Chick Chorioallantoic Membrane as a Model for Simulating Human True Vocal Folds

Abstract

The CAM microvasculature suspended in albumen provides a useful surgical model simulating the microcirculation within the SLP of the human vocal fold. Although first-order CAM vessels best approximate the size of normal vocal fold subepithelial vessels seen at surgery, second- and third-order vessels resemble the vascular abnormalities frequently encountered during microsurgery for phonotraumatic lesions.

Effects of Gold Laser on the Avian Chorioallantoic Membrane

“…10,11 This model is likely to emerge as both a research tool and a resident training tool for office-based laryngeal laser surgery.…”

“…8,9 The chick chorioallantoic membrane (CAM) has been proposed as a model for predicting the effects of photoangiolytic lasers on vocal fold microvasculature. [10][11][12][13] The delicate vessels of the CAM are suspended in albumin, mimicking the suspended vasculature within the superficial layer of the lamina propria in the human vocal fold mucosa. An excellent review of the CAM model and its implications for laryngeal research is provided in the thesis publication by Burns et al 13 The purpose of this study was to evaluate the effects of the Gold laser in the CAM model in noncontact mode.…”

Predicting Clinical Efficacy of Photoangiolytic and Cutting/Ablating Lasers using the Chick Chorioallantoic Membrane Model: Implications for Endoscopic Voice Surgery

“…2, A and B). First‐order (small) vessels, from approximately 0.02 to 0.10 mm, represent the vessel size primarily studied because this size most closely approximates the vessel caliber near the phonatory surface of human vocal folds 37 . Second‐order vessels (0.11–0.41 mm) and third‐order vessels (0.42–0.98 mm) allow modeling for study of larger vocal‐fold vascular abnormalities such as varices, ectasias, and the vascular cores found in papilloma (Fig.…”

Innovative laser based approaches to laryngeal cancer: what an engineer and physicist need to know

“…The spectrum of laryngeal mucosal lesions treated by photoangiolysis consists of aberrant vessels of many sizes both smaller and larger than the normal vessel size (range of 0.015mm -0.1mm) 38 within the glottic microvasculature. Coagulation of vessels that are larger than normal, such as varices, is not expected to occur at pulse-width and power settings similar to those that effectively coagulate smaller caliber vessels.…”

“…First-order (small) vessels, from approximately .02mm -.10mm, represent the vessel size primarily studied because this size most closely approximates the vessel caliber near the phonatory surface of human vocal folds. 38 Second order vessels (.11mm -.41mm) and third order vessels (.42mm -.98mm) allow modeling for study of larger vocal-fold vascular abnormalities such as varices, ectasias, and the vascular cores found in papilloma (Figure 2 C-F).…”