Chernobyl Tumor Bank

Thomas, G; Williams, E. D.; Becker, Dennis; Bogdanova, Tetiana; Demidchik, Eugene P.; Lushnikov, E F; Nagataki, S; Остапенко, В В; Pinchera, Aldo; Souchkevitch, G.; Тronko, М.D.; Цыб, А Ф; Tuttle, Mark S.; Yamashita, S.

doi:10.1089/thy.2000.10.1126a

Cited by 20 publications

(16 citation statements)

References 3 publications

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“…The pathological classification was based on World Health Organization (WHO) definitions (23). All diagnoses were reviewed and confirmed by international experts in the course of joint research projects and/or at the Chernobyl Tissue Bank (CTB) Pathology Panel sessions (24). Tumors were further classified according to the dominant histological growth pattern into three categories: papillary, follicular, or solid-trabecular (when corresponding structure represented >50% of a tumor).…”

Section: Histopathologymentioning

confidence: 99%

Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident

Bogdanova

Saenko

Brenner

et al. 2018

Thyroid

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Section: Histopathologymentioning

confidence: 99%

Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident

Bogdanova

Saenko

Brenner

et al. 2018

Thyroid

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“…20 These ongoing studies have produced important, but sometimes controversial, results; however, the Chernobyl accident has engendered many projects involving the pathology of thyroid carcinoma, especially papillary subtypes. (Indeed, the international effort included the appointment of an international panel of thyroid pathologists to examine and render consensus diagnoses on the cases of thyroid cancer occurring in the exposed populations 20,21 .) The rest of this review will focus on pathologic aspects of papillary thyroid carcinoma in general, the common important subtypes and their clinicopathologic, molecular, and epidemiologic correlates.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Papillary thyroid carcinoma: an update

2011

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The past two decades have seen numerous developments in the understanding of the origins and biology of papillary thyroid carcinoma. Advances in molecular biology, clinicopathologic studies of new entities, facility with fine-needle aspiration biopsy, and new radiologic imaging techniques have allowed for earlier diagnosis of these tumors. However, these advances have also caused controversies in cytologic and histopathologic diagnoses as well as therapy decisions. This paper will focus on several pathologic aspects of papillary carcinoma, which impact on its biology and prognosis.

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“…CTB tumours are papillary cancers collected in young people who were exposed to the Chernobyl accident ( (Thomas et al, 2000), see patient information, Table 1). There are 9 tumours of classical subtype, 4 of follicular subtype and 1 of trabecular subtype among the 14 French PTC samples.…”

Section: Expression Profiles and Gene Alteration Status Of Ptcs From mentioning

confidence: 99%

Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers

et al. 2007

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Papillary thyroid cancers (PTCs) incidence dramatically increased in the vicinity of Chernobyl. The cancer-initiating role of radiation elsewhere is debated. Therefore, we searched for a signature distinguishing radio-induced from sporadic cancers. Using microarrays, we compared the expression profiles of PTCs from the Chernobyl Tissue Bank (CTB, n ¼ 12) and from French patients with no history of exposure to ionising radiations (n ¼ 14). We also compared the transcriptional responses of human lymphocytes to the presumed aetiological agents initiating these tumours, g-radiation and H 2 O 2 . On a global scale, the transcriptomes of CTB and French tumours are indistinguishable, and the transcriptional responses to g-radiation and H 2 O 2 are similar. On a finer scale, a 118 genes signature discriminated the g-radiation and H 2 O 2 responses. This signature could be used to classify the tumours as CTB or French with an error of 15 -27%. Similar results were obtained with an independent signature of 13 genes involved in homologous recombination. Although sporadic and radio-induced PTCs represent the same disease, they are distinguishable with molecular signatures reflecting specific responses to g-radiation and H 2 O 2 . These signatures in PTCs could reflect the susceptibility profiles of the patients, suggesting the feasibility of a radiation susceptibility test.

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Chernobyl Tumor Bank

Cited by 20 publications

References 3 publications

Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident

Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident

Papillary thyroid carcinoma: an update

Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers

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