Chest wall reconstruction with 3-dimensional custom-made carbon fiber ribs

Wang, Bin; Mei, Xilong; Li, Wenliang; Yu, Fenglei

doi:10.1016/j.jtcvs.2018.05.070

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Patch floating would have occurred if we had performed trachea repair with an autologous pericardial patch alone because of the large-sized defect, and tracheal stenosis and obstruction can easily occur in the late postoperative period. Therefore, combining the results of Aria's study with our own experience with 3D carbon fiber reconstruction implants (6)(7)(8), we designed a customized 3D carbon fiber stent outside the pericardial patch. The floating of the patch and tracheal stenosis were avoided by applying stent traction.…”

Section: Discussionmentioning

confidence: 99%

Trachea repair using an autologous pericardial patch combined with a 3D carbon fiber stent: A case report

Wang

Zhang²,

Guo³

et al. 2023

Front. Surg.

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This study is the first to use an autologous pericardial patch combined with a 3D carbon fiber stent for the plastic repair of a large trachea defect. Radical surgery is the optimal therapy for primary malignant tracheal tumors. Tracheoplasty or repair is required to guarantee trachea integrity and normal ventilation function after tracheal tumor resection. Here, we present a case of plastic repair of the trachea using an autologous pericardial patch and a 3D custom-made carbon fiber stent. A 4 cm trachea defect was successfully repaired after resecting a malignant schwannoma. The postoperative ventilatory function was normal without obvious symptoms of discomfort. Fiberoptic bronchoscopy showed a smooth mucosal surface of the endotracheal wall and patency of the airway. CT scans performed 3 years after surgery showed no recurrence. Therefore, we can conclude that a 3D carbon fiber stent is feasible for abolishing patch floating and preventing tracheal stenosis.

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Section: Discussionmentioning

confidence: 99%

Trachea repair using an autologous pericardial patch combined with a 3D carbon fiber stent: A case report

Wang

Zhang²,

Guo³

et al. 2023

Front. Surg.

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“…Traditional techniques, such as the use of prolene mesh (PM) and metal bars, are the most frequently used methods in reconstruction. The use of complex implants that are individualized and produced with a 3D printer stands out as a good alternative to classical methods (3,4). In the present study, we aimed to evaluate of the 16-year surgical experience of a tertiary hospital thoracic surgery clinic in chest wall masses.…”

Section: Introductionmentioning

confidence: 99%

Approach to chest wall masses: Analysis of a single-center outcomes

Işık¹,

İnan²,

Karataş³

et al. 2021

GMJ

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Methods:We retrospectively evaluated the medical records of patients with a chest wall mass, who were admitted between January 2003 and December 2019. The data related to age, gender, chief complaints on admission, tumor localization, requirement of surgical treatment, length of hospital stay, histopathological diagnosis, recurrence, morbidities and mortality were recorded. Results:The total sample included 185 patients [mean age (range): 37.6 years (12 to 88), male gender: 144 (77.8%)]. The mean length of hospitalization was 6.62 days (1-35). The most common complaints on admission were a palpable mass (n=60, 32.4%), pain (n=59, 31.9%), and pain and a palpable mass (n=36, 19.4%). Surgery was required in 166 (89.8%) patients. More than one surgery was performed in 8 (4.8%) patients. There were 118 (71%) benign and 48 (29%) malignant histopathologic results. The most common primary chest wall malignancies were chondrosarcoma and Ewing sarcoma. Conclusions:The majority of patients with a chest wall mass underwent surgery in this 16-year dataset. Chondrosarcoma and Ewing sarcoma were the most common primary malignancies. While most were benign tumors, a secondary intervention was required in a small percentage of patients.

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“…2,3 Traditional approaches for bone reconstruction include autologous bone transplantation, allografts, and the use of artificial implants. [4][5][6][7] Autologous bones serve as the ideal materials for bone repair, but the applications are limited by the donor site morbidity, insufficiency, and low availability of bone grafts. 4,8 Compared to autografts, allografts are associated with the risk of rejection reaction and infection.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2

Wang

Guo

Chen

et al. 2018

IJN

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BackgroundStromal cell-derived factor 1 (SDF-1) is an important chemokine for stem cell mobilization, and plays a critical role in mobilization of mesenchymal stem cells (MSCs). Bone morphogenetic protein 2 (BMP-2) plays a critical role in osteogenesis of MSCs. However, the use of SDF-1 and BMP-2 in bone tissue engineering is limited by their short half-lives and rapid degradation in vitro and in vivo.MethodsThe chitosan oligosaccharide/heparin nanoparticles (CSO/H NPs) were first prepared via self-assembly. Chitosan-agarose-gelatin (CAG) Scaffolds were then synthesized via gelation technology using cross-linked chitosan, agarose, and gelatin, and were modified by CSO/H NPs. The encapsulation efficiency and release kinetics of SDF-1 and BMP-2 were quantified using an enzyme-linked immunosorbent assay. A CCK-8 assays were used to evaluate biocompatibility of NP-modified scaffolds. The biological activity of the loaded SDF-1 and BMP-2 was evaluated using the transwell migration assay and osteogenic induction assay. An animal MSC recruitment model was used to study the ability of SDF-1 released from NP-modified scaffolds to induce migration of MSCs.ResultsIn this study, we developed a novel nanoparticle-modified CAG scaffold for the delivery of SDF-1 and BMP-2. CCK-8 assays demonstrated excellent biocompatibility of NP-modified scaffolds. In addition, we investigated the release of SDF-1 and BMP-2 from NP-modified scaffolds, and evaluated the effect of released SDF-1 on MSC migration. The effect of released BMP-2 on MSC osteogenesis was also examined. In vitro cell migration assays showed that SDF-1 released from NP-modified scaffolds retained its migration activity; osteogenesis studies demonstrated that released BMP-2 exhibited a strong ability to induce differentiation towards osteoblasts. Our in vivo recruitment assays showed continuous chemotactic response of MSCs to SDF-1 released from the NP-modified scaffold.ConclusionThe simplicity of synthesizing CSO/H NP-modified CAG scaffolds, combined with its high cytokine loading capacity and sustained release effect, renders NP-modified CAG scaffold an attractive candidate for sustained release of SDF-1 and BMP-2 to promote bone repair and regeneration.

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Chest wall reconstruction with 3-dimensional custom-made carbon fiber ribs

Abstract: Three-dimensional carbon fiber ribs for chest wall reconstruction. Central MessageWe report reconstruction of a large chest wall defect using 3-dimensional custom-made carbon fiber ribs.

Cited by 9 publications

References 4 publications

Trachea repair using an autologous pericardial patch combined with a 3D carbon fiber stent: A case report

Trachea repair using an autologous pericardial patch combined with a 3D carbon fiber stent: A case report

Approach to chest wall masses: Analysis of a single-center outcomes

Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2

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