Chest Imaging with Dual-Energy Subtraction Digital Tomosynthesis

Sone, S.; Kasuga, T.; Sakai, F.; Hirano, H.; Kubo, K.; Morimoto, M.; Takemura, K.; Hosoba, M.

doi:10.3109/02841859309173255

Cited by 11 publications

(6 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…Another concern regarding practicability is the need for fast kV‐switching in combination with different filters for the LE and HE spectra. Again, Sone et al 36 . showed that it is possible to switch between LE and HE tube voltages at 15 Hz in synchrony with a rotating filter.…”

Section: Discussionmentioning

confidence: 99%

“…It is likely not necessary to sample at such a fine angular increment, but it may be beneficial to use a larger angular range. For example, in a study of DE tomosynthesis, Sone et al 36 used a ±40 • angular range with ∼1.67 • angular increments and a total scan time of 6.4 s. These scan times are shorter than those used in hyper-polarized noble-gas MRI, which can be 15 s in duration. 23,61 Furthermore, a number of hyper polarized noble-gas MRI studies have shown that such breath-hold lengths are feasible for patients suffering from COPD 25,26 and cystic fibrosis 62,63 and yield images of sufficient quality uncompromised by motion artifacts.…”

Section: Discussionmentioning

confidence: 99%

“…Single‐energy tomosynthesis has recently been shown to have high sensitivity to emphysema‐related changes in lung structure while using less than one tenth of the radiation dose of CT 34,35 . In addition, DE tomosynthesis using a kV‐switching approach in combination with a rotating copper filter is practicable in a clinical setting 36 …”

Section: Introductionmentioning

confidence: 99%

“…Tomosynthesis is limited-angle CT that produces high-spatialresolution coronal images of the chest, but with depth resolution that is much inferior to that of CT. 32,33 Singleenergy tomosynthesis has recently been shown to have high sensitivity to emphysema-related changes in lung structure while using less than one tenth of the radiation dose of CT. 34,35 In addition, DE tomosynthesis using a kV-switching approach in combination with a rotating copper filter is practicable in a clinical setting. 36 The technique we propose uses tomosynthesis to produce Xe-enhanced low-energy (LE) and high-energy (HE) images of coronal planes that lie between the anterior and posterior ribs, thereby partially suppressing the contribution of the ribs to anatomic noise. DE subtraction of the resulting images would then suppress soft tissues to produce a 2D map of lung ventilation within the given slice.…”

Section: Introductionmentioning

confidence: 99%

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Xenon‐enhanced dual‐energy tomosynthesis for functional imaging of respiratory disease—Concept and phantom study

Tanguay

Basharat

2022

Medical Physics

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Background Xenon‐enhanced dual‐energy (DE) computed tomography (CT) and hyperpolarized noble‐gas magnetic resonance imaging (MRI) provide maps of lung ventilation that can be used to detect chronic obstructive pulmonary disease (COPD) early in its development and predict respiratory exacerbations. However, xenon‐enhanced DE‐CT requires high radiation doses and hyper‐polarized noble‐gas MRI is expensive and only available at a handful of institutions globally. Purpose To present xenon‐enhanced dual‐energy tomosynthesis (XeDET) for low‐dose, low‐cost functional imaging of respiratory disease in an experimental phantom study. Methods We propose using digital tomosynthesis to produce Xe‐enhanced low‐energy (LE) and high‐energy (HE) coronal images. DE subtraction of the LE and HE images is used to suppress soft tissues. We used an imaging phantom to investigate image quality in terms of the area under the reciever operating characteristic curve (AUC) for the Non‐PreWhitening model observer with an Eye filter and internal noise (NPWEi). The phantom simulated anatomic clutter due to lung parenchyma and attenuation due to soft tissue and lung tissue. Aluminum slats were used to simulate rib structures. A stepwedge consisting of an acrylic casing with sealed cylindrical air‐filled cavities was used to simulate ventilation defects with step thicknesses of 0.5, 1, and 2 cm and cylindrical radii of 0.5, 0.75, and 1 cm. The phantom was ventilated with Xe and projection data were acquired using a flat‐panel detector, a tube‐voltage combination of 60/140 kV with 1.2 mm of copper filtration on the HE spectrum and an angular range of ±15∘$\pm 15^{\circ}$ in 1° increments. The AUC of a NPWEi observer that has access only to a single coronal slice was calculated from measurements of the three‐dimensional noise power spectrum and signal template. The AUC was calculated as a function of ventilation defect thickness and radius for total patient entrance air kermas ranging from 1.42 to 2.84 mGy with and without rib‐simulating Al slats. For the AUC analysis, the observer internal noise level was obtained from an ad hoc calibration to a high‐dose data set. Results XeDET was able to suppress parenchyma‐simulating clutter in coronal images enabling visualization of the simulated ventilation defects, but the limited angle acquisition resulted in residual clutter due to out‐of‐plane bone‐mimmicking structures. The signal power of the defects increased linearly with defect radius and showed a ten‐fold to fifteen‐fold increase in signal power when the defect thickness increased from 0.5 to 2 cm. These trends agreed with theoretical predictions. Along the depth dimension, the power of the defects decreased exponentially with distance from the center of the defects with full‐width half maxima that varied from 1.85 to 2.85 cm depending on the defect thickness and radius. The AUCs of the 1‐cm‐radius defect that was 2 cm in thickness ranged from good (0.8–0.9) to excellent (0.9–1.0) over the range of air kermas considered. Conclusions Xen...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%