Chikungunya and Dengue Fever among Hospitalized Febrile Patients in Northern Tanzania

Hertz, Julian T.; Munishi, O. Michael; Ooi, Eng Eong; Howe, Shiqin; Lim, Wen Yan; Chow, Angelia; Morrissey, Anne B.; Bartlett, John A.; Onyango, Jecinta J.; Maro, Venance P.; Kinabo, Grace D.; Saganda, Wilbrod; Gubler, Duane J.; Crump, John A.

doi:10.4269/ajtmh.2012.11-0393

Cited by 117 publications

(138 citation statements)

References 39 publications

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“…This is in line with recent findings from Tanzania indicating that CHIKV mainly circulates in children during endemicity periods. 8 Although our study was not designed to validate diagnostic kits for the detection of specific antibodies against CHIKV, we observed that, in 94.5% of samples, a positive result by CHIKV IgG ELISA and CHIKV IgG IIFA was confirmed by MNTA, indicating a good specificity of the combination of these commercial methods. Conversely, all 18 samples that tested IgM-positive against CHIKV by ELISA were judged as false positive when evaluated by CHIKV IgM IIFA and MNTA, suggesting a poor performance in terms of specificity for the ELISA IgM kit.…”

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confidence: 80%

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Bacci¹,

Marchi²,

Fiévet³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to investigate the seroprevalence of antichikungunya virus (anti-CHIKV) antibodies in pregnant women living in an urban area of Benin (West Africa). Results were obtained by screening sera collected in 2006 and 2007 with enzyme-linked immunosorbent assay (ELISA) for anti-CHIKV immunoglobulin G (IgG) and IgM. Positive results were confirmed by indirect immunofluorescence test and microneutralization assay. We found that a large proportion (36.1%) of pregnant women living in Cotonou had specific IgG against CHIKV, indicating a high seroprevalence of the infection in urban southern Benin, whereas no active cases of CHIKV infection were detected.Arboviruses that are transmitted by Aedes mosquitoes, such as dengue virus and chikungunya virus (CHIKV) infections, are a global threat because of their rapid and abrupt spread worldwide and the infection-related disease burden.

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mentioning

confidence: 80%

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Bacci¹,

Marchi²,

Fiévet³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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“…Although dengue is recognized as a significant public health problem in the AsiaPacific and Americas-Caribbean regions, it is underrecognized and underreported in Africa. 16 As Aedes species are found widely throughout much of Africa, and given rapid population growth and unplanned urbanization, potential for DENV transmission in Africa is substantial. 17,18 Recent global estimates indicate that Africa's dengue burden is nearly equivalent to that of the Americas.…”

Section: Resultsmentioning

confidence: 99%

Dengue Virus Seroconversion in Travelers to Dengue-Endemic Areas

Olivero

Hamer

Macleod

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. We conducted a prospective study to measure dengue virus (DENV) antibody seroconversion in travelers to dengue-endemic areas. Travelers seen in the Boston Area Travel Medicine Network planning to visit dengueendemic countries for ≥ 2 weeks were enrolled from 2009 to 2010. Pre-and post-travel blood samples and questionnaires were collected. Post-travel sera were tested for anti-DENV IgG by indirect IgG enzyme-linked immunosorbent assay (ELISA) and anti-DENV IgM by capture IgM ELISA. Participants with positive post-travel anti-DENV IgG or IgM were tested for pre-travel anti-DENV IgG and IgM; they were excluded from the seroconversion calculation if either pre-travel anti-DENV IgG or IgM were positive. Paired sera and questionnaires were collected for 62% (589/955) of enrolled travelers. Most participants were 19-64 years of age, female, and white. The most common purposes of travel were tourism and visiting friends and relatives; most trips were to Asia or Africa. Median length of travel was 21 days. DENV antibody seroconversion by either anti-DENV IgM or IgG ELISA was 2.9-6.8%; lower range percent excluded potential false-positive anti-DENV IgG due to receipt of yellow fever or Japanese encephalitis vaccines at enrollment; upper range percent excluded proven false-positive anti-DENV IgM. Eighteen percent of those with seroconversion reported dengue-like symptoms. Seroconversion was documented for travel to Africa as well as countries and regions known to be highly dengue endemic (India, Brazil, southeast Asia). Given widespread risk of dengue, travel medicine counseling should include information on risk of dengue in endemic areas and advice on preventing insect bites and seeking prompt medical attention for febrile illness. BACKGROUND

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“…Also, intestinal sickness should have been over-analyzed in various parts of Tanzania [25][26][27], mostly because of absence of differential pathogen analysis separated from jungle fever [28], including dengue and Chikungunya. Late examinations in Tanzania have uncovered that patients with intense dengue and Chikungunya disease are frequently misdiagnosed and treated with hostile to malarial or anti-microbial [29,30]. The advancement of medication safe intestinal sickness strains (due to over-recommending of anti malarial [31].…”

Section: Discussionmentioning

confidence: 99%

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2017

JHVRV

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The age group of 14 years to 69 was enrolled. The symptoms and duration and intensity of fever were systemically classified for the study. The only viral fever patients were included. AbstractIntroduction: Acute viral infection belong to the group of arthropod .Chikungunya fever now a days is spreading worldwide and some recent studies shown the different t features and most clinical features is topic of inertest is bony pain, which is the most severe form . Chikungunya fever is going to be the increasing number in the financially and economical burden. MethodologySample size: Total number of total patients was 245 in our study.Study design: Cohort study, systemically all patients were enrolled. Inclusion criteria:The age group of 14 years to 69 was enrolled. The symptoms and duration and intensity of fever were systemically classified for the study. Only viral fever patients were included. Exclusion criteria:The age group less than 13 and more than 70 years were excluded. Fever other than viral not included. Known case of any joint deformity and joint disease were excluded. The patients already using different types of painkillers prior to the disease for any systemic disease were not included. Data entry: SPSS 22 used for data entry.Result: A total 245 patients with duration of six month were selected for the study. We enrolled patients within six month period time. Total of patients visiting the hospital of age group of 14 age to 60 plus Conclusion: Fever of the patients were include both low grade and high grade, Most patient were having no symptoms except fever while rest, 38 patients having diarrhea, and 36 patients having vomiting 24 patients had flu like symptoms, flushing in 18 patients noticed and 18 patients having multiple presentations. The duration of the patients with the symptoms last for one week to three months. Most of them responded and get bettered with first 3 weeks and responded to acetaminophen.

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Chikungunya and Dengue Fever among Hospitalized Febrile Patients in Northern Tanzania

Cited by 117 publications

References 39 publications

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Dengue Virus Seroconversion in Travelers to Dengue-Endemic Areas

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