Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail

Bian, Meng; Wang, Juan; Wang, Yu; Nie, Anzheng; Zhu, Chunsheng; Sun, Zongxi; Zhou, Zheng; Zhang, Bing

doi:10.1016/j.biopha.2020.110719

Cited by 74 publications

(65 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genus Bifidobacterium can inhibit the growth of harmful bacteria, resist pathogen infection, synthesize vitamins needed by the human body, promote the absorption of minerals, produce acetic acid, acetic acid propiononic acid, butyric acid and lactic acid to stimulate intestinal peristalsis, promote defecation, prevent constipation and inhibit intestinal corruption, purify the intestinal environment, decompose carcinogens, and stimulate the human immune system to improve disease resistance. In this study, the abundance of the genus Bifidobacterium in the population of the AH was very low, and this result is consistent with previous studies [ 28 ]. This result suggests that there is flora imbalance in the AH population.…”

Section: Discussionsupporting

confidence: 93%

Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

et al. 2021

View full text Add to dashboard Cite

Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH.

show abstract

Section: Discussionsupporting

confidence: 93%

Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Serum creatinine (SCr) is an endogenous creatinine filtered by glomerulus. Like BUN, the change of SCr content is also an important indicator of renal function [ 47 ]. When renal function is damaged, the level of SCr will increase [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…When glomerular filtration ability decreased to a certain degree, BUN level tends to increase [46]. Serum creatinine (SCr) is an endogenous [47]. When renal function is damaged, the level of SCr will increase [48].…”

mentioning

confidence: 99%

Inflammatory Response and Oxidative Stress as Mechanism of Reducing Hyperuricemia of Gardenia jasminoides‐Poria cocos with Network Pharmacology

Liu

Jiang

Liu

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Hyperuricemia (HUA) is a metabolic disease, closely related to oxidative stress and inflammatory responses, caused by reduced excretion or increased production of uric acid. However, the existing therapeutic drugs have many side effects. It is imperative to find a drug or an alternative medicine to effectively control HUA. It was reported that Gardenia jasminoides and Poria cocos could reduce the level of uric acid in hyperuricemic rats through the inhibition of xanthine oxidase (XOD) activity. But there were few studies on its mechanism. Therefore, the effective ingredients in G. jasminoides and P. cocoa extracts (GPE), the active target sites, and the further potential mechanisms were studied by LC-/MS/MS, molecular docking, and network pharmacology, combined with the validation of animal experiments. These results proved that GPE could significantly improve HUA induced by potassium oxazine with the characteristics of multicomponent, multitarget, and multichannel overall regulation. In general, GPE could reduce the level of uric acid and alleviate liver and kidney injury caused by inflammatory response and oxidative stress. The mechanism might be related to the TNF-α and IL-7 signaling pathway.

show abstract

“…In addition, GF mice model further provided strong evidence for the causative role of LPS in NAFLD development, as indicated by that only simultaneous high-fat diet administration and endotoxin-producing pathobiont mono-association induce NAFLD ( Fei et al., 2020 ). The administration of gut commensal microbes, such as A. muciniphila and Roseburia intestinalis , and the modulation of gut microbiota via certain natural substances induced improved gut barrier function and attenuated LPS-associated systemic inflammation, consequently improving related systemic diseases ( Cani et al., 2009 ; Jiang et al., 2016 ; Li J. et al., 2016 ; Song et al., 2016 ; Kasahara et al., 2018 ; Bian et al., 2020 ). In addition to paracellular pathway, LPS can translocate gut barrier in transcellular way via the phagocytosis of enterocyte mediated by toll-like receptor 4 (TLR4) ( Neal et al., 2006 ).…”

Section: Underlying Mechanisms Of Gut-alveolar Bone Axismentioning

confidence: 99%

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.

show abstract

Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail

Cited by 74 publications

References 47 publications

Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

Inflammatory Response and Oxidative Stress as Mechanism of Reducing Hyperuricemia of Gardenia jasminoides‐Poria cocos with Network Pharmacology

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Contact Info

Product

Resources

About