Chewing ameliorates chronic mild stress-induced bone loss in senescence-accelerated mouse (SAMP8), a murine model of senile osteoporosis

Furuzawa, Manabu; Chen, Huayue; Fujiwara, Shu; Yamada, Kumiko; Kubo, Kin‐ya

doi:10.1016/j.exger.2014.03.003

Cited by 33 publications

(56 citation statements)

References 34 publications

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“…The results showed that chronic psychological stress induced significant decreases in trabecular bone volume, trabecular number, and trabecular thickness both in the vertebra and femurs. The bone quality, evaluated by biomechanical testing, was also reduced in stressed mice [14].…”

Section: Relationship Between Chronic Psychological Stress and Osteopmentioning

confidence: 94%

“…Recently, the association between chronic psychological stress and osteoporosis has been the subject of a growing body of research. The published literature, especially recent animal and human studies, showed that chronic psychological stress is a risk factor for developing osteoporosis [11][12][13][14][15]. In the present review, we aim to provide the current understanding of the relationship between chronic psychological stress and osteoporosis.…”

Section: Chronic Psychological Stress As a Risk Factor Of Osteoporosismentioning

confidence: 99%

“…Animal experiments with chronic psychological stress also showed the loss of bone mass and deterioration of bone quality [14,40]. Mice were exposed to a regimen of stressors every day over a period of 4 to 5 weeks.…”

Section: Relationship Between Chronic Psychological Stress and Osteopmentioning

confidence: 99%

“…Several human studies report that blood cortisol levels were elevated in depressed patients, concomitantly with low BMD [41,42]. Animal studies also showed an elevation of the circulating corticosterone levels and adrenal weight, accompanied by lower bone quantity and bone quality in chronic stressed mice [14,40]. Chronic stress triggers the hy-pothalamus to release CRH, activates the HPA axis, and stimulates the secretion of GC.…”

Section: Possible Mechanisms For Bone Fragility Induced By Chronic Psmentioning

confidence: 99%

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Chronic Psychological Stress as a Risk Factor of Osteoporosis

Chen

Adachi

Hayashi

et al. 2015

J UOEH

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: Osteoporosis, the most common metabolic skeletal disease, is characterized by decreased bone mass and deteriorated bone quality, leading to increased fracture risk. With the aging of the population, osteoporotic fracture is an important public health issue. Organisms are constantly exposed to various stressful stimuli that affect physiological processes. Recent studies showed that chronic psychological stress is a risk factor for osteoporosis by various signaling pathways. The purpose of this article is to review the recent progress of the association between chronic psychological stress and osteoporosis. Increasing evidence confirms the physiological importance of the central nervous system, especially the hypothalamus, in the regulation of bone metabolism. Both animal and human studies indicate that chronic psychological stress induces a decrease of bone mass and deterioration of bone quality by influencing the hypothalamic-pituitary-adrenocortical (HPA) axis, sympathetic nervous system, and other endocrine, immune factors. Active mastication, proven to be an effective stress-coping behavior, can attenuate stress-induced neuroendocrine responses and ameliorate stress-induced bone loss. Therefore, active mastication may represent a useful approach in preventing and/or treating chronic stress-associated osteoporosis. We also discuss several potential mechanisms involved in the interaction between chronic stress, mastication and osteoporosis. Chronic stress activates the HPA axis and sympathetic nervous system, suppresses the secretion of gonadal hormone and growth hormone, and increases inflammatory cytokines, eventually leading to bone loss by inhibiting bone formation and stimulating bone resorption.

