Chest pain and arthritis

Levine, Michael; Wong, Deborah Jean Lee; Brown, David F.M.; Nadel, Eric S.

doi:10.1016/j.jemermed.2005.04.001

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Sodium salicylate (SS), the active component of aspirin, is one of the most widely used over the counter drugs for the treatment of pain, fever, inflammation, heart attacks, chest pain and a host of other health conditions (Lewis et al, 1983, Levine et al, 2005, Cheng, 2007). Aspirin has been implicated Reye’s syndrome, a childhood disorder characterized by hyperammonemia and encephalopathy and which may involve mitochondrial permeability transition (Trost and Lemasters, 1996, Larsen, 1997).…”

Section: Introductionmentioning

confidence: 99%

Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling

Wei¹,

Ding²,

Salvi³

2010

Neuroscience

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Aspirin, whose active ingredient is sodium salicylate, is the most widely used drugs worldwide, but it is not recommend for children because it may causes Reye's syndrome. High doses of salicylate also induce temporary hearing loss and tinnitus; while these disorders are believed to disappear when treatment is discontinued some data suggest that prolonged treatment may be neurotoxic. To investigate its ototoxicity, immature, postnatal day 3 rat cochlear organotypic cultures were treated with salicylate. Salicylate did not damage the sensory hair cells, but instead damaged the spiral ganglion neurons and their peripheral fibers in a dose-dependent manner. The cross sectional area of spiral ganglion neurons decreased from 205 μm 2 in controls to 143, 116 and 91 μm 2 in cultures treated with 1, 3 or 5 mM salicylate respectively. Morphological changes and caspase upregulation were indicative of caspase-mediated apoptosis. A quantitative RT-PCR apoptosis array identified a subset of genes up or down regulated by salicylate. Eight genes showed a biologically relevant change (P < 0.05, ≥ 2 fold change) after 3 h treatment with salicylate; 7 genes (Tp53, Birc3, Tnfrsf5, Casp7, Nfkb1, Fas, Lta, Tnfsf10) were upregulated and 1 gene (Pycard) was downregulated. After 6 h treatment, only 1 gene (Nol3) was upregulated and 2 genes were downregulated (Cideb and Lhx4) while after 12 h treatment, 2 genes (Il10, Gadd45a) were upregulated and 4 (Prok2, Card10, Ltbr, Dapk1) were downregulated. High doses of salicylate in a physiologically relevant range can induce caspase-mediated cell death in immature spiral ganglion neurons; changes in the expression of apoptotic genes particularly among members of the TNF family appear to play an important role in the degeneration.

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Section: Introductionmentioning

confidence: 99%

Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling

Wei¹,

Ding²,

Salvi³

2010

Neuroscience

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“…However, other studies included in this review did not find a statistically significant difference in complication rates between the two groups [ 10 ]. Factors such as variations in surgical techniques, patient population, severity of trauma, and adherence to standardized protocols might contribute to these inconsistent findings.…”

Section: Reviewmentioning

confidence: 77%

“…However, other studies did not find a statistically significant difference in complication rates between the two groups [ 10 ]. These inconsistent findings may be influenced by various factors, such as variations in surgical techniques, patient population, severity of trauma, and adherence to standardized protocols.…”

Section: Reviewmentioning

confidence: 90%

Comparative Analysis of Outcomes and Complications of Pediatric Trauma Surgeries Performed by General Surgeons Versus Specialized Pediatric Trauma Surgeons: A Review of the Literature

Turaga

2023

Cureus

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Pediatric trauma surgeries require specialized expertise to ensure optimal outcomes and minimize complications. This review aims to compare the outcomes and complications of pediatric trauma surgeries performed by general surgeons versus specialized pediatric trauma surgeons, based on the analysis of relevant papers. A literature search was conducted, and 10 papers were chosen for analysis. The selected papers included comparative data on outcomes and complications between general and specialized pediatric trauma surgeons. Specialized pediatric trauma surgeons consistently demonstrated superior outcomes compared with general surgeons. They had lower mortality rates and improved functional outcomes, shorter hospital stays, and lower complication rates. Multidisciplinary collaboration among specialized pediatric trauma surgical teams enhanced communication and patient management. The findings support the advantages of specialized pediatric trauma surgeons, who possess specific training in pediatric anatomy, physiology, and surgical techniques. Their expertise enables them to address the unique challenges of pediatric trauma and tailor interventions accordingly. The multidisciplinary approach facilitated by specialized teams further enhances outcomes. Specialized pediatric trauma surgeons offer distinct advantages over general surgeons in pediatric trauma surgeries. Their expertise, tailored interventions, and multidisciplinary collaboration contribute to improved outcomes and reduced complications. Efforts should be directed toward establishing specialized pediatric trauma surgical teams and enhancing access to specialized expertise.

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Enzymology of Mitochondrial Amino Acid Conjugation Reactions

van der Sluis,

Knights

2023

Reference Module in Biomedical Sciences

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Chest pain and arthritis

Cited by 5 publications

References 12 publications

Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling

Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling

Comparative Analysis of Outcomes and Complications of Pediatric Trauma Surgeries Performed by General Surgeons Versus Specialized Pediatric Trauma Surgeons: A Review of the Literature

Enzymology of Mitochondrial Amino Acid Conjugation Reactions

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