Chicken Brain Amines: Normal Levels and Effect of Reserpine and Monoamine Oxidase Inhibitors

Pscheidt, G.R.; Himwich, Harold E.

doi:10.1016/s0079-6123(08)61404-1

Cited by 13 publications

(8 citation statements)

References 14 publications

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“…Corpus striation Although, according to Pscheidt and his co-workers, the corpus striatum contains high amounts of both CA and 5-HT (5,7,8), typical, varicose terminals and fibers were not detected in this study. This is presumably due to the presence of very fine terminals and fibers.…”

Section: Septal Areacontrasting

confidence: 65%

Distribution of Monoamine-Containing Terminals and Fibers in the Central Nervous System of the Chicken

Ikeda

Gotoh

1974

Japanese Journal of Pharmacology

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Section: Septal Areacontrasting

confidence: 65%

Distribution of Monoamine-Containing Terminals and Fibers in the Central Nervous System of the Chicken

Ikeda

Gotoh

1974

Japanese Journal of Pharmacology

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“…Benzylhydrazines are potent inhibitors of dopamine 3-hydroxylase in vitro and in vivo (Creveling, van der Schoot & Udenfriend, 1962;Kuntzman, Costa, Creveling, Hirsch & Brodie, 1962) so the soporific effects could be due to a prolonged action of dopamine although the inhibitory activity of mebanazine (a-methyl benzylhydrazine) on dopamine /3-hydroxylase is not known. Pretreatment with a monoamine oxidase inhibitor increases the concentration of noradrenaline in the chicken brain (Pscheidt & Himwich, 1965) possibly filling storage granules with noradrenaline so that excess noradrenaline, newly synthesized from dopamine, overflows from the neurone and is released as free noradrenaline instead of the deaminated metabolite.…”

Section: Discussionmentioning

confidence: 99%

Effects of catecholamines infused into the brain of young chickens

Marley

Stephenson

1970

British J Pharmacology

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Summary1. (-)-Noradrenaline, (-)-a-methylnoradrenaline and (-)-isoprenaline were infused into various brain regions of 12-21 day chicks. When infused into the hypothalamic area, but not the cerebral hemisphere or posterior mesencephalon, these amines produced behavioural sleep, lowered temperature and blood pressure and reduced oxygen consumption; electrocortical sleep activity usually ensued but this was not marked and frequently dissociation between electrocortical activity and behaviour occurred. After monoamine oxidase inhibition, which prolonged the action of noradrenaline, dopamine had similar effects.2. The effects of the catecholamines were prevented or substantially reduced by pretreatment with phenoxybenzamine given intravenously or into the hypothalamus but not by intravenous injection of propranolol. However, intrahypothalamic infusion of propranolol prevented the temperature, but not the behavioural effects of noradrenaline. The implications of this are discussed. 3. That the effects were similar but more intense, apart from electrocortical changes, and of longer duration than those seen after intravenous injection of catecholamines suggests that in young chicks these amines penetrate from the blood into the brain and elicit their effects through a localized region, presumably the hypothalamus.

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“…frog [10], chicken [9], monkey [11], mouse, rat and guinea pig [8,12], cat [7] and rabbit [8] after the administration of i. So far, however, no such examination of the human brain has apparently been accomplished.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Monoamine Oxidase in the Rat Brain Neurons Exerted by Isocarboxazid

Bartoníček¹

1967

Pharmacology

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Chicken Brain Amines: Normal Levels and Effect of Reserpine and Monoamine Oxidase Inhibitors

Cited by 13 publications

References 14 publications

Distribution of Monoamine-Containing Terminals and Fibers in the Central Nervous System of the Chicken

Distribution of Monoamine-Containing Terminals and Fibers in the Central Nervous System of the Chicken

Effects of catecholamines infused into the brain of young chickens

Inhibition of Monoamine Oxidase in the Rat Brain Neurons Exerted by Isocarboxazid

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