Chikungunya - a serious threat for public health

Hrnjakovic-Cvjetkovic, B Ivana; Cvjetković, Dejan; Patić, Aleksandra; Nikolić, Nataša; Stefan-Mikić, Sandra; Milosevic, Vesna

doi:10.2298/mpns1504122h

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…Mosquito-borne arboviruses constitute an important proportion of emerging infectious diseases that are a global threat to the human and animal populations [1–5]. About 167/300 (55.7 %) of the viruses in ‘The Arthropod-borne viruses of vertebrates’, a book that gives an account of the activities of the Rockefeller Foundation program were listed as transmitted by mosquitoes [6].…”

Section: Introductionmentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

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Mosquito-transmitted arboviruses constitute a large proportion of emerging infectious diseases that are both a public health problem and a threat to animal populations. Many such viruses were identified in East Africa, a region where they remain important and from where new arboviruses may emerge. We set out to describe and review the relevant mosquito-borne viruses that have been identified specifically in Uganda. We focused on the discovery, burden, mode of transmission, animal hosts and clinical manifestation of those previously involved in disease outbreaks. A search for mosquito-borne arboviruses detected in Uganda was conducted using search terms ‘Arboviruses in Uganda’ and ‘Mosquitoes and Viruses in Uganda’ in PubMed and Google Scholar in 2020. Twenty-four mosquito-borne viruses from different animal hosts, humans and mosquitoes were documented. The majority of these were from family Peribunyaviridae, followed by Flaviviridae, Togaviridae, Phenuiviridae and only one each from family Rhabdoviridae and Reoviridae. Sixteen (66.7 %) of the viruses were associated with febrile illnesses. Ten (41.7 %) of them were first described locally in Uganda. Six of these are a public threat as they have been previously associated with disease outbreaks either within or outside Uganda. Historically, there is a high burden and endemicity of arboviruses in Uganda. Given the many diverse mosquito species known in the country, there is also a likelihood of many undescribed mosquito-borne viruses. New generation diagnostic platforms have great potential to identify new viruses. Indeed, four novel viruses, two of which were from humans (Ntwetwe and Nyangole viruses) and two from mosquitoes (Kibale and Mburo viruses) including the 2010 yellow fever virus (YFV) outbreak were identified in the last decade using next generation sequencing. Given the unbiased approach of detection of viruses by this technology, its use will undoubtedly be critically important in the characterization of mosquito viromes which in turn will inform other diagnostic efforts.

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Section: Introductionmentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

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“…Chikungunya, a Makonde term meaning "that which bends up" [23], is an acute illness similar to dengue that is characterized by the abrupt onset of high-grade fever, followed by constitutional symptoms such as polyarthritis, musculoskeletal pain, headache, and skin involvement [24], and in rare cases by severe manifestations such as encephalopathy [21,24], acute hepatitis [25,26], myocarditis [27][28][29], and multi-organ failure. The acute phase (viremic period) lasts from 5 to 10 days on average, and is resolved within a few weeks.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study

et al. 2020

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Background The chikungunya virus (CHIKV) is a re-emerging alphavirus that can cause chronic and potentially incapacitating rheumatic musculoskeletal disorders known as chronic chikungunya arthritis (CCA). We conducted a prospective cohort study of CHIKV-infected subjects during the 2013 chikungunya outbreak in Martinique. The aim of this study was to assess the prevalence of CCA at 12 months and to search for acute phase factors significantly associated with chronicity. Methodology/Principal findings A total of 193 patients who tested positive for CHIKV RNA via qRT-PCR underwent clinical investigations in the acute phase (<21 days), and then 3, 6, and 12 months after inclusion. The Asian lineage was identified as the circulating genotype. A total of 167 participants were classified as either with or without CCA, and were analyzed using logistic regression models. The overall prevalence of CCA at 12 months was 52.1% (95%CI: 44.5-59.7). In

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“…Female Aedes aegypti mosquitoes are responsible for the propagation of diseases of public health significance: yellow fever, dengue, chikungunya, and Zika virus (1)(2)(3)(4)(5)(6). The unfortunate convergence of a lack of vaccines for dengue, chikungunya, and Zika viruses, the increase of global disease distribution due to climate change (7)(8)(9), and an increase in travel clearly demand better mosquito vector control strategies.…”

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confidence: 99%

“…During blood meal digestion, only a small percentage of amino acids is retained for follicle development and maternal reserves, whereas the majority of amino acids are oxidized for metabolic needs and excreted as CO 2 or other waste (10,11). One of the by-products of blood digestion is ammonia, defined here as NH 3 , NH 4 + , or a combination of both. Previous studies have demonstrated that Ae.…”

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confidence: 99%

Xanthine dehydrogenase‐1 silencing in Aedes aegypti mosquitoes promotes a blood feeding–induced adulticidal activity

et al. 2017

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has 2 genes encoding xanthine dehydrogenase (XDH). We analyzed and gene expression by real-time quantitative PCR in tissues from sugar- and blood-fed females. Differential and gene expression was observed in tissues dissected throughout a time course. We next exposed females to blood meals supplemented with allopurinol, a well-characterized XDH inhibitor. We also tested the effects of injecting double-stranded RNA (dsRNA) against XDH1, XDH2, or both. Disruption of XDH by allopurinol or XDH1 by RNA interference significantly affected mosquito survival, causing a disruption in blood digestion, excretion, oviposition, and reproduction. XDH1-deficient mosquitoes showed a persistence of serine proteases in the midgut at 48 h after blood feeding and a reduction in the uptake of vitellogenin by the ovaries. Surprisingly, analysis of the fat body from dsRNA-XDH1-injected mosquitoes fell into 2 groups: one group was characterized by a reduction of the XDH1 transcript, whereas the other group was characterized by an up-regulation of several transcripts, including XDH1, glutamine synthetase, alanine aminotransferase, catalase, superoxide dismutase, ornithine decarboxylase, glutamate receptor, and ammonia transporter. Our data demonstrate that XDH1 plays an essential role and that XDH1 has the potential to be used as a metabolic target for vector control.-Isoe, J., Petchampai, N., Isoe, Y. E., Co, K., Mazzalupo, S., Scaraffia, P. Y. Xanthine dehydrogenase-1 silencing in mosquitoes promotes a blood feeding-induced adulticidal activity.

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Chikungunya - a serious threat for public health

Abstract: Fast developing international traffic and booming tourism as well as the vector spreading from its homeland make chikungunya a real threat to our country.

Cited by 8 publications

References 13 publications

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique): A prospective cohort study

Xanthine dehydrogenase‐1 silencing in Aedes aegypti mosquitoes promotes a blood feeding–induced adulticidal activity

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