Chick subcutaneous and abdominal adipose tissue depots respond differently in lipolytic and adipogenic activity to α-melanocyte stimulating hormone (α-MSH)

Shipp, Steven L.; Wang, Guoqing; Cline, Mark A.; Gilbert, Elizabeth R.

doi:10.1016/j.cbpa.2017.04.013

Cited by 4 publications

(4 citation statements)

References 57 publications

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“…The concentration of plasma ACTH was about 12 pg/ml in hatched chicks ( Okur et al, 2022 ) and 7–18 pg/ml in three-week-old male chicks from our recent study ( Liu et al, 2022 ). There is little information on the circulating concentrations of chicken α-MSH, which is also known to be present in systemic circulation for regulating pigmentation ( Ling et al, 2003 ) or lipolytic activity ( Shipp et al, 2017 ) in different chicken tissues. The concentration of plasma α-MSH was about 3.1 ng/ml (1.86 nmol/l) in 4-day-old chicks ( Shipp et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…There is little information on the circulating concentrations of chicken α-MSH, which is also known to be present in systemic circulation for regulating pigmentation ( Ling et al, 2003 ) or lipolytic activity ( Shipp et al, 2017 ) in different chicken tissues. The concentration of plasma α-MSH was about 3.1 ng/ml (1.86 nmol/l) in 4-day-old chicks ( Shipp et al, 2017 ). It is unclear if circulating α-MSH is three orders of magnitude higher than circulating ACTH or if this is an artifact of limited investigations.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism

Zhang

Huang

et al. 2022

Front. Physiol.

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Melanocortin receptors (MC1R-MC5R) and their accessory proteins (MRAPs) are involved in a variety of physiological processes, including pigmentation, lipolysis, adrenal steroidogenesis, and immunology. However, the physiological roles of MC5R are rarely characterized in vertebrates, particularly in birds. In this work, we cloned the full-length cDNA of chicken MC5R and identified its core promoter region. Functional studies revealed that cMC5R was more sensitive to ACTH/α-MSH than β-MSH/γ-MSH, and was coupled to the cAMP/PKA signaling pathway. We demonstrated that MRAP2 decreased MC5R sensitivity to α-MSH, whereas MRAP1 did not have a similar effect, and that both MRAPs significantly reduced MC5R expression on the cell membrane surface. Transcriptome and qPCR data showed that both MRAP1 and MC5R were highly expressed in chicken liver. Additionally, we observed that ACTH might increase hepatic glucose production and decrease lipogenesis in primary hepatocytes, and dose-dependently downregulated the expression levels of ELOVL6 and THRSPA genes. These findings indicated that ACTH may act directly on hepatocytes to regulate glucolipid metabolism, which will help to understand the function of MC5R in avian.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism

Zhang

Huang

et al. 2022

Front. Physiol.

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“…The expression of MCRs in human adipocytes is also lower or absent in humans, different from rodents [ 143 ]. The function of MC5R in lipolysis has also been identified in chicken and sea bass [ 61 , 62 , 144 ].…”

Section: Mc5r Regulates Lipolysis and Re-esterificationmentioning

confidence: 99%

“…In peripheral tissues, MC5R is involved in exocrine and endocrine gland secretion [ 41 , 42 ], defense behavior [ 43 , 44 ], thermoregulation [ 41 ], inflammation [ 45 , 46 ], and immune response [ 47 , 48 , 49 , 50 ]. MC5R regulates energy metabolism in the liver, adipose tissue, and skeletal muscle of various species, such as humans [ 51 , 52 , 53 , 54 ], mice [ 51 , 55 , 56 , 57 , 58 , 59 , 60 ], chickens [ 61 ], and sea bass [ 62 ]. MC5R primarily regulates energy metabolism via adipocyte lipolysis and re-esterification, fatty acid oxidation, and glucose uptake [ 51 , 52 , 53 , 54 ].…”

Section: Introductionmentioning

confidence: 99%

Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

Hong

Tao

2022

IJMS

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As the most recent melanocortin receptor (MCR) identified, melanocortin-5 receptor (MC5R) has unique tissue expression patterns, pharmacological properties, and physiological functions. Different from the other four MCR subtypes, MC5R is widely distributed in both the central nervous system and peripheral tissues and is associated with multiple functions. MC5R in sebaceous and preputial glands regulates lipid production and sexual behavior, respectively. MC5R expressed in immune cells is involved in immunomodulation. Among the five MCRs, MC5R is the predominant subtype expressed in skeletal muscle and white adipose tissue, tissues critical for energy metabolism. Activated MC5R triggers lipid mobilization in adipocytes and glucose uptake in skeletal muscle. Therefore, MC5R is a potential target for treating patients with obesity and diabetes mellitus. Melanocortin-2 receptor accessory proteins can modulate the cell surface expression, dimerization, and pharmacology of MC5R. This minireview summarizes the molecular and pharmacological properties of MC5R and highlights the progress made on MC5R in energy metabolism. We poInt. out knowledge gaps that need to be explored in the future.

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Pituitary gland

Scanes

2022

Sturkie's Avian Physiology

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Chick subcutaneous and abdominal adipose tissue depots respond differently in lipolytic and adipogenic activity to α-melanocyte stimulating hormone (α-MSH)

Cited by 4 publications

References 57 publications

Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism

Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism

Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism

Pituitary gland

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