Chicken parvovirus and its associations with malabsorption syndrome

Finkler, Fabrine; Lima, Diane Alves de; Cerva, Cristine; Moraes, Lucas Brunelli de; Cibulski, Samuel Paulo; Teixeira, Thaís Fumaco; Santos, Helton Fernandes dos; Almeida, Laura Lopes de; Roehe, Paulo Michel; Franco, Ana Cláudia

doi:10.1016/j.rvsc.2016.06.001

Cited by 8 publications

(13 citation statements)

References 10 publications

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“…The detection of ChPV in poultry at 1 wk of age is not surprising, as published studies suggested the possibility of vertical viral transmission ( 26 , 27 ). However, we demonstrated the absence of parvovirus in cloacal swabs from 1- to 5-day-old broiler chickens, which was different from Finkler's report ( 28 ), and this finding may be due to the different pathogenicity of the virus strains or the different chicken breeds. In our study, parvovirus was detected mainly in healthy birds.…”

Section: Discussioncontrasting

confidence: 99%

Epidemiological Surveillance of Parvoviruses in Commercial Chicken and Turkey Farms in Guangxi, Southern China, During 2014–2019

et al. 2020

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A previously unidentified chicken parvovirus (ChPV) and turkey parvovirus (TuPV) strain, associated with runting-stunting syndrome (RSS) and poultry enteritis and mortality syndrome (PEMS) in turkeys, is now prevalent among chickens in China. In this study, a large-scale surveillance of parvoviruses in chickens and turkeys using conserved PCR assays was performed. We assessed the prevalence of ChPV/TuPV in commercial chicken and turkey farms in China between 2014 and 2019. Parvoviruses were prevalent in 51.73% (1,795/3,470) of commercial chicken and turkey farms in Guangxi, China. The highest frequency of ChPV positive samples tested by PCR occurred in chickens that were broiler chickens 64.18% (1,041/1,622) compared with breeder chickens 38.75% (572/1,476) and layer hens 38.89% (112/288), and TuPV was detected in 70/84 (83.33%). Native and exotic chicken species were both prevalent in commercial farms in southern China, and exotic broiler chickens had a higher positive rate with 88.10% (148/168), while native chickens were 50.00% (1,465/2,930). The environmental samples from poultry houses tested positive for ChPV and TuPV were 47.05% (415/874). Samples from open house flocks had higher prevalence rates of ChPV than those of closed house flocks ( Table 5 ), among which those from the open house showed 84.16% (85/101) positivity, those from litter showed 62.86% (44/70) positivity, and those from drinking water showed 50.00% (56/112) positivity, whereas those from the closed house litter were 53.57% (60/112), those from swabs were 50.18% (138/275), and those from drinking water were 15.69% (32/204). Samples collected during spring were more frequently ChPV/ TuPV positive than those collected during other seasons. This study is the first report regarding the epidemiological surveillance of ChPV and TuPV in chicken/turkey flocks in Guangxi, China. Our results suggest that ChPV and TuPV are widely distributed in commercial fowl in Guangxi. These findings highlight the need for further epidemiological and genetic research on ChPV and TuPV in this area.

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Section: Discussioncontrasting

confidence: 99%

Epidemiological Surveillance of Parvoviruses in Commercial Chicken and Turkey Farms in Guangxi, Southern China, During 2014–2019

et al. 2020

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“…The parvovirus-specific nuclear staining was observed in epithelial cells and inflammatory cells from small intestine in both chicken and turkey samples (Kisary, 1985;Zsak et al, 2013). Moreover, among all tissues, the intestines of affected birds contained the highest parvoviral loads (Finkler et al, 2016). Altogether, these findings suggested that enterocytes of the small intestine and the local inflammatory cells are the primary target cells for parvovirus Zsak et al, 2013;Nuñez et al, 2016).…”

Section: Clinical Features Pathology and Pathogenesismentioning

confidence: 81%

“…The ChPV genome distribution has been detected in BF and spleen Finkler et al, 2016). As lymphoid organs, cells in these organs also multiply actively and may be prone to infection by parvoviruses (Finkler et al, 2016). Parvovirus has also been detected in the liver, exocrine and pancreas.…”

Section: Clinical Features Pathology and Pathogenesismentioning

confidence: 99%

“…Parvovirus has also been detected in the liver, exocrine and pancreas. Detection of parvovirus in several tissues could be due to the generalization of infection from the replication site Finkler et al, 2016).…”

Section: Clinical Features Pathology and Pathogenesismentioning

confidence: 99%

“…The non-invasive real-time PCR assays have been developed for detection and quantitation of ChPV from faecal samples (Spatz et al, 2015). Recently, a qPCR has been applied to establish correlations between ChPV genome loads and the occurrence of malabsorption syndrome (Finkler et al, 2016). A PCR followed by restriction fragment length polymorphism and DNA sequencing has been used for differentiation of poultry parvoviruses of TuPV, ChPV and divergent, TuPV-like ChPV strains.…”

Section: Diagnosismentioning

confidence: 99%

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Avian parvovirus: classification, phylogeny, pathogenesis and diagnosis

et al. 2018

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Poultry parvoviruses identified during the early 1980s are found worldwide in intestines from young birds with enteric disease syndromes as well as healthy birds. The chicken parvovirus (ChPV) and turkey parvovirus (TuPV) belong to the Aveparvovirus genus within the subfamily Parvovirinae. Poultry parvoviruses are small, non-enveloped, single-stranded DNA viruses consisting of three open reading frames, the first two encoding the non-structural protein (NS) and nuclear phosphoprotein (NP) and the third encoding the viral capsid proteins 1 (VP1 and VP2). In contrast to other parvoviruses, the VP1-unique region does not contain the phospholipase A2 sequence motif. Recent experimental studies suggested the parvoviruses to be the candidate pathogens in cases of enteric disease syndrome. Current diagnostic methods for poultry parvovirus detection include PCR, real-time PCR, enzyme linked immunosorbent assay using recombinant VP2 or VP1 capsid proteins. Moreover, sequenceindependent amplification techniques combined with next-generation sequencing platforms have allowed rapid and simultaneous detection of the parvovirus from affected and healthy birds. There is no commercial vaccine; hence, the development of an effective vaccine to control the spread of infection should be of primary importance. This review presents the current knowledge on poultry parvoviruses with emphasis on taxonomy, phylogenetic relationship, genomic analysis, epidemiology, pathogenesis and diagnostic methods. ARTICLE HISTORY

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