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Section: Relationship Between Chronic Psychological Stress and Osteopmentioning

confidence: 94%

Section: Chronic Psychological Stress As a Risk Factor Of Osteoporosismentioning

confidence: 99%

Section: Relationship Between Chronic Psychological Stress and Osteopmentioning

confidence: 99%

Section: Possible Mechanisms For Bone Fragility Induced By Chronic Psmentioning

confidence: 99%

See 2 more Smart Citations

Chronic Psychological Stress as a Risk Factor of Osteoporosis

Chen

Adachi

Hayashi

et al. 2015

J UOEH

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“…Various chronic psychological or physical stress is linked to the development of many diseases, including anxiety, Alzheimer's disease, inflammatory disease, cancer, cardiovascular disorder, obesity and diabetes (Marin et al 2011;Proietti et al 2011;Reber 2012;Greenberg et al 2014). There is a lot of evidence indicating the association between chronic stress and bone loss (Patterson-Buckendahl et al 1995;Yirmiya et al 2006;Cizza et al 2009;Furuzawa et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Tooth Loss Early in Life Accelerates Age-Related Bone Deterioration in Mice

Kurahashi

Kondo

Iinuma

et al. 2015

Tohoku J. Exp. Med.

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Both osteoporosis and tooth loss are health concerns that affect many older people. Osteoporosis is a common skeletal disease of the elderly, characterized by low bone mass and microstructural deterioration of bone tissue. Chronic mild stress is a risk factor for osteoporosis. Many studies showed that tooth loss induced neurological alterations through activation of a stress hormone, corticosterone, in mice. In this study, we tested the hypothesis that tooth loss early in life may accelerate age-related bone deterioration using a mouse model. Male senescence-accelerated mouse strain P8 (SAMP8) mice were randomly divided into control and toothless groups. Removal of the upper molar teeth was performed at one month of age. Bone response was evaluated at 2, 5 and 9 months of age. Tooth loss early in life caused a significant increase in circulating corticosterone level with age. Osteoblast bone formation was suppressed and osteoclast bone resorption was activated in the toothless mice. Trabecular bone volume fraction of the vertebra and femur was decreased in the toothless mice with age. The bone quality was reduced in the toothless mice at 5 and 9 months of age, compared with the age-matched control mice. These findings indicate that tooth loss early in life impairs the dynamic homeostasis of the bone formation and bone resorption, leading to reduced bone strength with age. Long-term tooth loss may have a cumulative detrimental effect on bone health. It is important to take appropriate measures to treat tooth loss in older people for preventing and/or treating senile osteoporosis.

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The effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (HMG-CoA), on the prevention of osteoporosis in ovariectomized rabbits

et al. 2016

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Osteoporosis is a most frequent systemic skeletal disease characterized as low bone mineral density and microarchitectural deterioration of bone tissue, resulting in increased bone fragility and fracture risk. Although several drugs such as bisphosphonates, estrogen replacement treatment, and selective estrogen receptor modulators have been used to treat osteoporosis, all these are not the ideal drugs because of insufficient curative ability and adverse side effects. Recently, atorvastatin has ordinarily been prescribed as an anti-hyperlipidemia drug, not as an anti-osteoporosis drug. However, its clinical outcome and potential treatment mechanism are still unclear. In this study, the bilateral ovariectomy of rabbits was duplicated to develop osteoporosis animal model. The effect of atorvastatin on in vivo was determined, and the functional mechanism was studied in vitro after the curative effect was explored. Atorvastatin was observed to significantly increase the mechanical parameters such as maximum load, stiffness, and energy-absorbing capacity, and it improved the microarchitecture. The anti-osteoporosis activity of atorvastatin may be the result of the promotion of differentiation of osteoblasts by inducing synthesis of vascular endothelial growth factor, bone morphogenetic protein 2 (BMP2), core-binding factor alpha 1 (CBFα1), and inhibition of osteoclast formation through the osteoprotegerin (OPG)-receptor activator for the nuclear factor κB ligand (RANKL) system. Our study observations give reliable experimental evidence for clinical application of atorvastatin to treat the disorder of osteoporosis.

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Chewing ameliorates chronic mild stress-induced bone loss in senescence-accelerated mouse (SAMP8), a murine model of senile osteoporosis

Cited by 33 publications

References 34 publications

Chronic Psychological Stress as a Risk Factor of Osteoporosis

Chronic Psychological Stress as a Risk Factor of Osteoporosis

Tooth Loss Early in Life Accelerates Age-Related Bone Deterioration in Mice

The effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (HMG-CoA), on the prevention of osteoporosis in ovariectomized rabbits

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