Chemotherapy with Cyclophosphamide, Vincristine, and Prednisolone (COP) in Cats with Malignant Lymphoma: New Results with an Old Protocol

Teske, Erik; Straten, Giora van; Noort, Ronald van; Rutteman, Gerard R.

doi:10.1111/j.1939-1676.2002.tb02352.x

Cited by 126 publications

(202 citation statements)

References 16 publications

(17 reference statements)

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“…Cats with alimentary lymphoma had a significantly shorter median survival than cats with nasal or mediastinal lymphoma in the present study. Alimentary lymphoma has previously been described to have unsatisfactory treatment results [9, 10, 14], and mediastinal lymphoma has also been reported to carry a poorer prognosis [5, 17]. In the present study, the median age of cats with mediastinal lymphoma was 10 years which was older than that described in previous reports, and only 10 (53%) of the 19 cats with mediastinal lymphoma were positive for FeLV antigen in the blood.…”

Section: Discussioncontrasting

confidence: 48%

Prognostic Analyses on Anatomical and Morphological Classification of Feline Lymphoma

et al. 2014

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The present study was carried out to analyze the prognosis of 163 cats with lymphoma classified anatomically and cytomorphologically. Anatomically, alimentary lymphoma was the most common form and showed significantly shorter survival than mediastinal and nasal lymphomas in cats. Cytomorphologically, there was no predominant subtype in feline lymphomas. Immunoblastic type (18%), centroblastic type (16%), globule leukocyte type (15%), lymphocytic type (12%), lymphoblastic type (12%), pleomorphic medium and large cell type (10%) and anaplastic large cell type (7%) were relatively common subtypes. Most of the cats with globule leukocyte lymphoma had the alimentary form. Comparing median survival time among classifications, cats with globule leukocyte lymphoma showed significantly shorter survival than those with high-grade and other low-grade lymphomas. Furthermore, cats with high-grade lymphomas showed significantly shorter survival than cats with other low-grade lymphomas. The present study indicated the clinical significance of anatomical and cytomorphological evaluation in feline lymphomas.

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Section: Discussioncontrasting

confidence: 48%

Prognostic Analyses on Anatomical and Morphological Classification of Feline Lymphoma

et al. 2014

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“…Safety and efficacy of cyclophosphamide and vincristine administered IP to 26 cats with various forms of malignant lymphoma have been confirmed. 7 No specific IP-related adverse effects were seen in any cats of that study, 7 and cats had similar survival times after administration via that route, compared with survival times for other reports, 4–6,13 which indicated probable efficacy. A pharmacokinetic analysis revealed equal bioavailability of the parent compound (cyclophosphamide) given IV or IP; however, the active metabolite 4-OHCP was not measured.…”

supporting

confidence: 47%

Pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in cats after oral, intravenous, and intraperitoneal administration of cyclophosphamide

Stroda¹,

Murphy²,

Hansen³

et al. 2017

ajvr

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OBJECTIVE To characterize pharmacokinetics of cyclophosphamide and 4-hydoxycyclophosphamide (4-OHCP) in the plasma of healthy cats after oral, intravenously, or intraperitoneal administration of cyclophosphamide. ANIMALS 6 healthy adult cats. PROCEDURES Cats were randomly assigned to receive 200 mg/m2 of cyclophosphamide via each of 3 routes of administration (oral, IV, and IP); there was a 30-day washout period between successive treatments. Plasma samples were obtained at various time points for up to 8 hours after administration. Samples were treated with semicarbazide hydrochloride to trap the 4-OHCP in stable form, which allowed for cyclophosphamide and trapped 4-OHCP to be simultaneously measured by use of tandem mass spectrometry. Pharmacokinetic parameters were determined from drug concentration–versus-time data for both cyclophosphamide and 4-OHCP. RESULTS Cyclophosphamide was tolerated well regardless of route of administration. Pharmacokinetic parameters for 4-OHCP were similar after oral, IV, and IP administration. Area under the concentration-time curve for cyclophosphamide was lower after oral administration than after IV or IP administration. CONCLUSIONS AND CLINICAL RELEVANCE Cyclophosphamide can be administered interchangeably to cats as oral, IV, and IP, formulations, which should provide benefits with regard to cost and ease of administration to certain feline patients. (Am J Vet Res 2017;78:862–866)

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“…Whereas 59% of all cats with lymphoma or leukemia were FeLV antigen-positive in one German study from 1980 to 1995, only 20% of the cats were FeLV antigen-positive in the years 1996 to 1999 in the same University Teaching Hospital [41]. In a recent study in the Netherlands, only four of 71 cats with lymphoma were FeLV-positive, although 22 of these cats had mediastinal lymphoma, which previously was strongly associated with FeLV infection [42]. A greater prevalence of lymphoma in older-age cats in now observed.…”

Section: Clinical Signsmentioning

confidence: 99%

Clinical Aspects of Feline Retroviruses: A Review

Hartmann¹

2012

Viruses

274

301

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Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease. FeLV is more pathogenic, and was long considered to be responsible for more clinical syndromes than any other agent in cats. FeLV can cause tumors (mainly lymphoma), bone marrow suppression syndromes (mainly anemia), and lead to secondary infectious diseases caused by suppressive effects of the virus on bone marrow and the immune system. Today, FeLV is less commonly diagnosed than in the previous 20 years; prevalence has been decreasing in most countries. However, FeLV importance may be underestimated as it has been shown that regressively infected cats (that are negative in routinely used FeLV tests) also can develop clinical signs. FIV can cause an acquired immunodeficiency syndrome that increases the risk of opportunistic infections, neurological diseases, and tumors. In most naturally infected cats, however, FIV itself does not cause severe clinical signs, and FIV-infected cats may live many years without any health problems. This article provides a review of clinical syndromes in progressively and regressively FeLV-infected cats as well as in FIV-infected cats.

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Chemotherapy with Cyclophosphamide, Vincristine, and Prednisolone (COP) in Cats with Malignant Lymphoma: New Results with an Old Protocol

Cited by 126 publications

References 16 publications

Prognostic Analyses on Anatomical and Morphological Classification of Feline Lymphoma

Prognostic Analyses on Anatomical and Morphological Classification of Feline Lymphoma

Pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in cats after oral, intravenous, and intraperitoneal administration of cyclophosphamide

Clinical Aspects of Feline Retroviruses: A Review

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