Chick midgut morphogenesis

Huycke, Tyler R.; Tabin, Clifford J.

doi:10.1387/ijdb.170325ct

Cited by 23 publications

(20 citation statements)

References 113 publications

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“…This relationship between the initial growth stretch and number of ridges was in agreement with actual intestinal morphogenesis (Shyer et al 2013;Huycke and Tabin 2018).…”

Section: Energy Landscape Of Luminal Folding Caused By Growth and Consupporting

confidence: 86%

“…As a realistic biological application, we applied the energy landscape approach to the morphogenesis of intestinal villus in vertebrates. In the initial stage of villus formation, the intestinal tube folds into longitudinal ridges with differential growth of the inner epithelial and mesenchymal layers, which is constrained by the outer circumferentially oriented muscle layer (Shyer et al 2013;Huycke and Tabin 2018). We performed FEAs for luminal folding of intestinal tube following previously reported analyses (Shyer et al 2013;Goriely 2017).…”

Section: Simulation Conditionsmentioning

confidence: 99%

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An energy landscape approach to understanding variety and robustness in tissue morphogenesis

Takeda

Kameo

Inoue

et al. 2019

Biomech Model Mechanobiol

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During morphogenesis in development, multicellular tissues deform by mechanical forces induced by spatiotemporally regulated cellular activities, such as cell proliferation and constriction. Various morphologies are formed because of various spatiotemporal combinations and sequences of multicellular activities. Despite its potential to variations, morphogenesis is a surprisingly robust process, in which qualitatively similar morphologies are reproducibly formed even under spatiotemporal fluctuation of multicellular activities. To understand these essential characteristics of tissue morphogenesis, which involves the coexistence of various morphologies and robustness of the morphogenetic process, in this study, we propose a novel approach to capture the overall view of morphogenesis from mechanical viewpoints. This approach will enable visualization of the energy landscape, which includes morphogenetic processes induced by admissible histories of cellular activities. This approach was applied to investigate the morphogenesis of a sheet-like tissue with curvature, where it deformed to a concave or convex morphology depending on the history of growth and constriction. Qualitatively different morphologies were produced by bifurcation of the valley in the energy landscape. The depth and steepness of the valley near the stable states represented the degree of robustness to fluctuations of multicellular activities. Furthermore, as a realistic example, we showed an application of this approach to luminal folding observed in the initial stage of intestinal villus formation. This approach will be helpful to understand the mechanism of how various morphologies are formed and how tissues reproducibly achieve specific morphologies.

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“…This relationship between the initial growth stretch and number of ridges was in agreement with actual intestinal morphogenesis (Shyer et al 2013;Huycke and Tabin 2018).…”

Section: Energy Landscape Of Luminal Folding Caused By Growth and Consupporting

confidence: 86%

Section: Simulation Conditionsmentioning

confidence: 99%

An energy landscape approach to understanding variety and robustness in tissue morphogenesis

Takeda

Kameo

Inoue

et al. 2019

Biomech Model Mechanobiol

View full text Add to dashboard Cite

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“…12 b). 120 , 121 ) It has been suggested that two types of cellular changes in and around the dorsal mesentery are responsible for this leftward tilt. 121 , 122 ) First, mesenchymal cells of the right half of the dorsal mesentery become dispersed, whereas those of the left half become compacted.…”

Section: Asymmetric Organogenesismentioning

confidence: 99%

Molecular and cellular basis of left–right asymmetry in vertebrates

Hamada

2020

Proc. Jpn. Acad., Ser. B

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Although the human body appears superficially symmetrical with regard to the left–right (L-R) axis, most visceral organs are asymmetric in terms of their size, shape, or position. Such morphological asymmetries of visceral organs, which are essential for their proper function, are under the control of a genetic pathway that operates in the developing embryo. In many vertebrates including mammals, the breaking of L-R symmetry occurs at a structure known as the L-R organizer (LRO) located at the midline of the developing embryo. This symmetry breaking is followed by transfer of an active form of the signaling molecule Nodal from the LRO to the lateral plate mesoderm (LPM) on the left side, which results in asymmetric expression of Nodal (a left-side determinant) in the left LPM. Finally, L-R asymmetric morphogenesis of visceral organs is induced by Nodal-Pitx2 signaling. This review will describe our current understanding of the mechanisms that underlie the generation of L-R asymmetry in vertebrates, with a focus on mice.

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“…The gastrointestinal tract is an essential system of organs for animal growth because it performs vital functions in nutrient digestion and absorption ( Huycke and Tabin, 2018 ). Although the development of the intestine, a precise and ordered process, occurs through incubation, the functional abilities do not begin to develop until amniotic fluid is orally consumed by the chick embryo during the late incubation period.…”

Section: Introductionmentioning

confidence: 99%

Effects of in ovo feeding of N-acetyl-L-glutamate on early intestinal development and growth performance in broiler chickens

et al. 2020

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The present study determined the effects of in ovo feeding ( IOF ) of N -acetyl- L -glutamate ( NAG ) on early intestinal development and growth performance of broilers. A total of 702 fertile broiler eggs were randomly divided into 3 treatments: 1) non-punctured control group, 2) saline-injected control group, and 3) NAG solution–injected group (1.5 mg/egg). At 17.5 D of incubation, 300 μL of each solution was injected into each egg of injected groups. Results indicated that the hatchability and healthy chicken rate were not affected by NAG injection ( P > 0.05). Chicks from NAG solution–injected group had significantly decreased average daily feed intake and feed conversion ratio during 1–14 D than those in the non-punctured control group ( P < 0.05). Compared with the non-punctured control group, IOF of NAG significantly increased the density of goblet cells in jejunum at hatch, duodenum at 7 D, and ileum at 14 D; decreased crypt depth in jejunum at hatch; and increased villus height in duodenum and jejunum and villus height:crypt depth ratio in duodenum at 7 D ( P < 0.05). The intestinal mRNA expression of Na + -dependent neutral amino acid transporter, peptide transporter, and excitatory amino acid transporter 3 did not differ between groups at 7 or 14 D. However, the mRNA expression level of rBAT in jejunum significantly increased in the NAG solution–injected group than in the non-punctured control group at 7 D ( P < 0.05). In conclusion, IOF of NAG (1.5 mg/egg) accelerated the early intestinal development by enhancing intestinal immune and absorption function, thereby positively affecting the feed efficiency for the first 2 wk post-hatch.

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Chick midgut morphogenesis

Cited by 23 publications

References 113 publications

An energy landscape approach to understanding variety and robustness in tissue morphogenesis

An energy landscape approach to understanding variety and robustness in tissue morphogenesis

Molecular and cellular basis of left–right asymmetry in vertebrates

Effects of in ovo feeding of N-acetyl-L-glutamate on early intestinal development and growth performance in broiler chickens

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