Chest CT Signs in Pulmonary Disease

Raju, Shine; Ghosh, Subha; Mehta, Atul C.

doi:10.1016/j.chest.2016.12.033

Cited by 78 publications

(57 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The images were scored from 0 to 3 based on the previous veterinary and human data. In thoracic CT images, a score of 0 was equivalent to a normal thorax.…”

Section: Methodssupporting

confidence: 89%

Bronchoalveolar lavage affects computed tomographic and radiographic characteristics of the lungs in healthy dogs

Lim

Sung

Min

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Bronchoalveolar lavage is a common diagnostic test for dogs with suspected pulmonary disease, however there is no published information on whether this procedure could affect the imaging characteristics of the lungs. Aims of this prospective experimental study were to describe computed tomography (CT) and radiographic features of the lungs after bronchoalveolar lavage in a sample of healthy dogs. Thoracic CT and radiographic images of eight healthy Beagles were acquired at the following time points: before bronchoalveolar lavage, immediately following bronchoalveolar lavage, and at 2, 4, 8, 12, and 24 h following bronchoalveolar lavage. Lung consolidation or interstitial patterns were seen in CT and radiographic images immediately after the procedure. Radiographic lung patterns resolved within 2 h and CT patterns resolved within 24 h. Resolution of the CT pulmonary patterns in the ventral areas of the lungs was delayed compared to the dorsal areas. Mean CT imaging scores differed over time (P < 0.001), while mean radiographic imaging scores did not differ over time. This study suggests that thoracic radiography and CT imaging assessments should precede bronchoalveolar lavage procedures if possible, or be performed at least 24 h afterward.

show abstract

“…The images were scored from 0 to 3 based on the previous veterinary and human data. In thoracic CT images, a score of 0 was equivalent to a normal thorax.…”

Section: Methodssupporting

confidence: 89%

Bronchoalveolar lavage affects computed tomographic and radiographic characteristics of the lungs in healthy dogs

Lim

Sung

Min

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…Sub-solid nodules were defined as nodules containing any ground glass opacity within the lesion [ 16 ]. In addition, we analyzed the presence of the open bronchus sign, which was defined as an intra-lesional bronchiolar dilatation that continued to a proximal bronchus with a preserved luminal patency [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Bronchovascular injury associated with clinically significant hemoptysis after CT-guided core biopsy of the lung: Radiologic and histopathologic analysis

et al. 2018

View full text Add to dashboard Cite

ObjectiveTo evaluate bronchovascular injuries as the causative occurrence for clinically significant hemoptysis after percutaneous transthoracic needle biopsy (PTNB).Materials and methodsWe included 111 consecutive patients who experienced hemoptysis after cone beam CT (CBCT)-guided PTNB from January 2014 through January 2017. Clinically significant hemoptysis was defined as hemoptysis causing hemodynamic instability or oxygen desaturation greater than 10% of baseline. The lesion characteristics were evaluated on CT images. The penetration of bronchovascular structures along the trajectory of the introducer needle and potential penetration at the firing of the biopsy gun were assessed on CBCT images. The cutting injury of bronchovascular structures was histopathologically assessed in biopsy specimens. The associated factors for clinically significant hemoptysis were assessed using logistic regression analyses.ResultsSeventeen patients (15.3%; 95%CI, 9.7%-23.2%) had clinically significant hemoptysis. On univariate analysis, the open bronchus sign (P = .004), nodule consistency (P = .012), potential penetration of a pulmonary vessel or bronchus 1 mm or larger at firing (P = .008 and P = .038, respectively), and a cutting injury of a pulmonary vessel 1 mm or larger (P = .007) or a bronchial structure (P = .041) were associated with clinically significant hemoptysis. Multivariate analysis found the following significant associated factors: potential penetration of a pulmonary vessel 1 mm or larger at firing (OR, 3.874; 95%CI, 1.072–13.997; P = .039) and cutting injury of a pulmonary vessel 1 mm or larger (OR, 6.920; 95%CI, 1.728–27.711; P = .006) or a bronchial structure (OR 4.604; 95%CI, 1.194–17.755; P = .027).ConclusionPotential penetration and cutting injury of bronchovascular structures 1mm or larger at firing were independently associated with clinically significant hemoptysis after PTNB.

show abstract

“…Although solid lung nodules can occur in invasive aspergillosis, they are associated with a halo sign or air‐crescent sign, are almost invariably encountered in severely immunocompromised individuals, and are characterised by vascular invasion on pathological examination, none of which were seen in our cases. Additionally, these lesions are not aspergillomas, which occur in the setting of pre‐existing cavitary lung disease and are characterised on imaging by mobile intracavitary masses with surrounding air (Monod sign), and on histopathological examination by tangled masses of fungal hyphae (fungus balls, or mycetomas) floating within a cavity or ectatic bronchus . In contrast to aspergillomas, which represent non‐invasive/saprophytic disease in which fungi are limited to the lumen of dilated airways (cavities), the organisms in our cases were not located within pre‐existing cavities or airway lumens.…”

Section: Discussionmentioning

confidence: 63%

Expanding the spectrum of chronic necrotising (semi‐invasive) aspergillosis: a series of eight cases presenting as radiologically solid lung nodules mimicking malignancy

2020

Self Cite

View full text Add to dashboard Cite

Aim: To clinicopathologically characterise a subset of aspergillosis cases characterised by radiologically solid lung nodules. Methods and results: We reviewed our archives for lung biopsies/resections with fungal hyphae on histology. Cases classifiable as a well-established form of aspergillosis were excluded. Unclassifiable cases with radiologically solid lung nodules and histological evidence of fungal hyphae consistent with Aspergillus were analysed in detail. Of 134 lung biopsies/ resections with fungal hyphae, eight presented as a solid lung nodule on imaging and could not be classified as a well-recognised form of aspergillosis. All patients were non-immunocompromised/minimally immunocompromised adult smokers. Imaging showed solid, predominantly solitary, spiculated, subpleural, hypermetabolic upper lobe nodules in emphysematous lungs. Malignancy was suspected clinically in all cases. Histologically, the nodules were necrotising granulomas containing fungal hyphae consistent with Aspergillus. On follow-up, none of the nodules recurred or progressed to invasive disease. Conclusions: Aspergillosis can present as a radiologically solid, spiculated lung nodule suspicious for malignancy. Materials and methodsAfter approval from the Cleveland Clinic Institutional Review Board had been obtained (IRB no. 17-072), 134 lung biopsies and resections containing fungal hyphae from a 19-year period (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) were retrieved from our surgical pathology archives. In each case, the electronic medical record was reviewed

show abstract

Chest CT Signs in Pulmonary Disease

Cited by 78 publications

References 61 publications

Bronchoalveolar lavage affects computed tomographic and radiographic characteristics of the lungs in healthy dogs

Bronchoalveolar lavage affects computed tomographic and radiographic characteristics of the lungs in healthy dogs

Bronchovascular injury associated with clinically significant hemoptysis after CT-guided core biopsy of the lung: Radiologic and histopathologic analysis

Expanding the spectrum of chronic necrotising (semi‐invasive) aspergillosis: a series of eight cases presenting as radiologically solid lung nodules mimicking malignancy

Contact Info

Product

Resources

About