“…The references included in publications, websites of national reports and academic non-government organizations yielded 22 new articles fitting our criteria. We excluded 106 articles and, ultimately, included 37 articles in this review ( Figure 1 ): four case-control studies( 13 , 14 , 15 , 16 ), nine cases series( 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ), 23 case reports( 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ), and one national report( 10 ). Figure 1 Selection of studies …”
Section: Resultsmentioning
confidence: 99%
“…A descriptive analysis based on 33 articles and a meta-analysis based on 4 case-control studies was performed. For the descriptive analysis, we included a total of 322 pregnant women, 111 (34.5%) patients from Netherlands( 10 ), 80(24.8%) from USA( 17 , 19 , 21 , 40 , 42 , 46 ), 76(23.6%) from China ( 22 , 23 , 26 , 27 , 30 , 32 , 33 , 37 , 39 , 47 ), 43(13.3%) from Italy ( 18 , 29 ), 2(0.6%) from Canada( 20 ), and one each from Honduras( 28 ), South Korea( 31 ), Sweden( 34 ), Germany( 35 ), Turkey( 36 ), Iran( 38 ), Australia( 41 ), Spain( 43 ), Peru( 44 ), and India( 45 ). ( Supplemental Table 2 ) One case series(24) and one case report(48) from China were considered for analysis of vertical transmission.…”
Section: Resultsmentioning
confidence: 99%
“…Most studies had the same rate of non-response for both groups ( Supplemental Table 3a ). The quality of case series and case reports evaluated using the modified NOS were: three studies were deemed to be good( 20 , 26 , 46 ), 23 were moderate( 17 , 19 , 22 , 23 , 24 , 27 , 28 , 29 , 30 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 47 , 48 ), and six were poor in methodological quality ( Supplemental Table 3b )( 18 , 21 , 25 , 32 , 33 , 45 ). The Dutch Association for Obstetrics and Gynecology’s official report was no assessed for quality( 10 ).…”
Section: Resultsmentioning
confidence: 99%
“…Twenty articles including 88 patients reported the laboratory characteristics ( 19 , 20 , 22 , 28 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 40 , 42 , 43 , 44 , 46 , 47 ). Table 2 describes lymphopenia (n=52,59.1%), elevated concentrations of C-reactive protein (n=46, 52.3%) and leukopenia (n=23,26.1%) as the most common findings.…”
“…The references included in publications, websites of national reports and academic non-government organizations yielded 22 new articles fitting our criteria. We excluded 106 articles and, ultimately, included 37 articles in this review ( Figure 1 ): four case-control studies( 13 , 14 , 15 , 16 ), nine cases series( 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ), 23 case reports( 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ), and one national report( 10 ). Figure 1 Selection of studies …”
Section: Resultsmentioning
confidence: 99%
“…A descriptive analysis based on 33 articles and a meta-analysis based on 4 case-control studies was performed. For the descriptive analysis, we included a total of 322 pregnant women, 111 (34.5%) patients from Netherlands( 10 ), 80(24.8%) from USA( 17 , 19 , 21 , 40 , 42 , 46 ), 76(23.6%) from China ( 22 , 23 , 26 , 27 , 30 , 32 , 33 , 37 , 39 , 47 ), 43(13.3%) from Italy ( 18 , 29 ), 2(0.6%) from Canada( 20 ), and one each from Honduras( 28 ), South Korea( 31 ), Sweden( 34 ), Germany( 35 ), Turkey( 36 ), Iran( 38 ), Australia( 41 ), Spain( 43 ), Peru( 44 ), and India( 45 ). ( Supplemental Table 2 ) One case series(24) and one case report(48) from China were considered for analysis of vertical transmission.…”
Section: Resultsmentioning
confidence: 99%
“…Most studies had the same rate of non-response for both groups ( Supplemental Table 3a ). The quality of case series and case reports evaluated using the modified NOS were: three studies were deemed to be good( 20 , 26 , 46 ), 23 were moderate( 17 , 19 , 22 , 23 , 24 , 27 , 28 , 29 , 30 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 47 , 48 ), and six were poor in methodological quality ( Supplemental Table 3b )( 18 , 21 , 25 , 32 , 33 , 45 ). The Dutch Association for Obstetrics and Gynecology’s official report was no assessed for quality( 10 ).…”
Section: Resultsmentioning
confidence: 99%
“…Twenty articles including 88 patients reported the laboratory characteristics ( 19 , 20 , 22 , 28 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 40 , 42 , 43 , 44 , 46 , 47 ). Table 2 describes lymphopenia (n=52,59.1%), elevated concentrations of C-reactive protein (n=46, 52.3%) and leukopenia (n=23,26.1%) as the most common findings.…”
“…Clinical manifestations in pregnant women range from asymptomatic to mild symptoms, sometimes with atypical findings such as leucocytosis and higher prevalence of consolidation lesions in the computed tomography (CT) images [69][70][71].…”
Since 31 December 2019 and as of 7 April 2020, over 1.3 million (1 316 988) cases of COVID-19 have been reported worldwide, and more than 70 000 (74 066) deaths. Half of these cases (608 500) have been reported from the EU/EEA countries and the UK, and over 50 000 (51 059) of them have died. Overall, large increases in COVID-19 cases and deaths continue to be reported from the EU/EEA countries and the UK. In addition, in recent weeks, the European all-cause mortality monitoring system showed all-cause excess mortality above the expected rate in Belgium,
Background: Clinical presentation and outcomes of COVID-19 infection during pregnancy remain limited and fragmented. Objectives: To summarize the existing literature on COVID-19 infection during pregnancy and childbirth, particularly concerning clinical presentation and outcomes. Search strategy: A systematic search of LitCovid, EBSCO MEDLINE, CENTRAL, CINAHL, Web of Science, and Scopus electronic databases. The references of relevant studies were also searched.Selection criteria: Identified titles and abstracts were screened to select original reports and cross-checked for overlap of cases.
Data collection and analysis:A descriptive summary organized by aspects of clinical presentations (symptoms, imaging, and laboratory) and outcomes (maternal and perinatal).
Main results:We identified 33 studies reporting 385 pregnant women with COVID-19 infection: 368 (95.6%) mild; 14 (3.6%) severe; and 3 (0.8%) critical. Seventeen women were admitted to intensive care, including six who were mechanically ventilated and one maternal mortality. A total of 252 women gave birth, comprising 175 (69.4%) cesarean and 77 (30.6%) vaginal births. Outcomes for 256 newborns included four RT-PCR positive neonates, two stillbirths, and one neonatal death.
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