Chicken GLUT4 undergoes complex alternative splicing events and its expression in striated muscle changes dramatically during development

Luo, Pengna; Wang, Ziyang; Su, Chuanchen; Li, Huihong; Zhang, Huaiyong; Huang, Yanqun; Chen, Wen

doi:10.1016/j.psj.2022.102403

Cited by 3 publications

(3 citation statements)

References 62 publications

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“…GLUT-4 transporter in birds [75,76], while others claim to have detected it [77,78]. One hypothesis to explain these conflicting results might be because avian genomes remain incompletely annotated owing to complexity.…”

Section: (A) Fast and Effective Glucose Utilization: The Case Of Flyi...mentioning

confidence: 99%

“…While the insulin-dependent cascade is conserved across most vertebrates [ 73 ], it differs substantially in birds [ 74 ]. Indeed, mammals heavily rely on GLUT-4 for insulin-induced glucose uptake into cells, but some studies mention the absence of the GLUT-4 transporter in birds [ 75 , 76 ], while others claim to have detected it [ 77 , 78 ]. One hypothesis to explain these conflicting results might be because avian genomes remain incompletely annotated owing to complexity.…”

Section: Mechanisms Of Glycation Resistance That Need To Be Explored ...mentioning

confidence: 99%

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Glycation resistance and life-history traits: lessons from non-conventional animal models

Duval,

Criscuolo,

Bertile

2024

Biol. Lett.

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Glycation reactions play a key role in the senescence process and are involved in numerous age-related pathologies, such as diabetes complications or Alzheimer’s disease. As a result, past studies on glycation have mostly focused on human and laboratory animal models for medical purposes. Very little is known about glycation and its link to senescence in wild animal species. Yet, despite feeding on high-sugar diets, several bat and bird species are long-lived and seem to escape the toxic effects of high glycaemia. The study of these models could open new avenues both for understanding the mechanisms that coevolved with glycation resistance and for treating the damaging effects of glycations in humans. Our understanding of glycaemia’s correlation to proxies of animals’ pace of life is emerging in few wild species; however, virtually nothing is known about their resistance to glycation, nor on the relationship between glycation, species’ life-history traits and individual fitness. Our review summarizes the scarce current knowledge on the links between glycation and life-history traits in non-conventional animal models, highlighting the predominance of avian research. We also investigate some key molecular and physiological parameters involved in glycation regulation, which hold promise for future research on fitness and senescence of individuals.

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Section: (A) Fast and Effective Glucose Utilization: The Case Of Flyi...mentioning

confidence: 99%

Section: Mechanisms Of Glycation Resistance That Need To Be Explored ...mentioning

confidence: 99%

Glycation resistance and life-history traits: lessons from non-conventional animal models

Duval,

Criscuolo,

Bertile

2024

Biol. Lett.

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“…Although the ultimate causation of this phenomenon is largely unknown, recent studies have suggested that hyperglycemia and insulin resistance are related to the drop of oxygen concentrations in the atmosphere at the Permian–Triassic (PT) boundary, forcing theropods to lose certain genes to maximize their efficiency of oxygen usage (Satoh 2021). Indeed, omentin and insulin-sensitive glucose transporter 4 (GLUT4) are considered missing or unfunctional in the bird genome (Braun and Sweazea 2008, Luo et al 2023). Because these gene products play essential roles in maintaining insulin sensitivity, this loss probably forced theropods to become insulin resistant (Satoh 2021).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the plasma metabolome of migrating passerines during stopover: Novel insights into flight metabolism

Domer,

Jasinska,

Rosental

et al. 2024

Preprint

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During long distance migration, many birds may experience periods of either prolonged fasting, during endurance flights, or extensive feeding during stopovers. It was previously shown that habitat selection during stopover can largely affect the migration outcome of an individual. Despite decades of research of the avian metabolism during stopover and migration, many questions have remained unanswered, as such research mainly focused on targeted metabolites and fat metabolism. Here, we examined the plasma-metabolome of migrating passerines prior to their crossing the Sahara Desert. Birds were sampled at two sites populated by Pistacia trees, bearing fat-rich fruits, and at an additional site dominated by blooming Eucalyptus trees. The blood samples were analyzed using both GC-MS and LC-MS, using an untargeted approach. We found that birds from one of the sites had a distinguish metabolic profile, suggesting recent landing. Examination of metabolic pathways activated during stopovers indicated a crucial role for cycling glucose through the Cori and Cahill cycles in resting and recovery processes. This novel perspective, conducted on free-ranging birds, suggests the evolution of avian insulin resistance due to factors such as endurance exercise, fasting, and a preference for fatty acid oxidation during migration, akin to cell trauma recovery. Additionally, we investigated inter-site variations in birds' metabolic profiles. Significant variations were observed in both polar and lipophilic metabolites among the sites. Differences in polar metabolites were primarily attributed to variations in the physiological state of the birds between sites, while distinctions in the lipophilic profiles of rested birds were linked to variations in their primary food sources. This study underscores the challenge of interpreting commonly used indicators for assessing migrating birds' physiological states and site quality, which are predominantly derived from lipid metabolism, in complex ecological systems.

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Chicken GLUT4 function via enhancing mitochondrial oxidative phosphorylation and inhibiting ribosome pathway in skeletal muscle satellite cells

Zhang,

Luo,

et al. 2024

Poultry Science

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Chicken GLUT4 undergoes complex alternative splicing events and its expression in striated muscle changes dramatically during development

Cited by 3 publications

References 62 publications

Glycation resistance and life-history traits: lessons from non-conventional animal models

Glycation resistance and life-history traits: lessons from non-conventional animal models

Comparative analysis of the plasma metabolome of migrating passerines during stopover: Novel insights into flight metabolism

Chicken GLUT4 function via enhancing mitochondrial oxidative phosphorylation and inhibiting ribosome pathway in skeletal muscle satellite cells

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