the chronic group consisted mainly of more elderly patients (\textgreater60 y) and with much higher viral loads (up to 1010 viruses per milliliter of blood) during the acute phase. Remarkably, a rapid innate immune antiviral response was demonstrated by robust dendritic/NK/CD4/CD8 cell activation and accompanied by a rather weak Th1/Th2 cytokine response in both groups. Interestingly, the antiviral immune response witnessed by high levels of IFN-α mRNA in PBMCs and circulating IL-12 persisted for months only in the chronic group. CHIKV (RNA and proteins) was found in perivascular synovial macrophages in one chronic patient 18 mo postinfection surrounded by infiltrating NK and T cells (CD4++ but rare cytotoxic CD8). Fibroblast hyperplasia, strong angiogenesis, tissue lesions given the high levels of matrix metalloproteinase 2, and acute cell death [high cleaved poly(ADP-ribose) polymerase staining] were observed in the injured synovial tissue. These observed cellular and molecular events may contribute to chronic arthralgia/arthritis targeted by methotrexate used empirically for effective treatment but with immunosuppressive function in a context of viral persistence

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“…In La Réunion Island during 2005–2006, Lemant and colleagues reported two patients over the age of 60 with laboratory-confirmed CHIKF who were initially diagnosed with pneumonia caused by Streptococcus pneumoniae and Candida albicans , respectively [39]. Additionally, in a sample of cases from a 2006–2007 outbreak in Pondicherry and Karaikal, India, 87% of laboratory-confirmed CHIKF patients were co-infected with respiratory syncytial virus (RSV) [42], and 9% were also infected with adenoviruses; just 4% of CHIKF cases were mono-infected with CHIKV. Curiously, only CHIKV(+) cases were co-infected with multiple respiratory viruses.…”

Section: Discussionmentioning

confidence: 99%

Molecular Virologic and Clinical Characteristics of a Chikungunya Fever Outbreak in La Romana, Dominican Republic, 2014

et al. 2016

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Since emerging in Saint Martin in 2013, chikungunya virus (CHIKV), an alphavirus transmitted by the Aedes aegypti mosquito, has infected approximately two million individuals in the Americas, with over 500,000 reported cases in the Dominican Republic (DR). CHIKV-infected patients typically present with a febrile syndrome including polyarthritis/polyarthralgia, and a macropapular rash, similar to those infected with dengue and Zika viruses, and malaria. Nevertheless, many Dominican cases are unconfirmed due to the unavailability and high cost of laboratory testing and the absence of specific treatment for CHIKV infection. To obtain a more accurate representation of chikungunya fever (CHIKF) clinical signs and symptoms, and confirm the viral lineage responsible for the DR CHIKV outbreak, we tested 194 serum samples for CHIKV RNA and IgM antibodies from patients seen in a hospital in La Romana, DR using quantitative RT-PCR and IgM capture ELISA, and performed retrospective chart reviews. RNA and antibodies were detected in 49% and 24.7% of participants, respectively. Sequencing revealed that the CHIKV strain responsible for the La Romana outbreak belonged to the Asian/American lineage and grouped phylogenetically with recent Mexican and Trinidadian isolates. Our study shows that, while CHIKV-infected individuals were infrequently diagnosed with CHIKF, uninfected patients were never falsely diagnosed with CHIKF. Participants testing positive for CHIKV RNA were more likely to present with arthralgia, although it was reported in just 20.0% of CHIKF+ individuals. High percentages of respiratory (19.6%) signs and symptoms, especially among children, were noted, though it was not possible to determine whether individuals infected with CHIKV were co-infected with other pathogens. These results suggest that CHIKV may have been underdiagnosed during this outbreak, and that CHIKF should be included in differential diagnoses of diverse undifferentiated febrile syndromes in the Americas.

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Chikungunya and respiratory viral infections

Cited by 15 publications

References 6 publications

Acute chikungunya virus infection and asthma

Acute chikungunya virus infection and asthma

Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

Molecular Virologic and Clinical Characteristics of a Chikungunya Fever Outbreak in La Romana, Dominican Republic, 2014

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